Comprehensive Characterization of a Systematic Library of Alkyl and Alicyclic Synthetic Cannabinoids Related to CUMYL-PICA, CUMYL-BUTICA, CUMYL-CBMICA, and CUMYL-PINACA [0.03%]
Comprehensive表征系统库的烷基和脂环族合成大麻素与CUMYL-PICA，CUMYL-BUTICA，CUMYL-CBMICA和CUMYL-PINACA相关的内容特性研究
Liesl K Janssens,Adam Ametovski,Eric Sparkes et al.
Liesl K Janssens et al.
Over 200 synthetic cannabinoid receptor agonists (SCRAs) have been identified as new psychoactive substances. Effective monitoring and characterization of SCRAs are hindered by the rapid pace of structural evolution. Ahead of possible appea...
Aliasghar Sepehri,Themis Lazaridis
Aliasghar Sepehri
Perturbation of cell membranes by amyloid β (Ab) peptide oligomers is one possible mechanism of cytotoxicity in Alzheimer's disease, but the structure of such Ab-membrane complexes is unknown. Here we examine the stability of several putat...
Identification of Triazolopyridines as Selective α5-GABAA Receptor Negative Allosteric Modulators by a Hybridization Approach [0.03%]
通过混合方法识别三氮唑吡啶作为选择性的α5-GABAA受体变构抑制剂
György Szabó,Benedek Imre Károlyi,Ágnes Gyöngyvér Vaskó et al.
György Szabó et al.
The identification and characterization of novel triazolopyridine derivatives with selective α5 subunit-containing GABAA receptor negative allosteric modulator (NAM) activity are disclosed. As a result of in silico screening of our corpora...
Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs [0.03%]
非致幻的5- HT2A受体激动剂Ariadne及其类似物的药理机制
Michael J Cunningham,Hailey A Bock,Inis C Serrano et al.
Michael J Cunningham et al.
Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group ...
In Vitro Diagnosis and Visualization of Cerebral Ischemia/Reperfusion Injury in Rats and Protective Effects of Ferulic Acid by Raman Biospectroscopy and Machine Learning [0.03%]
利用拉曼生物光谱学和机器学习诊断大鼠脑缺血/再灌注损伤及其酸的保护作用研究
Mingying Liu,Ju Mu,Wan Gong et al.
Mingying Liu et al.
Ischemic stroke is a major cause of mortality with complicated pathophysiological mechanisms, and hematoxylin and eosin (HE) staining is a histochemical diagnosis technique heavily relying on subjective observation. In this study, we develo...
Simple, Reliable Protocol for High-Yield Solubilization of Seedless Amyloid-β Monomer [0.03%]
无种子淀粉样蛋白-β单体高产可溶化的简单可靠协议
Alexander I P Taylor,Peter J Davis,Liam D Aubrey et al.
Alexander I P Taylor et al.
Self-assembly of the amyloid-β (Aβ) peptide to form toxic oligomers and fibrils is a key causal event in the onset of Alzheimer's disease, and Aβ is the focus of intense research in neuroscience, biophysics, and structural biology aimed ...
Sequence-Dependent Conformational Properties of PGGG Motif in Tau Repeats: Insights from Molecular Dynamics Simulations of Narrow Pick Filament [0.03%]
Tau重复序列中PGGG基序的序列依赖构象特性：来自窄Pick纤维分子动力学模拟的见解
Allwin Ebenezer Sahayaraj,Renjith Viswanathan,Faina Pinhero et al.
Allwin Ebenezer Sahayaraj et al.
Tauopathies are a class of neurodegenerative diseases correlated with the presence of pathological Tau fibrils as a diagnostic marker. The microtubule-binding repeat region of Tau protein, which includes R1, R2, R3, and R4 repeats, constitu...
Amyotrophic Lateral Sclerosis-Associated Persistent Organic Pollutant cis-Chlordane Causes GABAA-Independent Toxicity to Motor Neurons, Providing Evidence toward an Environmental Component of Sporadic Amyotrophic Lateral Sclerosis [0.03%]
与运动神经元独立毒性有关的肌萎缩侧索硬化相关持久性有机污染物顺式氯丹，为散发性肌萎缩侧索硬化的环境因素提供证据
Daniel Kulick,Emily Moon,R Madison Riffe et al.
Daniel Kulick et al.
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the death of upper and lower motor neurons. While causative genes have been identified, 90% of ALS cases are not inherited and are hypothesized t...
Sensitized 1-Acyl-7-nitroindolines with Enhanced Two-Photon Cross Sections for Release of Neurotransmitters [0.03%]
用于释放神经递质的具有增强二光子截面的敏化1-酰基-7-硝基吲哚啉
Manohar Puppala,Jasmine E Carrothers,Nadeem Asad et al.
Manohar Puppala et al.
Precise photochemical control, using two-photon excitation (2PE), of the timing and location of activation of glutamate is useful for studying the molecular and cellular physiology of the brain. Antenna-based light harvesting strategies rep...
Ghassan Alusi,Elizabeth Berry-Kravis,David Nelson et al.
Ghassan Alusi et al.
Understanding how best to treat aspects of Fragile X syndrome has the potential to improve the quality of life of affected individuals. Such an effective therapy has, as yet, remained elusive. In this article, we ask those researching or af...