ILSI Europe perspective review: site-specific microbiota changes during pregnancy associated with biological consequences and clinical outcomes: opportunities for probiotic interventions [0.03%]
国际生命科学学会欧洲分支的综述文章：孕期特定部位菌群的变化与生物学影响及临床结果：利用益生菌进行干预的机会
Eduard Flores Ventura,Jonathan A Lane,Sondra Turjeman et al.
Eduard Flores Ventura et al.
Pregnancy induces notable alterations in the gut, vaginal, and oral microbiota driven by hormonal, immune, metabolic, dietary, and environmental factors. During pregnancy, the gut microbiota is characterized by increased proportions of the ...
Yichang Zhang,Josué L Castro-Mejía,Ling Deng et al.
Yichang Zhang et al.
The factors influencing the establishment of the gut bacterial community in early life are fairly well studied. However, the factors shaping the infant gut virome remain elusive. Interestingly, early life gut virome imbalances have recently...
Advances in the acting mechanism and treatment of gut microbiota in metabolic dysfunction-associated steatotic liver disease [0.03%]
代谢功能异常相关性肝脂肪变性疾病肠菌轴作用机制及治疗进展
Huaying Wu,Jingjing Chen,Shuyuan Guo et al.
Huaying Wu et al.
Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD) is increasing in prevalence worldwide and has become the greatest potential risk for cirrhosis and hepatocellular liver cancer. Currently, the role of gut microbiota in the dev...
Akkermansia muciniphila reverses neuronal atrophy in Negr1 knockout mice with depression-like phenotypes [0.03%]
Akkermansia muciniphila可改善Negr1基因敲除小鼠的抑郁样表型和神经元萎缩现象
Hee-Gon Hwang,Ji-Woo Park,Hyo-Jin Lee et al.
Hee-Gon Hwang et al.
Genetic predispositions can shape the gut microbiome, which in turn modulates host gene expression and impacts host physiology. The complex interplay between host genetics and the gut microbiome likely contributes to the development of neur...
CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation [0.03%]
CD44是产毒性艰难梭菌TcdB的巨噬细胞受体，其赖氨酸158位的琥珀酰化促进炎症反应
Zhuo Chen,Wenzi Zhang,Danni Wang et al.
Zhuo Chen et al.
Toxin B (TcdB) is a critical virulence factor in Clostridioides difficile-associated disease (CDAD), which activates macrophages to promote inflammation and epithelial damage. However, the mechanism by which TcdB targets inflammation-relate...
The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis [0.03%]
溃疡性肠炎相关关节炎患者的肠道黏膜相关菌群中Roseburiaintestinalis相对丰度降低
Madeline Alizadeh,Uni Wong,Bernadette C Siaton et al.
Madeline Alizadeh et al.
The most common extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD), IBD-associated arthritis (IAA), occurs in 25-40% of patients and can be debilitating. In IBD, mucosal and stool microbiota richness is decreased, and ...
Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder [0.03%]
针对肠道菌群的干预措施及其对自闭症谱系障碍患者的胃肠和神经行为症状的潜在影响
Evelyn Takyi,Khemlal Nirmalkar,James Adams et al.
Evelyn Takyi et al.
Autism spectrum disorder (ASD) is a developmental disorder that is characterized by deficits in social communication and restricted, repetitive, and stereotyped behaviors. In addition to neurobehavioral symptoms, children with ASD often hav...
Intestinal and esophageal microbiota in esophageal cancer development and treatment [0.03%]
肠道及食管微生物群与食管癌的发生及治疗的关系研究
Yuta Baba,Kohei Tajima,Kiyoshi Yoshimura
Yuta Baba
Esophageal cancer (EC) is the eleventh most commonly diagnosed cancer, and its prognosis remains poor. Several challenges remain for improving the clinical outcomes of EC, and improving technologies for early detection, diversifying treatme...
Virome drift in ulcerative colitis patients: faecal microbiota transplantation results in minimal phage engraftment dominated by microviruses [0.03%]
溃疡性结肠炎患者的噬菌体组漂变：粪便微生物群移植导致微小病毒为主的噬菌体植入较少
Daan Jansen,Sara Deleu,Clara Caenepeel et al.
Daan Jansen et al.
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients. This underscores the need for ...
Metagenomic analysis reveals distinct patterns of gut microbiota features with diversified functions in C. difficile infection (CDI), asymptomatic carriage and non-CDI diarrhea [0.03%]
元基因组分析揭示了艰难梭菌感染(CDI)、无症状携带和非CDI腹泻患者肠道微生物群特征及其多样化功能的差异模式
Lamei Wang,Xinhua Chen,Nira R Pollock et al.
Lamei Wang et al.
Clostridioides difficile infection (CDI) has been recognized as a leading cause of healthcare-associated infections and a considerable threat to public health globally. Increasing evidence suggests that the gut microbiota plays a key role i...