Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases [0.03%]
肠道微生物群及其相关代谢物：高脂饮食诱导的慢性病的主要参与者
Wei Du,Zhen-Ping Zou,Bang-Ce Ye et al.
Wei Du et al.
Excessive intake of dietary fats is strongly associated with an increased risk of various chronic diseases, such as obesity, diabetes, hepatic metabolic disorders, cardiovascular disease, chronic intestinal inflammation, and certain cancers...
Alexandra Grote,Natav Hendin,Sharon Amit et al.
Alexandra Grote et al.
The ubiquitous bacterial pathogen Salmonella enterica is the causative agent of both enteric fever and gastroenteritis. Despite its significant global health burden, we lack an understanding of its genetic diversity during acute infection, ...
Distinct clusters of bacterial and fungal microbiota in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment, and systemic inflammation [0.03%]
终末期肝硬化中细菌和真菌微生物群的明显聚集与抗生素治疗、肠道屏障功能障碍及系统性炎症相关
Laura Buttler,David A Velázquez-Ramírez,Anja Tiede et al.
Laura Buttler et al.
Decompensated liver cirrhosis (dLC) is associated with intestinal dysbiosis, however, underlying reasons and clinical consequences remain largely unexplored. We investigated bacterial and fungal microbiota, their relation with gut barrier i...
Yao Xu,Zhaoyu Gao,Jiaying Liu et al.
Yao Xu et al.
The pathogenesis of cancer is closely related to the disruption of homeostasis in the human body. The gut microbiome plays crucial roles in maintaining the homeostasis of its host throughout lifespan. In recent years, a large number of stud...
Delivery mode, birth order, and sex impact neonatal microbial colonization [0.03%]
分娩方式、出生顺序和性别影响新生儿微生物定植
Katherine M Kennedy,Andreas Plagemann,Julia Sommer et al.
Katherine M Kennedy et al.
The initial microbial colonization of the infant gut during birth plays a critical role in shaping both immediate and long-term health outcomes. While mode of delivery is a known determinant of this colonization process, the potential impac...
E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult [0.03%]
基因改造的大肠杆菌释放嘌呤碱基促进葡聚糖硫酸钠损伤期间丁酸生成和结肠伤口愈合
J Scott Lee,Daniel J Kao,Corey S Worledge et al.
J Scott Lee et al.
The gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue. Colonic epithelial cells at the microbiota-host interface depe...
Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5 [0.03%]
严重急性胰腺炎后肠道细菌移位的机制研究：Toll样受体5的作用
Cheng Zhang,Shiyin Chen,Zhien Wang et al.
Cheng Zhang et al.
Severe acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients. However, the mechanisms by which SAP disrupted the intestinal barrier and led to bac...
Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode [0.03%]
母乳喂养与婴儿肠道微生物成熟度有关
Nathalia F Naspolini,Paulo A Schüroff,Pedro A R Vanzele et al.
Nathalia F Naspolini et al.
Exclusive breastfeeding (EBF) plays a crucial role in infant gut microbiome assembly and development. However, few studies have investigated the effects of EBF in restoring a perturbed microbiome. In this study, we applied whole metagenomic...
Urease in acetogenic Lachnospiraceae drives urea carbon salvage in SCFA pools [0.03%]
乙酸生成菌Lachnospiraceae的尿素酶驱动SCFA池的尿素碳回收
Isaac J Firth,Marissa A R Sim,Bradley G Fitzgerald et al.
Isaac J Firth et al.
The gut microbiota produces short-chain fatty acids (SCFA) and acidifies the proximal colon which inhibits enteric pathogens. However, for many microbiota constituents, how they themselves resist these stresses is unknown. The anaerobic Lac...
Susan L Hoops,Daphne Moutsoglou,Byron P Vaughn et al.
Susan L Hoops et al.
Reliable engraftment assessment of donor microbial communities and individual strains is an essential component of characterizing the pharmacokinetics of microbiota transplant therapies (MTTs). Recent methods for measuring donor engraftment...