Deep learning-based detection of bacterial swarm motion using a single image [0.03%]
基于深度学习的单幅图像细菌群落运动检测方法
Yuzhu Li,Hao Li,Weijie Chen et al.
Yuzhu Li et al.
Motility is a fundamental characteristic of bacteria. Distinguishing between swarming and swimming, the two principal forms of bacterial movement, holds significant conceptual and clinical relevance. Conventionally, the detection of bacteri...
Faecalibacterium prausnitzii prevents age-related heart failure by suppressing ferroptosis in cardiomyocytes through butyrate-mediated LCN2 regulation [0.03%]
粪球菌通过丁酸介导的LCN2调节抑制心肌细胞铁死亡从而预防年龄相关的心力衰竭
Yun Zhang,Ying Wei,Xuejie Han et al.
Yun Zhang et al.
Aging is a primary driver of the escalating prevalence of heart failure (HF). Age-associated gut microbiota dysbiosis has been implicated in various age-related diseases, yet its role in age-related HF remains largely unexplored. In this st...
Eric Siaw Ntiri,Adam Chun Nin Wong
Eric Siaw Ntiri
The microbiome, especially that present in the gut, has emerged as a key modulator of animal behavior. However, the extent of its influence across species and behavioral repertoires, as well as the underlying mechanisms, remains poorly unde...
The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles [0.03%]
共生肠道微生物群衍生的细胞外囊泡塑造阿尔茨海默病的肠脑轴
Junhua Xie,Lien Van Hoecke,Elien Van Wonterghem et al.
Junhua Xie et al.
Emerging clinical and experimental evidence highlight the involvement of gut microbiota in the onset and progression of neurodegenerative diseases such as Alzheimer's disease (AD) via neuroinflammatory processes along the gut-brain axis. De...
Bacteriophage-driven DNA inversions shape bacterial functionality and long-term co-existence in Bacteroides fragilis [0.03%]
噬菌体驱动的DNA倒位塑造脆弱拟杆菌的功能和长期共存
Shaqed Carasso,Roni Keshet-David,Jia Zhang et al.
Shaqed Carasso et al.
Bacterial genomic DNA inversions, which govern molecular phase-variations, provide the bacteria with functional plasticity and phenotypic diversity. These targeted rearrangements enable bacteria to respond to environmental challenges, such ...
Gut microbiota drives structural variation of exogenous probiotics to enhance colonization [0.03%]
肠道微生物群使外源益生菌发生结构变异以增强定植效果
Shuaiming Jiang,Shi Huang,Zeng Zhang et al.
Shuaiming Jiang et al.
Probiotics encounter colonization resistance from native gut microbiomes, affecting their effectiveness. Genetic engineering of probiotics lacks universal applicability, as gut microbiotas are highly individualized. Here, we employed probio...
Microbial-derived peptidases are altered in celiac disease, non-celiac gluten sensitivity, and functional dyspepsia: a systematic review and re-analysis of the duodenal microbiome [0.03%]
微生物衍生的肽酶在乳糜泻，非乳糜泻性麸质敏感和功能性消化不良中发生变化：系统评价与十二指肠菌群的重新分析
Jennifer C Pryor,Cheenie Nieva,Nicholas J Talley et al.
Jennifer C Pryor et al.
Dietary gluten triggers symptoms in patients with gluten-related disorders (GRDs) including celiac disease (CeD), non-celiac gluten sensitivity (NCGS), and subsets of patients with functional dyspepsia (FD). The gastrointestinal microbiota ...
Engineered bacteria as an orally administered anti-viral treatment and immunization system [0.03%]
工程菌作为口服抗病毒药物和免疫系统
Nitin S Kamble,Shindu Thomas,Tushar Madaan et al.
Nitin S Kamble et al.
The emergence of new viral pathogens necessitates innovative antiviral therapies and vaccines. Traditional approaches, such as monoclonal antibodies and vaccines, are often hindered by resistance, limited effectiveness, and high costs. Here...
Human milk oligosaccharide metabolism and antibiotic resistance in early gut colonizers: insights from bifidobacteria and lactobacilli in the maternal-infant microbiome [0.03%]
人乳低聚糖代谢与早期肠道定植菌抗生素抗性：来自母胎微生物组中双歧杆菌和乳酸菌的启示
Anna Samarra,Simone Renwick,Aleksandr A Arzamasov et al.
Anna Samarra et al.
Breast milk, rich in human milk oligosaccharides (HMOs), supports the early-life colonization of beneficial bacteria such as bifidobacteria and lactobacilli, potentially reducing early-life antibiotic resistance. However, antibiotic treatme...
Fusobacterium mortiferum and its metabolite 5-aminovaleric acid promote the development of colorectal cancer in obese individuals through Wnt/β-catenin pathway by DKK2 [0.03%]
具核梭杆菌及其代谢产物5-氨基戊酸通过DKK2促进肥胖人群结直肠癌的发生发展（Wnt/β-catenin信号通路介导）
Jiaxin Deng,Jiawei Zhang,Mingli Su et al.
Jiaxin Deng et al.
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, with high incidence and mortality rates. An increasing body of research suggests that obesity is a significant risk factor for the development of CRC. Moreover, recent ...