Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors [0.03%]
度洛西汀和阿米替林通过α1-和α2-肾上腺素受体抑制脊髓背角神经元的主要感觉输入来减轻神经病理性疼痛
Yuying Huang,Hong Chen,Shao-Rui Chen et al.
Yuying Huang et al.
Antidepressants, such as duloxetine and amitriptyline, are effective for treating patients with chronic neuropathic pain. Inhibiting norepinephrine and serotonin transporters at presynaptic terminals raises extracellular concentrations of n...
Development of a Novel Electrochemiluminescence ELISA for Quantification of α-Synuclein Phosphorylated at Ser129 in Biological Samples [0.03%]
一种新型电化学发光酶联免疫吸附测定法的开发，用于量化生物样本中丝氨酸129磷酸化α-突触核蛋白
Suman Dutta,Simon Hornung,Hash Brown Taha et al.
Suman Dutta et al.
Synucleinopathies are a group of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases are characterized by the aggregation and deposition of α-syn...
Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways [0.03%]
洛伐他汀诱导U251胶质母细胞瘤细胞凋亡及其机制研究
Xiaoyi Shi,Meng Li,Qiming Huang et al.
Xiaoyi Shi et al.
Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus Monascus, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclea...
ALS-Linked A315T and A315E Mutations Enhance β-Barrel Formation of the TDP-43307-319 Hexamer: A REST2 Simulation Study [0.03%]
A315T和A315E突变体通过REST2分子动力学模拟增强TDP-43307-319六聚体β barrel结构：一种基于REST2的模拟研究
Xianshi Liu,Xuhua Li,Qin Qiao et al.
Xianshi Liu et al.
Pathogenic mutations of transactivation response element DNA-binding protein 43 (TDP-43) are closely linked with amyotrophic lateral sclerosis (ALS). It was recently reported that two ALS-linked familial mutants A315T and A315E of TDP-43307...
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress [0.03%]
慢性应激所致行为和电生理学改变的控制中的突触ATP释放增强和CD73介导的细胞外腺苷形成
Liliana Dias,Daniela Pochmann,Cristina Lemos et al.
Liliana Dias et al.
Increased ATP release and its extracellular catabolism through CD73 (ecto-5'-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood and memory dysfunc...
MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis: New Clinical Insights [0.03%]
MAGI2-AS3和miR-374b-5p通过调节PTEN/AKT/IRF-3/IFN-β轴可能成为多发性硬化症的潜在调控因子：新的临床见解
Mona A Kortam,Nourhan Elfar,Olfat G Shaker et al.
Mona A Kortam et al.
Multiple sclerosis (MS) is a chronic disease and one of the leading causes of disability in young adults. The current study aims to investigate the pathogenesis of MS via studying the regulatory role of novel lncRNA MAGI2-AS3 in miR-374b-5p...
Short-Chain Fatty Acids in the Microbiota-Gut-Brain Axis: Role in Neurodegenerative Disorders and Viral Infections [0.03%]
微生物群-肠-脑轴中的短链脂肪酸：在神经退行性疾病和病毒感染中的作用
Atreye Majumdar,Indira Priya Siva Venkatesh,Anirban Basu
Atreye Majumdar
The gut-brain axis (GBA) is the umbrella term to include all bidirectional communication between the brain and gastrointestinal (GI) tract in the mammalian body. Evidence from over two centuries describes a significant role of GI microbiome...
Repetitive Thoughts and Behaviors in Autism Spectrum Disorder: A Symptom-Based Framework for Novel Therapeutics [0.03%]
自闭症谱系障碍中的重复性思维和行为：用于新型治疗的基于症状的框架
Robyn P Thom,Christopher J McDougle
Robyn P Thom
While the core symptoms of autism spectrum disorder include repetitive thoughts and repetitive behaviors, repetitive phenomena also occur in many other psychiatric disorders. Types of repetitive thoughts include preoccupations, ruminations,...
The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential [0.03%]
大蒜（Allium sativum）在帕金森病的药理活性：从分子机制到治疗潜力
Debarati Rakshit,Sudipta Nayak,Snehashis Kundu et al.
Debarati Rakshit et al.
Parkinson's disease (PD), one of the most common neurological diseases worldwide, is mainly characterized neuropathologically by the dopaminergic neurodegeneration in the substantia nigra pars compacta of the brainstem. Genetic and environm...
Plantamajoside Alleviates Substantia Nigra Damage in Parkinson's Disease Mice by Inhibiting HDAC2/MAPK Signaling and Reducing Microglia Polarization [0.03%]
植物麻黄素通过抑制HDAC2/MAPK信号传导和减少小胶质细胞极化来减轻帕金森病小鼠黑质损害
Xiaoyuan Guo,Lukui Chen,Jianxia Li
Xiaoyuan Guo
Parkinson's disease (PD) is a common neurodegenerative disorder caused by dopaminergic neuron progressive degeneration. Inhibition of microglial activation may contribute to the treatment and prevention of PD. Plantamajoside (PMS) is a natu...