Early Life Exposure to C16-Ceramide Improves Learning and Short-Term Memory Behavior during Adulthood in Mice [0.03%]
生命早期暴露于C16-丝氨醇糖脂可改善小鼠成年期的学习能力及短期记忆功能
Chia-Min Yeh,Yun-Ya Sun,Ting-Yu Chen et al.
Chia-Min Yeh et al.
Ceramides, structural components of the cell, are known to play a range of roles in glucose metabolism and apoptosis. C16-ceramide, an abundant molecular species of endogenous ceramide, has not had its influence on learning and memory explo...
Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone [0.03%]
由体内衍生的原纤维促进的淀粉样蛋白-Aβ自我装配的分子机制及BRICHOS分子伴侣的抑制效应
Rakesh Kumar,Luis Enrique Arroyo-García,Shaffi Manchanda et al.
Rakesh Kumar et al.
Self-replication of amyloid-β-peptide (Aβ) fibril formation is a hallmark in Alzheimer's disease (AD). Detailed insights have been obtained in Aβ self-assembly in vitro, yet whether similar mechanisms are relevant in vivo has remained el...
Ao Yun Zhang,Chad M Dashnaw,Mayte Gonzalez et al.
Ao Yun Zhang et al.
The heterodimerization of wild-type (WT) Cu, Zn superoxide dismutase-1 (SOD1) and mutant SOD1 might be a critical step in the pathogenesis of SOD1-linked amyotrophic lateral sclerosis (ALS). Post-translational modifications that accelerate ...
Attenuation of Stimulated Accumbal Dopamine Release by NMDA Is Mediated through Metabotropic Glutamate Receptors [0.03%]
NMDA对伏核多巴胺能神经元兴奋效应的拮抗作用受代谢型谷氨酸受体介导
Felicity S E Spencer,Maria Glodkowska,Anna I Sebold et al.
Felicity S E Spencer et al.
Electrically stimulated dopamine release from the nucleus accumbens is attenuated following application of N-methyl-d-aspartate (NMDA), which is likely to be mediated indirectly through intermediary neuronal mechanisms rather than by a dire...
Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection [0.03%]
C9ORF72突变衍生的有毒二肽重复蛋白通过20S蛋白酶体激活而降解恢复细胞蛋白质稳态并产生神经保护作用
Allison S Vanecek,Jelena Mojsilovic-Petrovic,Robert G Kalb et al.
Allison S Vanecek et al.
A hexanucleotide repeat expansion (HRE) in an intron of gene C9ORF72 is the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. The HRE undergoes noncanonical translation (repeat-associated non-ATG trans...
Dual Molecules Targeting 5-HT6 and GABA-A Receptors as a New Approach to Combat Depression Associated with Neuroinflammation [0.03%]
双重靶向5-HT６和GABAA受体的小分子治疗神经炎症相关抑郁的新策略研究
Monika Marcinkowska,Barbara Mordyl,Agata Siwek et al.
Monika Marcinkowska et al.
While monoaminergic deficits are evident in all depressed patients, nonresponders are characterized by impaired GABA-ergic signaling and the simultaneous presence of the inflammatory component. Pharmacological agents able to curb pathologic...
High-Affinity Fluorescent Probes for the Detection of Soluble and Insoluble Aβ Deposits in Alzheimer's Disease [0.03%]
用于阿尔茨海默病可溶性和不可溶性Aβ沉积检测的高亲和力荧光探针
Rathnam Mallesh,Juhee Khan,Prabir Kumar Gharai et al.
Rathnam Mallesh et al.
The overproduction and deposition of the amyloid-β (Aβ) aggregates are accountable for the genesis and development of the neurologic disorder Alzheimer's disease (AD). Effective medications and detection agents for AD are still deficient....
The Anthocyanidin Peonidin Interferes with an Early Step in the Fibrillation Pathway of α-Synuclein and Modulates It toward Amorphous Aggregates [0.03%]
花青素peonidin干扰α-突触核蛋白纤维化途径的早期阶段并将其调节为无定形聚集体
Geetika Verma,Rajiv Bhat
Geetika Verma
Parkinson's disease (PD) is characterized by progressive degeneration of the dopaminergic neurons in the brain, accompanied by the accumulation of proteinaceous inclusions, Lewy bodies (LB), mainly comprised of alpha synuclein (α-syn) aggr...
Mechanistic Insights into the Binding of Different Positron Emission Tomography Tracers to Chronic Traumatic Encephalopathy Tau Protofibrils [0.03%]
不同正电子发射断层扫描示踪剂与慢性创伤性脑病tau原纤维结合的机制研究
Bote Qi,Jingwang Tan,Yunxiang Sun et al.
Bote Qi et al.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, and it is neuropathologically defined as the accumulation of abnormally hyperphosphorylated tau (p-tau). Early detect...
Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review [0.03%]
乳铁蛋白在阿尔茨海默病和帕金森病中的神经保护作用：叙述性综述
Shin Jie Yong,Abhimanyu Veerakumarasivam,Wei Ling Lim et al.
Shin Jie Yong et al.
Recent advancements in lactoferrin research have uncovered that lactoferrin does function not only as an antimicrobial protein but also as an immunomodulatory, anticancer, and neuroprotective agent. Focusing on neuroprotection, this literat...