Aptamer Reduces Aggregation of Mutant Huntingtin and Rescues Proteostasis Network in Non-Neuronal and Neuronal Cells [0.03%]
适配体可减少突变型亨廷顿蛋白的聚集并缓解非神经元和神经元细胞中的蛋白质稳态网络损伤
Swati Jain,Ipsita Roy
Swati Jain
Aggregation of mutant huntingtin is a pathological hallmark of Huntington's disease (HD). Protein aggregation results in various cellular dysfunctions, such as increase in oxidative stress, mitochondrial damage, proteostasis imbalance, etc....
HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke [0.03%]
外周血来源的携带HABP2的外泌体通过抑制缺血性脑卒中小胶质细胞自噬加重神经炎症损伤
Hongcheng Luo,Qiang Huang,Deyou Huang et al.
Hongcheng Luo et al.
Exosomes are shown to be involved in the regulation of neuroinflammatory injury. The current study analyzed how peripheral blood-derived exosomes affected hyaluronan-binding protein 2 (HABP2) expression to regulate neuroinflammatory injury ...
Elliot W McClure,R Nathan Daniels
Elliot W McClure
Dextromethorphan (DXM) was introduced in 1958 as the first non-opioid cough suppressant and is indicated for multiple psychiatric disorders. It has been the most used over-the-counter cough suppressant since its emergence. However, individu...
Unraveling the Connection of Epstein-Barr Virus and Its Glycoprotein M146-157 Peptide with Neurological Ailments [0.03%]
解密EB病毒及其糖蛋白M146-157肽与神经性疾病的关系
Priyanka Patra,Annu Rani,Neha Sharma et al.
Priyanka Patra et al.
Epstein-Barr virus (EBV) is known to be associated with several cancers along with neurological modalities like Alzheimer's disease (AD) and multiple sclerosis (MS). Previous study from our group revealed that a 12 amino acid peptide fragme...
Disease-Modifying Effects of Vincamine Supplementation in Drosophila and Human Cell Models of Parkinson's Disease Based on DJ-1 Deficiency [0.03%]
基于DJ-1缺乏的帕金森病果蝇和人类细胞模型中长春胺补充的疾病修饰效应
Francisco José Sanz,Cristina Solana-Manrique,Nuria Paricio
Francisco José Sanz
Parkinson's disease (PD) is an incurable neurodegenerative disorder caused by the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Current therapies are only symptomatic and are not able to stop or delay its pro...
Hypoxic Preconditioning Modulates BDNF and Its Signaling through DNA Methylation to Promote Learning and Memory in Mice [0.03%]
缺氧预处理通过DNA甲基化调控BDNF及其信号转导促进小鼠学习和记忆能力
Shiji Zhang,Weng Fu,Xiaoe Jia et al.
Shiji Zhang et al.
Hypoxic preconditioning (HPC) as an endogenous mechanism can resist hypoxia/ischemia injury and exhibit protective effects on neurological function including learning and memory. Although underlying molecular mechanisms remain unclear, HPC ...
Mitochondrial-Derived Peptide MOTS-c Ameliorates Spared Nerve Injury-Induced Neuropathic Pain in Mice by Inhibiting Microglia Activation and Neuronal Oxidative Damage in the Spinal Cord via the AMPK Pathway [0.03%]
线粒体衍生肽MOTS-c通过AMPK通路抑制脊髓小胶质细胞激活和神经元氧化损伤缓解小鼠坐骨神经切断术引起的神经病理性疼痛
Jinhong Jiang,Lingfei Xu,Long Yang et al.
Jinhong Jiang et al.
MOTS-c, a recently discovered mitochondrial-derived peptide, plays an important role in many physiological and pathological functions via adenosine monophosphate-activated protein kinase (AMPK) activation. Numerous studies have demonstrated...
Concentration of Phosphatidylserine Influence Rates of Insulin Aggregation and Toxicity of Amyloid Aggregates In Vitro [0.03%]
磷脂酰丝氨酸浓度影响胰岛素聚集速率及体外淀粉样聚集毒性速率
Mikhail Matveyenka,Kiryl Zhaliazka,Dmitry Kurouski
Mikhail Matveyenka
Phosphatidylserine (PS) is a negatively charged lipid that plays a critically important role in cell apoptosis. Under physiological conditions, PS is localized on the cytosolic side of plasma membranes via ATP-dependent flippase-mediated tr...
A Student Perspective on the 18th Monitoring Molecules in Neuroscience Meeting in Lyon [0.03%]
第十八届神经科学中的分子监测会议在里昂召开——学生视角观点
Alexandra G Forderhase,Laney C Kimble,Leslie A Sombers
Alexandra G Forderhase
After being postponed twice due to the global COVID-19 pandemic, approximately 200 scientists gathered in Lyon, France, in late June 2022 for the 18th Biennial Monitoring Molecules in Neuroscience (MMiN) Research Conference. Although there ...
Proteomic Study on the Mechanism of Arsenic Neurotoxicity in the Rat Cerebral Cortex and the Protective Mechanism of Dictyophora Polysaccharides against Arsenic Neurotoxicity [0.03%]
Dictyophora多糖通过调节蛋白质磷酸化水平对砷所致神经毒性的保护机制及作用机理的蛋白组学研究
Xinglai Zhang,Hongmei Yang,Yi Wang et al.
Xinglai Zhang et al.
Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been reported to reduce the toxicity of As. In this study, As pois...