Comprehensive Review on Potential Signaling Pathways Involving the Transfer of α-Synuclein from the Gut to the Brain That Leads to Parkinson's Disease [0.03%]
涉及α-突触核蛋白从肠道转移到大脑的潜在信号通路的全面综述——导致帕金森病的相关机制研究
Shobha Kumari,Rajeev Taliyan,Sunil Kumar Dubey
Shobha Kumari
Parkinson's disease is the second most prevalent neurological disease after Alzheimer's. Primarily, old age males are more affected than females. The aggregates of oligomeric forms of α-synuclein cause the loss of dopaminergic neurons in t...
Exploring the Role of Neurotransmitters in Multiple Sclerosis: An Expanded Review [0.03%]
多发性硬化症中神经递质的作用：综述及展望
Enes Akyuz,Betul Rana Celik,Feyza Sule Aslan et al.
Enes Akyuz et al.
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS). Although emerging evidence has shown that changes in neurotransmitter levels in the synaptic gap may contribute to the path...
Diurnal Fluctuations of Orexin-A and -B in Cynomolgus Monkey Cerebrospinal Fluid Determined by a Novel Analytical Method Using Antiadsorptive Additive Treatment Followed by Nanoflow Liquid Chromatography-High-Resolution Mass Spectrometry [0.03%]
应用新型纳流液相色谱高分辨质谱分析方法测定食蟹猴脑脊液中食欲素A和B的昼夜波动规律
Naohiro Narita,Ryuji Yamada,Masaaki Kakehi et al.
Naohiro Narita et al.
Orexin-A (OXA) and -B (OXB) are involved in the regulation of multiple physiological functions including the sleep-wake states; therefore, it is critical to monitor their levels under various conditions. Unfortunately, the widely used radio...
Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release [0.03%]
光解封闭和释放技术在脑内神经肽递送研究中的作用
Hejian Xiong,Blake A Wilson,Paul A Slesinger et al.
Hejian Xiong et al.
Neuropeptides are abundant and essential signaling molecules in the nervous system involved in modulating neural circuits and behavior. Neuropeptides are generally released extrasynaptically and signal via volume transmission through G-prot...
Gallic Acid Improves Comorbid Chronic Pain and Depression Behaviors by Inhibiting P2X7 Receptor-Mediated Ferroptosis in the Spinal Cord of Rats [0.03%]
没食子酸通过抑制脊髓P2X7受体介导的铁死亡改善大鼠慢性疼痛合并抑郁行为
Runan Yang,Liran Shi,Han Si et al.
Runan Yang et al.
Ferroptosis is an inflammatory programmed cell death process that is dependent on iron deposition and lipid peroxidation. The P2X7 receptor not only is involved in the pain process but also is closely related to the onset of depression. Gal...
Prenatal Sevoflurane Exposure Impairs the Learning and Memory of Rat Offspring via HMGB1-Induced NLRP3/ASC Inflammasome Activation [0.03%]
七氟醚孕期暴露通过诱导HMGB1-NLRP3/ASC炎症小体激活损伤子代大鼠学习记忆能力
Yangyang Shan,Panmiao Liu,Yanbo Zhou et al.
Yangyang Shan et al.
The neurotoxic effects of sevoflurane anesthesia on the immature nervous system have aroused public concern, but the specific effects and mechanism remain poorly understood. Pyroptosis caused by the activation of the NLRP3 inflammasome is p...
Sulfated Hyperbranched and Linear Polyglycerols Modulate HMGB1 and Morphological Plasticity in Neural Cells [0.03%]
硫酸化超支化和线性聚甘油醇调节神经细胞中的HMGB1和形态可塑性
Dusica Maysinger,Issan Zhang,Pei You Wu et al.
Dusica Maysinger et al.
The objective of this study was to establish if polyglycerols with sulfate or sialic acid functional groups interact with high mobility group box 1 (HMGB1), and if so, which polyglycerol could prevent loss of morphological plasticity in exc...
Thrsp Gene and the ADHD Predominantly Inattentive Presentation [0.03%]
THRSP基因与注意缺陷多动障碍以注意力不足为主的症状组合
Raly James Perez Custodio,Mikyung Kim,Young-Chul Chung et al.
Raly James Perez Custodio et al.
There are three presentations of attention-deficit/hyperactivity disorder (ADHD): the predominantly inattention (ADHD-PI), predominantly hyperactive-impulsive (ADHD-HI), and combined (ADHD-C) presentations of ADHD. These may represent disti...
Cardiolipin-Mediated Alleviation of Mitochondrial Dysfunction Is a Neuroprotective Effect of Statin in Animal Model of Ischemic Stroke [0.03%]
他汀类药物通过线粒体靶点 cardiolipin 缓解缺血性脑卒中神经元损伤的作用及机制研究
Deepaneeta Sarmah,Abhishek Sarkar,Aishika Datta et al.
Deepaneeta Sarmah et al.
In clinical settings, the benefit of statin for stroke is debatable as regular statin users may suffer from myalgia, statin-associated myopathy (SAM), and rarely rhabdomyolysis. Studies suggest that patients on statin therapy show lesser vu...
Differential Effects of Nicotine, Alcohol, and Coexposure on Neuroimmune-Related Protein and Gene Expression in Corticolimbic Brain Regions of Rats [0.03%]
尼古丁、酒精及其联合作用对大鼠皮层边缘脑区神经免疫相关蛋白和基因表达的差异性影响
Christie A Randall,Dongxiao Sun,Patrick A Randall
Christie A Randall
Nicotine and alcohol co-use is extremely common and their use constitutes two of the most common causes of preventable death, yet the underlying biological mechanisms are largely understudied. Activation of neuroimmune toll-like receptors (...