Gut microbiota composition as a candidate risk factor for dimethyl fumarate-induced lymphopenia in multiple sclerosis [0.03%]
肠道微生物群组成作为富马酸二甲酯诱导的多发性硬化淋巴细胞减少症的风险因素候选者
Martin Diebold,Marco Meola,Srinithi Purushothaman et al.
Martin Diebold et al.
Mounting evidence points towards a pivotal role of gut microbiota in multiple sclerosis (MS) pathophysiology. Yet, whether disease-modifying treatments alter microbiota composition and whether microbiota shape treatment response and side-ef...
Observational Study
Gut microbes. 2022 Jan-Dec;14(1):2147055. DOI:10.1080/19490976.2022.2147055 2022
Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206+ macrophagesIL-10 activation [0.03%]
乳酸杆菌johnsonii通过TLR1/2-STAT3介导的CD206+巨噬细胞IL-10激活缓解结肠炎
Ding-Jia-Cheng Jia,Qi-Wen Wang,Ying-Ying Hu et al.
Ding-Jia-Cheng Jia et al.
Imbalance of gut microbiota homeostasis is related to the occurrence of ulcerative colitis (UC), and probiotics are thought to modulate immune microenvironment and repair barrier function. Here, in order to reveal the interaction between UC...
Reproducible changes in the anorexia nervosa gut microbiota following inpatient therapy remain distinct from non-eating disorder controls [0.03%]
住院治疗后厌食症患者胃肠道微生物群的可重复变化仍与无饮食失调对照组不同
Farnaz Fouladi,Emily C Bulik-Sullivan,Elaine M Glenny et al.
Farnaz Fouladi et al.
The composition of the gut microbiota in patients with anorexia nervosa (AN), and the ability of this microbial community to influence the host, remains uncertain. To achieve a broader understanding of the role of the intestinal microbiota ...
Nucleotide binding as an allosteric regulatory mechanism for Akkermansia muciniphila β- N-acetylhexosaminidase Am2136 [0.03%]
Akkermansia muciniphila β-半乳糖苷酶Am2136的核苷酸结合作为变构调节机制
Chang-Cheng Li,Huan Yi,Yan-Mei Wang et al.
Chang-Cheng Li et al.
β-N-acetylhexosaminidases (EC3.2.1.52), which belong to the glycosyl hydrolase family GH20, are important enzymes for oligosaccharides modification. Numerous microbial β-N-acetylhexosaminidases have been investigated for applications in b...
Kidney microbiota dysbiosis contributes to the development of hypertension [0.03%]
肾脏微生物群失调促进高血压的发生发展
Xin-Yu Liu,Jing Li,Yamei Zhang et al.
Xin-Yu Liu et al.
Gut microbiota dysbiosis promotes metabolic syndromes (e.g., hypertension); however, the patterns that drive hypertensive pathology and could be targeted for therapeutic intervention are unclear. We hypothesized that gut microbes might tran...
MlrA, a MerR family regulator in Vibrio cholerae, senses the anaerobic signal in the small intestine of the host to promote bacterial intestinal colonization [0.03%]
MlrA是霍乱弧菌中的一种MerR家族调节因子，可感知宿主小肠中的厌氧信号以促进细菌的肠道定植
Jialin Wu,Yutao Liu,Wendi Li et al.
Jialin Wu et al.
Vibrio cholerae (V. cholerae), one of the most important bacterial pathogens in history, is a gram-negative motile bacterium that causes fatal pandemic disease in humans via oral ingestion of contaminated water or food. This process involve...
Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer [0.03%]
粪便微生物群、蛋白质组和氨基酸谱的整合区分腺瘤和结直肠癌患者
Sofie Bosch,Animesh Acharjee,Mohammed Nabil Quraishi et al.
Sofie Bosch et al.
Background: Screening for colorectal cancer (CRC) reduces its mortality but has limited sensitivity and specificity. Aims We aimed to explore potential biomarker panels for CRC and adenoma detection and to gain insight in...
Multicenter Study
Gut microbes. 2022 Jan-Dec;14(1):2139979. DOI:10.1080/19490976.2022.2139979 2022
Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes [0.03%]
来自肠道Firmicutes的新型酶形成次级异源胆汁酸
Jae Won Lee,Elise S Cowley,Patricia G Wolf et al.
Jae Won Lee et al.
The gut microbiome of vertebrates is capable of numerous biotransformations of bile acids, which are responsible for intestinal lipid digestion and function as key nutrient-signaling molecules. The human liver produces bile acids from chole...
Unique Pakistani gut microbiota highlights population-specific microbiota signatures of type 2 diabetes mellitus [0.03%]
独特的巴基斯坦肠道微生物群强调了2型糖尿病的人群特异性微生物群标志物
Afshan Saleem,Aamer Ikram,Evgenia Dikareva et al.
Afshan Saleem et al.
Biogeographic variations in the gut microbiota are pivotal to understanding the global pattern of host-microbiota interactions in prevalent lifestyle-related diseases. Pakistani adults, having an exceptionally high prevalence of type 2 diab...
Artificial intelligence-based personalized diet: A pilot clinical study for irritable bowel syndrome [0.03%]
基于人工智能的个性化饮食方案在肠易激综合征患者中的临床研究
Tarkan Karakan,Aycan Gundogdu,Hakan Alagözlü et al.
Tarkan Karakan et al.
We enrolled consecutive IBS-M patients (n = 25) according to Rome IV criteria. Fecal samples were obtained from all patients twice (pre-and post-intervention) and high-throughput 16S rRNA sequencing was performed. Six weeks of personalized ...