Effect of P-Glycoprotein on the Blood-Brain Barrier Transport of the Major Active Constituents of Salvia miltiorrhiza Based on the MDCK-MDR1 Cell Model [0.03%]
基于MDCK-MDR1细胞模型的P-糖蛋白对丹参主要活性成分血脑屏障转运的影响
Jiahao Fang,Yuzhen He,Yuhong Cao et al.
Jiahao Fang et al.
Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a traditional Chinese medicine that has been widely used in the treatment of various central nervous system (CNS) diseases. However, the mechanism of active components of S. miltiorrhiza crossi...
Structural and Molecular Determinants for Isoform Bias at Human Histamine H3 Receptor Isoforms [0.03%]
人组胺H3受体异构体的异构体偏向的结构和分子决定因素
Sabrina N Rahman,Daniel A McNaught-Flores,Yara Huppelschoten et al.
Sabrina N Rahman et al.
The human histamine H3 receptor (hH3R) is predominantly expressed in the CNS, where it regulates the synthesis and release of histamine and other neurotransmitters. Due to its neuromodulatory role, the hH3R has been associated with various ...
Exploring the Epigenetic Regulated Modulation of Fibroblast Growth Factor 21 Involvement in High-Fat Diet Associated Parkinson's Disease in Rats [0.03%]
探讨表观遗传调控的纤维生长因子21在高脂饮食相关的大鼠帕金森病中的作用机制
Violina Kakoty,Sarathlal Kc,Chih-Hao Yang et al.
Violina Kakoty et al.
Imbalance in brain glucose metabolism and epigenetic modulation during the disease course of insulin resistance (IR) associated with Parkinson's disease (PD) risk remains a prime concern. Fibroblast growth factor 21 (FGF21), the metabolic h...
Molecular Modeling Study of a Receptor-Orthosteric Ligand-Allosteric Modulator Signaling Complex [0.03%]
受体-正构配体-变构调节剂信号复合物的分子模型研究
Chen Jiang,Xibing He,Yuanqiang Wang et al.
Chen Jiang et al.
Allosteric modulators (AMs) are considered as a perpetual hotspot in research for their higher selectivity and various effects on orthosteric ligands (OL). They are classified in terms of their functionalities as positive, negative, or sile...
Effects of Aluminum Oxide Nanoparticles in the Cerebrum, Hippocampus, and Cerebellum of Male Wistar Rats and Potential Ameliorative Role of Melatonin [0.03%]
氧化铝纳米粒子对雄性Wistar大鼠大脑、海马和小脑的影响以及褪黑激素潜在的改善作用
Nermeen G Abdelhameed,Yasmine H Ahmed,Noha A E Yasin et al.
Nermeen G Abdelhameed et al.
Aluminum oxide nanoparticles (Al2O3 NPs) have been widely used in vaccine manufacture, food additives, human care products, and cosmetics. However, they also have adverse effects on different organs, including the liver, kidneys, and testes...
Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study [0.03%]
Tau蛋白R2重复区的磷酸化作用会破坏其与微管的结合：一项分子动力学模拟研究
Viet Hoang Man,Xibing He,Jie Gao et al.
Viet Hoang Man et al.
Phosphorylation, the most popular post-translational modification of tau protein, plays an important role in regulating tau physiological functions. However, aberrant phosphorylation attenuates the binding affinity of tau to a microtubule (...
Immunohistochemical Localization of MD2, a Co-Receptor of TLR4, in the Adult Mouse Brain [0.03%]
TLR4的共受体MD2在成年小鼠脑中的免疫组织化学定位研究
Zhen Li,Aiwen Chen,Hanxi Wan et al.
Zhen Li et al.
Myeloid differentiation factor 2 (MD2) is a co-receptor of a classical proinflammatory protein TLR4 whose activation leads to neuroinflammation. It is widely accepted that TLR4 is expressed on the cell surface of microglia and astrocytes, a...
Lysine Acetylation Changes the Mechanism of Aβ25-35 Peptide Binding and Dimerization in the DMPC Bilayer [0.03%]
赖氨酸乙酰化改变了Aβ25-35肽在DMPC双层中的结合和二聚化机制
Elias Khayat,Bryan M Delfing,Xavier Laracuente et al.
Elias Khayat et al.
The impact of Lys28 acetylation on Alzheimer's Aβ peptide binding to the lipid bilayer has not been previously studied, either experimentally or computationally. To probe this common post-translational modification, we performed all-atom r...
M1/M4-Preferring Muscarinic Cholinergic Receptor Agonist Xanomeline Reverses Wake and Arousal Deficits in Nonpathologically Aged Mice [0.03%]
M1/M4偏好型毒蕈碱胆碱能受体激动剂Xanomeline逆转非病理性老化小鼠的觉醒和唤醒缺陷
Jason K Russell,Shalonda M Ingram,Laura B Teal et al.
Jason K Russell et al.
Degeneration of the cholinergic basal forebrain is implicated in the development of cognitive deficits and sleep/wake architecture disturbances in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Indirect-acting muscarinic chol...
Xinyi Gao,Zhifei Wang,Lixia Du
Xinyi Gao
Glial cells, which are the non-neuronal cells of the nervous system, play essential roles in brain development, homeostasis, and diseases. Glial cells have attracted attention because of their active involvement in many neurological disorde...