Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors [0.03%]
GSK3α结构的阐明为设计新型同源选择性抑制剂提供依据
Brenda Amaral,Andrew Capacci,Trip Anderson et al.
Brenda Amaral et al.
Glycogen synthase kinase 3 (GSK3) remains a therapeutic target of interest for diverse clinical indications. However, one hurdle in the development of small molecule GSK3 inhibitors has been safety concerns related to pan-inhibition of both...
1H NMR Metabolomics and Lipidomics To Monitor Positive Responses in Children with Autism Spectrum Disorder Following a Guided Parental Intervention: A Pilot Study [0.03%]
一项针对自闭症光谱障碍儿童的家长干预效果监测的核磁代谢组学及脂质组学研究：初步研究报告
Banny Silva Barbosa Correia,João Guilherme de Moraes Pontes,João Victor Silva Nani et al.
Banny Silva Barbosa Correia et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is characterized by patients displaying at least two out of the classical symptoms, such as impaired social communication, impaired interactions, and restricted r...
Bicuculline and Bumetanide Attenuate Sevoflurane-Induced Impairment of Myelination and Cognition in Young Mice [0.03%]
士的宁和丁氨苯蝶啶能减轻吸入异氟醚对幼年小鼠髓鞘形成及认知功能的影响
Ningning Fu,Yangyang Wang,Ruilou Zhu et al.
Ningning Fu et al.
Sevoflurane (Sevo) is one of the most commonly used general anesthetics for infants and young children. We investigated whether Sevo impairs neurological functions, myelination, and cognition via the γ-aminobutyric acid A receptor (GABAAR)...
Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model [0.03%]
聚茋酸aine通过海马树突棘重塑缓解慢性应激所致的小鼠抑郁和焦虑样行为
Jianping Wang,Yujiao Men,Zeyu Wang
Jianping Wang
We aimed to investigate whether polydatin could suppress stress-induced depression- and anxiety-like behaviors in a mouse model. Mice were divided into the control group, chronic unpredictable mild stress (CUMS) exposure group, and CUMS mic...
Cell-Surface Targeting of Fluorophores in Drosophila for Rapid Neuroanatomy Visualization [0.03%]
果蝇细胞表面荧光素靶向技术在快速神经解剖学可视化中的应用
Molly J Kirk,Arya Gold,Ashvin Ravi et al.
Molly J Kirk et al.
Visualizing neuronal anatomy often requires labor-intensive immunohistochemistry on fixed and dissected brains. To facilitate rapid anatomical staining in live brains, we used genetically targeted membrane tethers that covalently link fluor...
Alleviation of Cocaine Withdrawal and Pertinent Interactions between Salvinorin-Based Antagonists and Kappa Opioid Receptor [0.03%]
萨拉瓦宁素衍生物通过作用于κ阿片受体戒毒机制研究
Nicholas S Akins,Mohammed F Salahuddin,Pankaj Pandey et al.
Nicholas S Akins et al.
The kappa opioid receptor (KOR) is involved in the regulation of both the reward and mood processes. Recent reports find that the use of drugs of abuse increases the production of dynorphin and the overall activation of KOR. Long-acting KOR...
Synthesis and In Vitro and In Vivo Evaluation of 18F-Labeled Positron Emission Tomography Tracers for Imaging Aβ Plaques [0.03%]
用于成像Aβ斑块的正电子发射断层显像（PET）示踪剂18F标记化合物的合成及其体外和体内评价
Wei Zheng,Yong Huang,Hualong Chen et al.
Wei Zheng et al.
Accurate quantification of amyloid beta (Aβ) plaques is an important indicator for Alzheimer's disease diagnosis and treatment. For this purpose, new highly sensitive Aβ tracers were designed by regulating the position and number of nitro...
In Vivo and 3D Imaging Technique(s) for Spatiotemporal Mapping of Pathological Events in Experimental Model(s) of Spinal Cord Injury [0.03%]
脊髓损伤实验模型中病理事件时空映射的活体和三维成像技术
Divya Goyal,Hemant Kumar
Divya Goyal
Endothelial damage, astrogliosis, microgliosis, and neuronal degeneration are the most common events after spinal cord injury (SCI). Studies highlighted that studying the spatiotemporal profile of these events might provide a deeper underst...
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand [0.03%]
一种减少氟化哈洛peridol的二氟类似物作为σ-1受体配体的合成与药理学表征
Run-Duo Gao,Michelle Taylor,Tamara McInnis et al.
Run-Duo Gao et al.
Reduced haloperidol (1) was previously reported to act as a potent sigma-1 receptor (S1R) ligand with substantially lower affinity to the dopamine D2 receptor (D2R) compared to haloperidol. It was also found to facilitate brain-derived neur...
Transthyretin Binding Mode Dichotomy of Fluorescent trans-Stilbene Ligands [0.03%]
荧光反式茋配体结合 transthyretin 的双重模式
Afshan Begum,Jun Zhang,Dean Derbyshire et al.
Afshan Begum et al.
The orientations of ligands bound to the transthyretin (TTR) thyroxine (T4) binding site are difficult to predict. Conflicting binding modes of resveratrol have been reported. We previously reported two resveratrol based trans-stilbene fluo...