Pathogenic TRIM74 Mutation Disrupts Protein Homeostasis and Triggers Proteotoxic Neurodegeneration via Structural Destabilization [0.03%]
致病性TRIM74基因突变通过结构不稳定性破坏蛋白稳态并引发蛋白毒性神经退行性疾病
S Rehan Ahmad,Abdullah M AlShahrani,Anupriya Kumari
S Rehan Ahmad
Ubiquitin ligases play a critical role in maintaining proteostasis, synaptic function, and neuronal survival, and their dysfunction is increasingly implicated in neurodevelopmental disorders with neurodegenerative features. In this study, w...
Exploring Esketamine's Therapeutic Role for Perinatal Depression via TASK-1 Tandem Pore Potassium Channels [0.03%]
通过TASK-1串联孔钾通道探讨右美沙芬在围产期抑郁的治疗作用
Lin Zhu,Ji Chen,Yuan Liu et al.
Lin Zhu et al.
This research focuses on the promising use of esketamine in perinatal depression, a widespread disorder impacting postpartum women's mental health. Despite esketamine's known rapid antidepressant effects, its precise mechanisms are not full...
Enhanced Positron Emission Tomography Imaging of β-Amyloid through Focused Ultrasound-Mediated Gallium-68 Radiotracer Delivery across the Blood-Brain Barrier [0.03%]
聚焦超声介导血脑屏障通透结合镓68放射示踪剂的阿尔茨海默病β淀粉样蛋白正电子发射断层扫描成像技术
Wenjing Li,Xiaochuan Zha,Xiaoyu Zhang et al.
Wenjing Li et al.
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is an innovative approach for enhancing the delivery of central nervous system drugs. 68Ga radiotracers are advantageous for imaging due to their ideal half-life and imagin...
Identification of Novel Triazole-Pyrazole Conjugates as Potential Anticonvulsant Agents: Synthesis and Biological Evaluations [0.03%]
新型三唑-吡唑共轭物作为潜在抗惊厥剂的鉴定：合成与生物评价
Wagdy M Eldehna,Mahmoud Abdelrahman Alkabbani,Zainab M Elsayed et al.
Wagdy M Eldehna et al.
Since epilepsy is still a complex neurological condition, better and more efficient treatment methods are needed. This study used PTZ- and PIL-induced seizure models to evaluate the anticonvulsant activity of some recently synthesized compo...
Decoding the Relationship between Alzheimer's Disease and Type-2 Diabetes via the Protein Aggregation Prism [0.03%]
从蛋白质聚集的角度解析阿尔茨海默病与二型糖尿病的关系
Vaishnavi Tammara,Atanu Das
Vaishnavi Tammara
Alzheimer's disease (AD) and type-2 diabetes (T2D) are two fatal human diseases and have been linked to the aberrant aggregation of two distinct peptides, amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP), respectively. These two...
The Synergistic Potential of Rationally Designed Phenol-Triazole Derivatives to Attenuate Aβ/Cu2+-Aβ Aggregation and Reactive Oxygen Species [0.03%]
合理设计酚基三唑衍生物协同抑制Aβ/Cu₂⁺-Aβ聚集和活性氧的潜力
Gagandeep Kaur,Opinder Kaur Mankoo,Amandeep Kaur et al.
Gagandeep Kaur et al.
Alzheimer's disease (AD) is a neurological disorder characterized by a spectrum of symptoms such as memory loss and cognitive decline. AD is a multifaceted disease, and designing multipotent ligands is an effective strategy for AD treatment...
ULK1 Knockout Exacerbates Ischemia-Induced Microglial Dysfunction via TRAF6/NF-κB Signaling Pathway [0.03%]
ULK1敲除通过TRAF6/NF-κB信号通路加剧缺血诱导的小胶质细胞功能障碍
Ye Xiong,Zhuo Li Li,Xiao Wan Wang et al.
Ye Xiong et al.
Activated microglia rapidly migrate to the infarct site, mediate neuroinflammation, and phagocytose cell debris during the acute stage of ischemic stroke; however, the underlying mechanisms remain unclear. In this study, we utilized a corti...
Exploring the Therapeutic Potential of Ar-tur in Alzheimer Disease: A Cheminformatics, Pharmacokinetics, and System Pharmacology Approach [0.03%]
基于化学信息学、药代动力学与系统药理学的石菖蒲治疗阿尔茨海默病潜力探索研究
Reiya Bosco Don Bosco,Johnson Retnaraj Samuel Selvan Christyraj,Jenif Leo Anandharaj et al.
Reiya Bosco Don Bosco et al.
Acquisition and consolidation of recognition memory involves dopaminergic activity, which is determined to be dysregulated in Alzheimer disease (AD). Aromatic turmerone (Ar-tur), one of the major bioactive components of Curcuma longa, has b...
Psychedelics, Spirituality, and Fundamentalism: A Brain Network Approach to Cognitive Flexibility and Rigidity [0.03%]
psychedelia，精神主义和原教旨主义：认知灵活性和僵化的脑网络方法
Anjian Yang,Xinyou Lv,Hongshuang Wang et al.
Anjian Yang et al.
This viewpoint reconceptualizes mysticism and fundamentalism as brain network disorders, with psychedelics like psilocybin, lysergic acid diethylamide, and N,N-dimethyltryptamine offering potential to modulate these states. By disrupting ri...
Investigation of Methylsulfonamide's Capability to Prevent Zn2+-Induced Aβ Peptide Aggregation Based on Zn2+ Coordination within the Zinc Binding Region of Aβ for Treatment of Alzheimer's Disease (AD) [0.03%]
基于Zn2+在Aβ金属结合区的配位研究甲磺酰胺防止Zn2+-诱导的Aβ肽聚集的能力以治疗阿尔茨海默病（AD）
Demet Ataman Sadık,Cemre Sare Cansız,Merve Turğut et al.
Demet Ataman Sadık et al.
There is no cure for Alzheimer's disease (AD) with the currently suggested therapies. Thus, designing and synthesis of new drugs for the treatment of Alzheimer's disease for safe and effective therapy have become an important task. Metal io...