Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model [0.03%]
一种新型选择性GluN2B-NMDA受体阴性变构调节剂具有镇痛作用并可增强氯诺昔康的小鼠舔缩试验中的镇痛作用
Lynnea D Harris,Michael C Regan,Scott J Myers et al.
Lynnea D Harris et al.
Many cases of accidental death associated with drug overdose are due to chronic opioid use, tolerance, and addiction. Analgesic tolerance is characterized by a decreased response to the analgesic effects of opioids, requiring increasingly h...
Role of the Peli1-RIPK1 Signaling Axis in Methamphetamine-Induced Neuroinflammation [0.03%]
Peli1-RIPK1信号轴在甲基苯丙胺诱导的神经炎症中的作用
Weixiao Xu,Tingyu Yang,Xinyu Lou et al.
Weixiao Xu et al.
Severe neurological inflammation is one of the main symptoms of methamphetamine (meth)-induced brain injury. Studies have demonstrated that meth exposure facilitates neuroinflammation via Pellino E3 ubiquitin protein ligase 1 (Peli1)-mediat...
An S-Shaped Aβ42 Cross-β Hexamer Embedded into a Lipid Bilayer Reveals Membrane Disruption and Permeability [0.03%]
基于脂质双层的淀粉样蛋白β肽Aβ42交叉β折叠六聚体揭示了对膜稳定性和渗透性的影响
Phuong H Nguyen,Philippe Derreumaux
Phuong H Nguyen
The interactions of amyloid oligomers with membranes are known to contribute to cellular toxicity. Numerous in vitro experimental studies reported on the insertion of oligomers of different sizes that can induce cell membrane disruption, ex...
UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death [0.03%]
UBA52通过调节VDAC1介导的线粒体功能障碍及多巴胺能神经元死亡参与发病进程
Shubhangini Tiwari,Abhishek Singh,Parul Gupta et al.
Shubhangini Tiwari et al.
Mitochondrial homeostasis regulates energy metabolism, calcium buffering, cell function, and apoptosis. The present study has been conducted to investigate the implications of the ubiquitin-encoding gene UBA52 in mitochondrial physiology. T...
Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (Danio rerio) [0.03%]
用于斑马鱼的 psychedelics 和其他药物滥用的发育神经毒性筛查
Robert J Tombari,Paige C Mundy,Kelly M Morales et al.
Robert J Tombari et al.
In recent years, psychedelics have garnered significant interest as therapeutic agents for treating diverse neuropsychiatric disorders. However, the potential for these compounds to produce developmental neurotoxicity has not been rigorousl...
Neuroprotective Effect of Propolis Polyphenol-Based Nanosheets in Cellular and Animal Models of Rotenone-Induced Parkinson's Disease [0.03%]
罗塔若宁诱导的帕金森病细胞和动物模型中的蜂胶多酚基纳米片神经保护作用
Fatemeh Mamashli,Ali Akbar Meratan,Atiyeh Ghasemi et al.
Fatemeh Mamashli et al.
Considering the central role of oxidative stress in the onset and progress of Parkinson's diseases (PD), search for compounds with antioxidant properties has attracted a growing body of attention. Here, we compare the neuroprotective effect...
Molecular Mechanism in the Disruption of Chronic Traumatic Encephalopathy-Related R3-R4 Tau Protofibril by Quercetin and Gallic Acid: Similarities and Differences [0.03%]
槲皮素和没食子酸干扰慢性创伤性脑病相关Tau蛋白R3-R4原纤维化的分子机制：同异比较研究
Jiaxing Tang,Yu Zou,Yehong Gong et al.
Jiaxing Tang et al.
Chronic traumatic encephalopathy (CTE) is a unique progressive neurodegenerative tauopathy pathologically related to the aggregation of the tau protein to neurofibrillary tangles. Disrupting tau oligomers (protofibril) is a promising strate...
D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models [0.03%]
化合物D-685逆转帕金森病动物模型的运动障碍并减少人α-突触核蛋白聚集
Aloke K Dutta,Christopher Armstrong,Dan Luo et al.
Aloke K Dutta et al.
Aggregation of misfolded α-synuclein (α-syn) protein in the periphery and central nervous system (CNS) gives rise to a group of disorders, which are labeled collectively as synucleinopathies. These clinically distinct disorders are known ...
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques [0.03%]
一种用于有效体内成像淀粉样蛋白-β斑块的香豆素类荧光探针的设计
Yangyang Cao,Xiaohui Liu,Jingjing Zhang et al.
Yangyang Cao et al.
Amyloid-β (Aβ) is the core constituent protein of senile plaques, which is one of the key pathological hallmarks of Alzheimer's disease (AD). Here we describe the design, synthesis, and evaluation of coumarin-derived small molecule fluoro...
pH Effects Can Dominate Chemical Shift Perturbations in 1H,15N-HSQC NMR Spectroscopy for Studies of Small Molecule/α-Synuclein Interactions [0.03%]
在研究小分子与α-突触核蛋白相互作用的二维氮-15磁共振实验中，PH变化对化学位移的影响不容忽视
Anil K Pandey,Caroline R Buchholz,Noah Nathan Kochen et al.
Anil K Pandey et al.
1H,15N-Heteronuclear Single Quantum Coherence (HSQC) NMR is a powerful technique that has been employed to characterize small-molecule interactions with intrinsically disordered monomeric α-Synuclein (aSyn). We report how solution pH can i...