Relationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes [0.03%]
2型糖尿病患者血清DKK-1与尿微量白蛋白的关系
Ning-Ning Hou,Cheng-Xia Kan,Na Huang et al.
Ning-Ning Hou et al.
Background: Diabetic kidney disease is a microvascular complication of diabetes with complex pathogenesis. Wingless signaling-mediated renal fibrosis is associated with diabetic kidney disease. Dickkopf-1, a negative regu...
Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop [0.03%]
二甲双胍通过TNC/TLR4/NF-κB/miR-155-5p炎症环调节糖尿病肾脏疾病的炎症和纤维化
Yang Zhou,Xiao-Yu Ma,Jin-Yu Han et al.
Yang Zhou et al.
Background: Type 2 diabetes mellitus (T2DM) is significantly increasing worldwide, and the incidence of its complications is also on the rise. One of the main complications of T2DM is diabetic kidney disease (DKD). The gl...
Nihal Ozturk,Serkan Uslu,Semir Ozdemir
Nihal Ozturk
Diabetes mellitus affects the heart through various mechanisms such as microvascular defects, metabolic abnormalities, autonomic dysfunction and incompatible immune response. Furthermore, it can also cause functional and structural changes ...
Exenatide once weekly combined with metformin reduced glycemic variability in type 2 diabetes by using flash glucose monitoring system [0.03%]
利用动态血糖监测系统评价一周一次利西那肽联合二甲双胍治疗减少2型糖尿病患者血糖波动
Yang Li,Min-Min Han,Qiong He et al.
Yang Li et al.
Background: Multiple studies demonstrate that fluctuating blood glucose level produces greater damage compared with sustained hyperglycemia. Flash glucose monitoring system is an effective method in documenting blood gluc...
Diabetic patients with COVID-19 need more attention and better glycemic control [0.03%]
糖尿病患者需要更多关注和更好的血糖控制
Ming Xu,Wen Yang,Tao Huang et al.
Ming Xu et al.
Background: Coronavirus disease 2019 (COVID-19) is a pandemic disease spreading all over the world and has aroused global concerns. The increasing mortality has revealed its severity. It is important to distinguish severe...
Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity [0.03%]
肾上腺素能神经介质激活脂肪细胞葡萄糖转运的作用与肾上腺素受体及单胺氧化酶无关
Jessica Fontaine,Geneviève Tavernier,Nathalie Morin et al.
Jessica Fontaine et al.
Background: Benzylamine and methylamine activate glucose uptake in adipocytes. For tyramine, this effect has even been extended to cardiomyocytes. Aim: ...
Effect of liraglutide on endoplasmic reticulum stress in the renal tissue of type 2 diabetic rats [0.03%]
利拉鲁肽对2型糖尿病大鼠肾脏内质网应激影响的实验研究
Xuan-Ye Zhao,Ting-Ting Yu,Sheng Liu et al.
Xuan-Ye Zhao et al.
Background: Liraglutide is a glucagon-like peptide 1 receptor agonist analog that has been found to have a therapeutic effect in diabetes. In addition to its ability to treat diabetes, liraglutide has beneficial effects o...
Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice [0.03%]
恩格列净缓解db/db糖尿病小鼠的足细胞病并增强肾小球 nephrin 表达
Vadim V Klimontov,Anton I Korbut,Iuliia S Taskaeva et al.
Vadim V Klimontov et al.
Background: Modern guidelines recommend sodium-glucose cotransporter-2 (SGLT2) inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease. However, the mechanisms und...
Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters [0.03%]
生酮饮食及酮体对心血管系统的影响：浓度很重要
Souad Nasser,Varvara Vialichka,Marta Biesiekierska et al.
Souad Nasser et al.
Ketone bodies have emerged as central mediators of metabolic health, and multiple beneficial effects of a ketogenic diet, impacting metabolism, neuronal pathologies and, to a certain extent, tumorigenesis, have been reported both in animal ...
Sensuke Konno
Sensuke Konno
SX-fraction (SXF) is a bioactive glycoprotein with anti-diabetic and hypoglycemic activities that have been documented in several reports. We have reviewed those studies herein and also explored the possible mechanism of its hypoglycemic ac...