Joseph A Inger,Elias R Mihan,Jhansi U Kolli et al.
Joseph A Inger et al.
Commonly known as "Quaaludes," methaqualone (1) is a sedative-hypnotic medication, with effects resembling barbiturates and other downers, that exerts its effects through modulation of γ-aminobutyric acid type A receptors (GABAAR). Followi...
Design of Analgesic Trivalent Peptides with Low Withdrawal Symptoms: Probing the Antinociceptive Profile of Novel Linear and Cyclic Peptides as Opioid Pan Ligands [0.03%]
具有较低戒断症状的镇痛三价肽的设计：新型线性和环状肽作为阿片类泛受体配体的抗疼痛特性研究
Azzurra Stefanucci,Paola Minosi,Stefano Pieretti et al.
Azzurra Stefanucci et al.
The discovery of efficacious and safe analgesics with reduced side effects is the foremost challenge in the pain field. In this work, we report the in vitro and in vivo evaluation of linear and cyclic analogues of biphalin with the aim to c...
Evaluation of Copper Chelation Therapy in a Transgenic Rat Model of Cerebral Amyloid Angiopathy [0.03%]
转基因大鼠脑淀粉样血管病铜螯合疗法的评估
Ashwin Ambi,Aleksandra Stanisavljevic,Tiffany W Victor et al.
Ashwin Ambi et al.
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of the amyloid β (Aβ) protein in blood vessels and leads to hemorrhages, strokes, and dementia in elderly individuals. Recent reports have shown elevated copper levels...
Identification of LRRK2 Inhibitors through Computational Drug Repurposing [0.03%]
通过计算药物重新定位识别LRRK2抑制剂
Shuoyan Tan,Ruiqiang Lu,Dahong Yao et al.
Shuoyan Tan et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects more than ten million people worldwide. However, the current PD treatments are still limited and alternative treatment strategies are urgently requir...
Fluoxetine and Curcumin Prevent the Alterations in Locomotor and Exploratory Activities and Social Interaction Elicited by Immunoinflammatory Activation in Zebrafish: Involvement of BDNF and Proinflammatory Cytokines [0.03%]
氟西汀和姜黄素预防免疫炎症激活在斑马鱼中引起的运动、探究活动和社会交往的改变：BDNF和促炎细胞因子的作用
Fernanda Petry,Amanda R Oltramari,Ketelin Z Kuhn et al.
Fernanda Petry et al.
The increase in proinflammatory cytokine expression causes behavioral changes consistent with sickness behavior, and this led to the suggestion that depression might be a psychoneuroimmunological phenomenon. Here, we evaluated the effects o...
Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin [0.03%]
氯胺酮和裸盖菇素引起即刻早期基因表达的脑区共享与区别
Pasha A Davoudian,Ling-Xiao Shao,Alex C Kwan
Pasha A Davoudian
Psilocybin is a psychedelic with therapeutic potential. While there is growing evidence that psilocybin exerts its beneficial effects through enhancing neural plasticity, the exact brain regions involved are not completely understood. Deter...
5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines [0.03%]
血清素2A受体介导致幻剂色胺的治疗行为效果
Lindsay P Cameron,Seona D Patel,Maxemiliano V Vargas et al.
Lindsay P Cameron et al.
Psychedelic compounds have displayed antidepressant potential in both humans and rodents. Despite their promise, psychedelics can induce undesired effects that pose safety concerns and limit their clinical scalability. The rational developm...
Evaluation of [18F]PF-06455943 as a Potential LRRK2 PET Imaging Agent in the Brain of Nonhuman Primates [0.03%]
[18F]PF-06455943作为非人灵长类动物脑中LRRK2示踪剂的潜力评估
Chi-Hyeon Yoo,Zhen Chen,Nisha Rani et al.
Chi-Hyeon Yoo et al.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the common causes of inherited Parkinson's disease (PD) and emerged as a causative PD gene. Particularly, LRRK2-Gly2019Ser mutation was reported to alter the early phase of neur...
New Insights into the Structural and Binding Properties on Aβ Mature Fibrils Due to Histidine Protonation Behaviors [0.03%]
组氨酸质子化的特性对成熟Aβ纤维结构和结合特性的新见解
Hu Shi,Yue Sun,Zeshuai Yao et al.
Hu Shi et al.
Histidine tautomeric behaviors have been considered origin factors for controlling the structure and aggregation properties of misfolding peptides. Except for tautomeric behaviors, histidine protonation behaviors definitely have the same ca...
Angiopep-2, an MRI Biomarker, Dynamically Monitors Amyloid Deposition in Early Alzheimer's Disease [0.03%]
Angiopep-2作为一种MRI生物标志物动态监测早期阿尔茨海默病中的淀粉样蛋白沉积
Liang Xu,Lingfeng Lai,Yaqi Wen et al.
Liang Xu et al.
The reliable and dynamic detection of amyloid β-protein (Aβ) deposition using imaging technology is necessary for preclinical Alzheimer's disease (AD), which may significantly improve prognosis. The present study aimed to evaluate the fea...