Mechanistic Insight into the Inhibition of Choline Acetyltransferase by Proton Pump Inhibitors [0.03%]
质子泵抑制剂抑制胆碱乙酰转移酶的机理研究
Anurag T K Baidya,Bhanuranjan Das,Bharti Devi et al.
Anurag T K Baidya et al.
Various pharmacoepidemiological investigational studies have indicated that Proton Pump Inhibitors (PPIs) may increase the likelihood of developing Alzheimer's disease (AD) and non-AD related dementias. Previously, we have reported the inhi...
Compensatory Contextual Fear Memory Pathways Develop in the Infralimbic Cortex within 3 Days after the First Test in the Absence of the Dorsal Hippocampus [0.03%]
背侧海马缺失后，损毁前扣带回的动物在首次测试后的三天内会通过腹侧海马和杏仁核发展补偿性上下文恐惧记忆通路
Deepika Kant,Sushil K Jha
Deepika Kant
The dorsal hippocampus (DH) is primarily involved in the formation of contextual fear-conditioned (CxFC) memory. However, CxFC memory can be formed even in the absence of the DH. In addition to the DH, the infralimbic cortex (IL), a sub-reg...
SARS-CoV-2 Spike Protein Downregulates Cell Surface α7nAChR through a Helical Motif in the Spike Neck [0.03%]
新冠病毒刺突蛋白通过刺突杆部的螺旋结构下调细胞表面α7nAchR表达
Tommy S Tillman,Qiang Chen,Vasyl Bondarenko et al.
Tommy S Tillman et al.
A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs neuronal and immune systems. The SARS-CoV-2 spike protein (S12) facilitates virus cell entry during COVID-19 infection and can also independently disrupt...
Istvan Horvath,Pernilla Wittung-Stafshede
Istvan Horvath
Amyloid fibers of the protein α-synuclein, found in Lewy body deposits, are hallmarks of Parkinson's disease. We here show that α-synuclein amyloids catalyze biologically relevant chemical reactions in vitro. Amyloid fibers, but not monom...
Do 2-(Benzoyl)piperidines Represent a Novel Class of hDAT Reuptake Inhibitors? [0.03%]
2-(苯甲酰基)哌啶类化合物是人源多巴胺转运体的新型抑制剂吗？
Charles B Jones,Jose M Eltit,Małgorzata Dukat
Charles B Jones
2-(Benzoyl)piperidines (analogues of 1a), structural hybrids of the clinically employed ADHD medication methylphenidate (2) and the abused synthetic cathinone pentedrone (3), have been previously reported to act as novel and selective reupt...
Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences [0.03%]
甘丙肽神经肽研究概览：从化学到神经科学中的药理应用
Sara C Silva-Reis,Ivo E Sampaio-Dias,Vera M Costa et al.
Sara C Silva-Reis et al.
Neurodegenerative diseases of the central nervous system (CNS) pose a serious health concern worldwide, with a particular incidence in developed countries as a result of life expectancy increase and the absence of restorative treatments. Pr...
Structure-Activity Relationship of N-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice [0.03%]
N-乙基-六氢酮类似物的构效关系：α碳侧链长度在作用机制，细胞毒性和小鼠行为效应中的作用
Núria Nadal-Gratacós,Edwin Ríos-Rodríguez,David Pubill et al.
Núria Nadal-Gratacós et al.
Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased dramatically in the past decades. N-Ethyl substituted cathinones have been proven to potently inhibit dopamine (DA) uptake and induce psychostimulant an...
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation [0.03%]
维生素A和维生素E代谢物的组合可抵抗淀粉样蛋白-β聚集以提高细胞耐受力
Priyanka Joshi,Sean Chia,Xiaoting Yang et al.
Priyanka Joshi et al.
Alzheimer's disease is characterized by the presence in the brain of amyloid plaques formed by the aberrant deposition of the amyloid-β peptide (Aβ). Since many vitamins are dysregulated in this disease, we explored whether these molecule...
Vanillin Benzothiazole Derivative Reduces Cellular Reactive Oxygen Species and Detects Amyloid Fibrillar Aggregates in Alzheimer's Disease Brain [0.03%]
香草醛苯并噻唑衍生物可降低细胞内活性氧并检测阿尔茨海默病大脑中的淀粉样纤维聚集物
Prabir Kumar Gharai,Juhee Khan,Rathnam Mallesh et al.
Prabir Kumar Gharai et al.
The misfolding of amyloid beta (Aβ) peptides into Aβ fibrillary aggregates is a major hallmark of Alzheimer's disease (AD), which responsible for the excess production of hydrogen peroxide (H2O2), a prominent reactive oxygen species (ROS)...
Positron Emission Tomography for the Discovery of New Drugs in Psychiatry [0.03%]
精神病学新药发现的正电子发射断层扫描技术
Luc Zimmer
Luc Zimmer
The arsenal of drugs for psychiatry has been difficult to renew for several decades. Many failures in therapeutic trials can be explained by poorly evaluated pharmacological properties, in terms of brain passage, target binding, and functio...