Identifying Neural Signatures of Dopamine Signaling with Machine Learning [0.03%]
利用机器学习识别多巴胺信号的神经特征
Siamak K Sorooshyari,Nicholas Ouassil,Sarah J Yang et al.
Siamak K Sorooshyari et al.
The emergence of new tools to image neurotransmitters, neuromodulators, and neuropeptides has transformed our understanding of the role of neurochemistry in brain development and cognition, yet analysis of this new dimension of neurobiologi...
Crosstalk between Adult Hippocampal Neurogenesis and Its Role in Alzheimer's Disease [0.03%]
成人海马神经发生及其在阿尔茨海默病中的作用的串扰
Virendra Tiwari,Akanksha Mishra,Sonu Singh et al.
Virendra Tiwari et al.
The functional and developmental unit of neurogenesis is neural stem cells (NSCs). These NSCs have self-renewal capacity and produce new neurons throughout life in different neurogenic niche. Neurogenesis in adult brain is associated with s...
Quantitation of Brain and Blood Glutathione and Iron in Healthy Age Groups Using Biophysical and In Vivo MR Spectroscopy: Potential Clinical Application [0.03%]
健康年龄组的大脑和血液谷胱甘肽及铁的生物物理和体内磁共振波谱定量研究及其潜在临床应用价值
Pravat K Mandal,Divya Dwivedi,Shallu Joon et al.
Pravat K Mandal et al.
The antioxidant glutathione (GSH) and pro-oxidant iron levels play a balancing role in the modulation of oxidative stress (OS). There is a significant depletion of GSH in the left hippocampus (LH) in patients with Alzheimer's disease (AD) w...
JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding [0.03%]
entorhinal皮质过表达JNK3影响海马并导致认知障碍和tau蛋白错误折叠
Carlos G Ardanaz,Amaia Ezkurdia,Arantza Bejarano et al.
Carlos G Ardanaz et al.
c-Jun N-terminal kinases (JNKs) are a family of protein kinases activated by a myriad of stimuli consequently modulating a vast range of biological processes. In human postmortem brain samples affected with Alzheimer's disease (AD), JNK ove...
Gayani Wijegunawardena,Erika Castillo,Brandy Henrickson et al.
Gayani Wijegunawardena et al.
Mutations in a microglia-associated gene TREM2 increase the risk of Alzheimer's disease. Currently, structural and functional studies of TREM2 mainly rely on recombinant TREM2 proteins expressed from mammalian cells. However, using this met...
Ritu Soni,Prashant Delvadia,Amit Joharapurkar et al.
Ritu Soni et al.
Parkinson's disease (PD) is the second most prevailing progressive disorder leading to neurodegeneration, typically in people above 65 years of age. Motor clinical manifestations of PD appear in a much later stage and include rigidity, trem...
Cannabidiol Protects Dopaminergic-like Neurons against Paraquat- and Maneb-Induced Cell Death through Safeguarding DJ-1CYS106 and Caspase 3 Independently of Cannabinoid Receptors: Relevance in Parkinson's Disease [0.03%]
cannabidiol通过独立于大麻素受体的机制保护多巴胺能神经元免受百草枯和曼奈博诱发的细胞死亡：帕金森病的相关性
Miguel Mendivil-Perez,Andrea A Felizardo-Otalvaro,Marlene Jimenez-Del-Rio et al.
Miguel Mendivil-Perez et al.
Parkinson's disease (PD), a progressive neurodegenerative movement disorder, has reached pandemic status worldwide. This neurologic disorder is caused primarily by the specific deterioration of dopaminergic (DAergic) neurons in the substant...
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease [0.03%]
用于阿尔茨海默病治疗的蛋白水解靶向嵌合体诱导糖原合成酶激酶3β降解策略
Melissa Guardigni,Letizia Pruccoli,Alan Santini et al.
Melissa Guardigni et al.
Glycogen synthase kinase 3β (GSK-3β) is a serine/threonine kinase and an attractive therapeutic target for Alzheimer's disease. Based on proteolysis-targeting chimera (PROTAC) technology, a small set of novel GSK-3β degraders was designe...
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for Alzheimer's Disease Therapy [0.03%]
作为潜在的阿尔茨海默病治疗多靶向配体的5-苯基-1,3,4-噁二唑-2-硫醇类哌嗪和N-苯基哌啶杂化物的设计、合成及生物活性评估
Digambar Kumar Waiker,Akash Verma,Akhilesh et al.
Digambar Kumar Waiker et al.
Our present work demonstrates the successful design and synthesis of a new class of compounds based upon a multitargeted directed ligand design approach to discover new agents for use in Alzheimer's disease (AD). All the compounds were test...
Role of Imaging Modalities and N-Acetylcysteine Treatment in Sepsis-Associated Encephalopathy [0.03%]
影像学在脓毒血症相关性脑病诊断及N-乙酰半胱氨酸治疗中的作用研究
Yazhi Zhong,Jitian Guan,Yunfeng Ma et al.
Yazhi Zhong et al.
Sepsis-associated encephalopathy is a severe systemic infection complication. Although early stages involve pathophysiological changes, detection using conventional imaging is challenging. Glutamate chemical exchange saturation transfer and...