Genetic variation in gut microbe as a key regulator of host social behavior in C. elegans [0.03%]
肠道微生物遗传变异是模式动物社交行为的重要调节因素
Ying Li,Ruijie Bai,Yao Zhu et al.
Ying Li et al.
Gut microbiota have been shown to influence the social behaviors of their hosts, while variations in host genetics can affect the composition of the microbiome. Nonetheless, the degree to which genetic variations in microbial populations im...
Time-restricted feeding protects against septic liver injury by reshaping gut microbiota and metabolite 3-hydroxybutyrate [0.03%]
限时喂养通过重塑肠道菌群和代谢物3-羟基丁酸保护脓毒症肝损伤
Jing-Juan Hu,Fan Deng,Qi-Shun Sun et al.
Jing-Juan Hu et al.
Liver injury is an independent risk factor for multiple organ dysfunction and high mortality in patients with sepsis. However, the pathological mechanisms and therapeutic strategies for sepsis-associated liver injury have not been fully elu...
Bacterial extracellular vesicles in osteoarthritis: a new bridge of the gut-joint axis [0.03%]
肠道-关节轴中的细菌外泌体在骨关节炎中作用的研究
Luyu Niu,Wanzhuo Chen,Zhifeng Yin et al.
Luyu Niu et al.
Osteoarthritis (OA) is a degenerative joint disease primarily characterized by cartilage degeneration. Increasing evidence suggests that there is an interplay between the gut microbiota (GM) and joint health, known as the gut-joint axis. In...
Gut microbiota and epigenetic inheritance: implications for the development of IBD [0.03%]
肠道微生物群和表观遗传继承：对IBD发病机制的影响
Xue Guo,Jianhong Li,Jing Xu et al.
Xue Guo et al.
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is considered significant global health concerns worldwide. Many studies have demonstrated that environmental and dietary factors influence the gut microbio...
Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation [0.03%]
丙酮酸代谢产物乙酰辅酶A积累通过激活STAT3促进核梭杆菌诱导的结肠炎恶化
Zixuan Xiang,Xiangyun Li,Xiaoli Wang et al.
Zixuan Xiang et al.
Fusobacterium nucleatum (F. nucleatum) has emerged as a potential contributor to ulcerative colitis (UC) pathogenesis, although the specific mechanisms remain incompletely understood. This study demonstrates that F. nucleatum promotes colit...
Microbial diversity and fitness in the gut-brain axis: influences on developmental risk for Alzheimer's disease [0.03%]
肠道-大脑轴中的微生物多样性与适应性：对阿尔茨海默病发病风险的影响
Angelo M Jamerlan,Seong Soo A An,John P Hulme
Angelo M Jamerlan
The gut-brain axis (GBA) denotes the dynamic and bidirectional communication system that connects the gastrointestinal tract and the central nervous system (CNS). This review explored this axis, focusing on the role of microbial diversity a...
Protection against experimental necrotizing enterocolitis by fecal filtrate transfer requires an active donor virome [0.03%]
活性供体病毒组要求粪便滤液转移预防实验性坏死性小肠结肠炎
Malene Roed Spiegelhauer,Simone Margaard Offersen,Xiaotian Mao et al.
Malene Roed Spiegelhauer et al.
Necrotizing enterocolitis (NEC) remains a frequent catastrophic disease in preterm infants, and fecal filtrate transfer (FFT) has emerged as a promising prophylactic therapy. This study explored the role of virome viability for the protecti...
Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding [0.03%]
限制性进食介导的肠放射防护作用与肉毒碱抑制肠道铁死亡相关
Yingjuan He,Gaomei Zhao,Xue Ouyang et al.
Yingjuan He et al.
Ionizing radiation-induced intestinal injury (IRIII) is a catastrophic disease lack of sufficient medical countermeasures currently. Regulation of the gut microbiota through dietary adjustments is a potential strategy to mitigate IRIII. Tim...
Helicobacter pylori γ-glutamyltransferase is linked to proteomic adaptions important for colonization [0.03%]
Helicobacter pylori γ-谷氨酰转移酶与定植重要蛋白质组适应有关联
Sonja Fuchs,Michaela K Fiedler,Nicole Heiduk et al.
Sonja Fuchs et al.
Helicobacter pylori γ-glutamyltransferase (gGT) is a virulence factor that promotes bacterial colonization and immune tolerance. Although some studies addressed potential functional mechanisms, the supportive role of gGT for in vivo coloni...
Leveraging strain competition to address antimicrobial resistance with microbiota therapies [0.03%]
利用菌群疗法的竞争应变效应解决抗微生物药物耐药性问题
Danielle Barrios Steed,Dylan Koundakjian,Anthony D Harris et al.
Danielle Barrios Steed et al.
The enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as ...