Investigation of the Structure of Full-Length Tau Proteins with Coarse-Grained and All-Atom Molecular Dynamics Simulations [0.03%]
粗粒化和全原子分子动力学模拟在全长Tau蛋白结构研究中的应用
Xibing He,Viet Hoang Man,Jie Gao et al.
Xibing He et al.
Tau proteins not only have many important biological functions but also are associated with several neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease (AD). However, it is still a challenge to identify the atomi...
Dulce C Guzmán-Ocampo,Rodrigo Aguayo-Ortiz,José-Luis Velasco-Bolom et al.
Dulce C Guzmán-Ocampo et al.
γ-Secretase (GS) is an intramembrane aspartyl protease that participates in the sequential cleavage of C99 to generate different isoforms of the amyloid-β (Aβ) peptides that are associated with the development of Alzheimer's disease. Due...
Translational Significance of GMF-β Inhibition by Indazole-4-yl-methanol in Enteric Glial Cells for Treating Multiple Sclerosis [0.03%]
吲哚基甲醇通过抑制肠神经胶质细胞中的GMF-β治疗多发性硬化症的转化意义
Sunitha Subhramanian,Ajish Ariyath,Reshma Sabhi et al.
Sunitha Subhramanian et al.
In the emerging context of gut-brain control of multiple sclerosis (MS), developing therapeutics targeting proinflammatory proteins controlling the gut-brain immunomodulation is welcoming. One such immunomodulator is glia maturation factor-...
Plasma Core Alzheimer's Disease Biomarkers Predict Amyloid Deposition Burden by Positron Emission Tomography in Chinese Individuals with Cognitive Decline [0.03%]
血浆核心阿尔茨海默病生物标志物预测中国认知衰退个体正电子发射断层扫描显示的淀粉样蛋白沉积负担
Ming Ni,Ze-Hua Zhu,Feng Gao et al.
Ming Ni et al.
Blood-based biomarkers have been considered as a promising method for the diagnosis of Alzheimer's disease (AD). The reliability and accuracy of plasma core AD biomarkers, including phosphorylated tau (P-tau181), total tau (T-tau), Aβ42, a...
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid [0.03%]
抗精神病药物的宏观环衍生物迅速分离Aβ42单体并防止有毒聚集体和淀粉样蛋白的形成
Sarah R Ball,Julius S P Adamson,Michael A Sullivan et al.
Sarah R Ball et al.
Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required. One possible approach to modulation of the disease outcome is to use small molecules to limit the conversion of m...
β-III Tubulin Levels Determine the Neurotoxicity Induced by Colchicine-Site Binding Agent Indibulin [0.03%]
β-III微管蛋白水平决定结合剂Indibulin诱导的神经毒性
Anuradha Kumari,Shweta S Prassanawar,Dulal Panda
Anuradha Kumari
Indibulin, a microtubule-depolymerizing agent, produces minimal neurotoxicity in animals. It is also less cytotoxic toward differentiated neuronal cells than undifferentiated cells. We found that the levels of β-III tubulin, acetylated tub...
Yue Zhou,Luqiang Sun,Haichuan Wang
Yue Zhou
The prevalence of neonatal hypoxic-ischemic encephalopathy (HIE), a devastating neurological injury, is increasing; thus, effective treatments and preventions are urgently needed. The underlying pathology of HIE remains unclear; recent rese...
Repaglinide Elicits a Neuroprotective Effect in Rotenone-Induced Parkinson's Disease in Rats: Emphasis on Targeting the DREAM-ER Stress BiP/ATF6/CHOP Trajectory and Activation of Mitophagy [0.03%]
雷帕利林在罗滕酮诱导的帕金森病大鼠模型中具有神经保护作用：重点针对DREAM-ER压力BiP / ATF6 / CHOP轨迹和线粒体自噬的激活
Tarek K Motawi,Rawan H Al-Kady,Mahmoud A Senousy et al.
Tarek K Motawi et al.
Repaglinide, a meglitinide insulinotropic antidiabetic, was unraveled as a promising therapeutic agent for Huntington's disease by targeting the neuronal calcium sensor downstream regulatory element antagonist modulator (DREAM). However, it...
Characterization of the Novel P2X7 Receptor Radioligand [3H]JNJ-64413739 in Human Brain Tissue [0.03%]
新型P2X7受体放射配体[3H]JNJ-64413739在人脑组织中的特征分析
Jens D Mikkelsen,Sanjay S Aripaka,Sif Kaad et al.
Jens D Mikkelsen et al.
Radioligands targeting microglia cells have been developed to identify and determine neuroinflammation in the living brain. One recently discovered ligand is JNJ-64413739 that binds selectively to the purinergic receptor P2X7R. The expressi...