Distribution Pattern of Closed and Extended Forms of Glutathione in the Human Brain: MR Spectroscopic Study [0.03%]
人脑中谷胱甘肽闭合型和延伸型分布形式的研究：磁共振波普研究
Pravat K Mandal,Rimil Guha Roy,Avinash Kalyani
Pravat K Mandal
Glutathione (GSH) is a potent antioxidant synthesized de novo in cells and helps to detoxify free radicals in the brain and other organs. In vitro NMR studies from various research groups have reported primarily two sets of chemical shifts ...
Kirsten Elin Smith,Abhisheak Sharma,Oliver Grundmann et al.
Kirsten Elin Smith et al.
Alkaloids from the botanical Mitragyna speciosa (commonly referred to as "kratom") interact with opioid, adrenergic, serotonergic, and other receptors to provide myriad reported effects, including analgesia, energy, improved mood, and relax...
Artificial Neural Networks Coupled with MALDI-TOF MS Serum Fingerprinting To Classify and Diagnose Pathological Pain Subtypes in Preclinical Models [0.03%]
人工神经网络结合MALDI-TOF MS血清指纹分类和诊断预临床模型中的病理疼痛亚型
Meritxell Deulofeu,Eladia M Peña-Méndez,Petr Vaňhara et al.
Meritxell Deulofeu et al.
Pathological pain subtypes can be classified as either neuropathic pain, caused by a somatosensory nervous system lesion or disease, or nociplastic pain, which develops without evidence of somatosensory system damage. Since there is no gold...
Short Peptoid Evolved from the Key Hydrophobic Stretch of Amyloid-β42 Peptide Serves as a Potent Therapeutic Lead of Alzheimer's Disease [0.03%]
源自淀粉样前体蛋白-β42肽关键疏水段的短肽类衍生物作为阿尔茨海默病的有效治疗方案
Rajsekhar Roy,Juhee Khan,Krishnangsu Pradhan et al.
Rajsekhar Roy et al.
Amyloid-β 42(Aβ42), an enzymatically cleaved (1-42 amino acid long) toxic peptide remnant, has long been reported to play the key role in Alzheimer's disease (AD). Aβ42 also plays the key role in the onset of other AD-related factors inc...
Solution Nuclear Magnetic Resonance Structures of ATTTT and ATTTC Pentanucleotide Repeats Associated with SCA37 and FAMEs [0.03%]
与SCA37和FAMEs有关的ATTTT和ATTTC五核苷酸串联重复的溶液核磁共振结构
Jinxia Li,Liqi Wan,Yang Wang et al.
Jinxia Li et al.
Expansions of ATTTT and ATTTC pentanucleotide repeats in the human genome are recently found to be associated with at least seven neurodegenerative diseases, including spinocerebellar ataxia type 37 (SCA37) and familial adult myoclonic epil...
Atrial Natriuretic Peptide Associated with Cardiovascular Diseases Inhibits Amyloid-β Aggregation via Cross-Seeding [0.03%]
与心血管疾病相关的脑利钠肽通过交叉种晶抑制淀粉样蛋白-β的聚集
Yijing Tang,Dong Zhang,Yung Chang et al.
Yijing Tang et al.
Both cardiovascular diseases (CVDs) and Alzheimer's disease (AD) share some common risk factors (e.g., age, obesity, oxidative stress, inflammation, hypertension) that contribute to their overlapping pathogenesis, indicating a "head-to-hear...
Parkin Knockdown Modulates Dopamine Release in the Central Complex, but Not the Mushroom Body Heel, of Aging Drosophila [0.03%]
Parkin敲低可调节老龄果蝇中央复合体中-但不是蘑菇体中的多巴胺释放
Eduard Dumitrescu,Jeffrey M Copeland,B Jill Venton
Eduard Dumitrescu
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons leading to reduced locomotion. Mutations of parkin gene in Drosophila produce the same phenotypes as vertebrate models, but the effect of parkin k...
PolyQ-Expanded Mutant Huntingtin Forms Inclusion Body Following Transient Cold Shock in a Two-Step Aggregation Mechanism [0.03%]
多聚谷氨酰胺延伸的突变型HTT在短暂冷冲击后通过两步聚集机制形成包涵体
Ana Raquel Castro E Costa,Sachin Mysore,Praneet Paruchuri et al.
Ana Raquel Castro E Costa et al.
Age-dependent formation of insoluble protein aggregates is a hallmark of many neurodegenerative diseases. We are interested in the cell chemistry that drives the aggregation of polyQ-expanded mutant Huntingtin (mHtt) protein into insoluble ...
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation [0.03%]
生物仿生脂质模型膜对Aβ42聚集影响的动态图谱
Kevin N Baumann,Greta Šneiderienė,Michele Sanguanini et al.
Kevin N Baumann et al.
The aggregation of the amyloid β (Aβ) peptide is one of the molecular hallmarks of Alzheimer's disease (AD). Although Aβ deposits have mostly been observed extracellularly, various studies have also reported the presence of intracellular...
Evaluation of an Adoptive Cellular Therapy-Based Vaccine in a Transgenic Mouse Model of α-synucleinopathy [0.03%]
在α-突触核蛋白病转基因小鼠模型中对一种采用性细胞治疗疫苗的评价
Winston T Chu,Jesse Hall,Anjela Gurrala et al.
Winston T Chu et al.
Aggregated α-synuclein, a major constituent of Lewy bodies plays a crucial role in the pathogenesis of α-synucleinopathies (SPs) such as Parkinson's disease (PD). PD is affected by the innate and adaptive arms of the immune system, and re...