Curcumin Modulates p62-Keap1-Nrf2-Mediated Autophagy in Rotenone-Induced Parkinson's Disease Mouse Models [0.03%]
姜黄素通过调节自噬缓解罗通定致小鼠帕金森病模型中的病理损伤：p62-Keap1-Nrf2轴介导的机制研究
Aaina Singh Rathore,Saumitra Sen Singh,Hareram Birla et al.
Aaina Singh Rathore et al.
Autophagy mediates self-digestion of abnormally aggregated proteins and organelles present in the cytoplasm. This mechanism may prove to be neuroprotective against Parkinson's disease (PD) by clearing misfolded α-synuclein (α-syn) aggrega...
Mitochondrial Complex I as a Pathologic and Therapeutic Target for Parkinson's Disease [0.03%]
线粒体复合物I——帕金森病的病理和治疗靶点
Kamatham Pushpa Tryphena,Uppala Sai Nikhil,Poojitha Pinjala et al.
Kamatham Pushpa Tryphena et al.
The prevalence of Parkinson's disease (PD) continues to increase despite substantial research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a vital role in PD etiology. A disturbance in the electron transport...
JNK Activation in Alzheimer's Disease Is Driven by Amyloid β and Is Associated with Tau Pathology [0.03%]
淀粉样蛋白驱动的JNK在阿尔茨海默病中的激活与tau病理改变相关
Maite Solas,Silvia Vela,Cristian Smerdou et al.
Maite Solas et al.
c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative disorders, especially in Alzheimer's disease (AD). However, it remains unclear whether JNK or amyloid β (Aβ) appears first in the disease onset. Postmor...
Distinct Effects of Methamphetamine Isomers on Limbic Norepinephrine and Dopamine Transmission in the Rat Brain [0.03%]
甲胺phetamine异构体对大鼠脑边缘系统去甲肾上腺素和多巴胺传递的不同影响
Ryan C Pauly,Rohan V Bhimani,Jun-Xu Li et al.
Ryan C Pauly et al.
Methamphetamine (METH) is a psychostimulant that primarily exerts its effects on the catecholamine (dopamine (DA) and norepinephrine (NE)) systems, which are implicated in drug addiction. METH exists as two distinct enantiomers, dextrorotat...
Differential Binding and Conformational Dynamics of Tau Microtubule-Binding Repeats with a Preformed Amyloid-β Fibril Seed [0.03%]
Tau微管结合重复序列与预制的淀粉样蛋白-β原纤维种子的不同结合和构象动力学
Zhiyuan Song,Adam J Gatch,Yunxiang Sun et al.
Zhiyuan Song et al.
Both senile plaques formed by amyloid-β (Aβ) and neurofibrillary tangles (NFTs) comprised of tau are pathological hallmarks of Alzheimer's disease (AD). The accumulation of NFTs better correlates with the loss of cognitive function than s...
Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors [0.03%]
乙醇代谢产物醋酸通过激活中心杏仁核神经元的NMDA受体提高中枢神经系统兴奋性
Andrew D Chapp,Andréa R Collins,Kyle M Driscoll et al.
Andrew D Chapp et al.
The central nucleus of the amygdala (CeA) is a key brain region involved in emotional and stressor responses due to its many projections to autonomic regulatory centers. It is also a primary site of action from ethanol consumption. However,...
Anti-Strychnine Immunoconjugate Reduces the Effects of Strychnine-Induced Toxicity in Mice [0.03%]
抗马钱子碱免疫缀合物降低马钱子碱诱导的小鼠毒性作用
Carly Baehr,Andrew J Kassick,Jennifer Vigliaturo et al.
Carly Baehr et al.
Strychnine poisoning induces seizures that result in loss of control of airway muscles, leading to asphyxiation and subsequent death. Current treatment options are limited, requiring hands-on medical care and isolation to low-stimulus envir...
Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent Pyroptosis [0.03%]
Pink1介导的线粒体自噬抑制通过激活Caspase-3/GSDME依赖性炎性细胞焦亡参与术后认知功能障碍的发展
Wei Wang,Bo Zhao,Wenwei Gao et al.
Wei Wang et al.
PTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, gasdermin E (GSDME), another recently ...
Small-Molecule Cdc25A Inhibitors Protect Neuronal Cells from Death Evoked by NGF Deprivation and 6-Hydroxydopamine [0.03%]
小分子Cdc25A抑制剂可保护神经元细胞免受神经营养因子剥夺和6-羟基多巴胺诱导的死亡作用
Sumit Kumar Pramanik,Priyankar Sanphui,Anoy Kumar Das et al.
Sumit Kumar Pramanik et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative diseases that are presently incurable. There have been reports of aberrant activation of cell cycle pathways in neurodegenerative diseases. Prev...
14-3-3ζ Participates in the Phase Separation of Phosphorylated and Glycated Tau and Modulates the Physiological and Pathological Functions of Tau [0.03%]
14-3-3ζ参与tau蛋白磷酸化及糖基化的相分离并调节tau蛋白的生理和病理功能
Yu-Qing Liu,Chu-Qiao Liang,Zhi-Wei Chen et al.
Yu-Qing Liu et al.
Tau plays a major role in Alzheimer's disease (AD) and several other neurodegenerative diseases. Tau undergoing liquid-liquid phase separation (LLPS) performs specific physiological functions, induces pathological processes, and contributes...