Electroosmotic Perfusion, External Microdialysis: Simulation and Experiment [0.03%]
电渗灌注和外源微透析：理论与实验研究
Michael T Rerick,Jun Chen,Stephen G Weber
Michael T Rerick
Information about the rates of hydrolysis of neuropeptides by extracellular peptidases can lead to a quantitative understanding of how the steady-state and transient concentrations of neuropeptides are controlled. We have created a small mi...
Blocking Pannexin-1 Channels Alleviates Thalamic Hemorrhage-Induced Pain and Inflammatory Depolarization of Microglia in Mice [0.03%]
阻断Pannexin-1通道可缓解小鼠丘脑出血引起的疼痛和小胶质细胞炎症去极化
Fan Bu,Yuerong Li,Shiming Lan et al.
Fan Bu et al.
Central post-stroke pain (CPSP) is a neuropathic pain syndrome that frequently occurs following cerebral stroke. The pathogenesis of CPSP is mainly due to thalamic injury caused by ischemia and hemorrhage. However, its underlying mechanism ...
Development of a Novel [11C]CO-Labeled Positron Emission Tomography Radioligand [11C]BIO-1819578 for the Detection of O-GlcNAcase Enzyme Activity [0.03%]
一种新的[11C]CO标记的正电子发射断层成像放射性配体[11C]BIO-1819578用于检测O-GlcNA酶活性的发展
Sangram Nag,Martin Bolin,Prodip Datta et al.
Sangram Nag et al.
Imaging O-GlcNAcase OGA by positron emission tomography (PET) could provide information on the pathophysiological pathway of neurodegenerative diseases and important information on drug-target engagement and be helpful in dose selection of ...
Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of O2 after Brain Injury [0.03%]
地塞米松增强的连续在线微透析技术在脑损伤后神经监测中的应用研究
Elaine M Robbins,Andrea S Jaquins-Gerstl,David O Okonkwo et al.
Elaine M Robbins et al.
Traumatic brain injury (TBI) is a major public health crisis in many regions of the world. Severe TBI may cause a primary brain lesion with a surrounding penumbra of tissue that is vulnerable to secondary injury. Secondary injury presents a...
Molecular Characterization of Two Wamide Neuropeptide Signaling Systems in Mollusk Aplysia [0.03%]
软体动物海兔中两种Wamide神经肽信号系统的分子特征分析
Hui-Ying Wang,Ke Yu,Wei-Jia Liu et al.
Hui-Ying Wang et al.
Neuropeptides with the C-terminal Wamide (Trp-NH2) are one of the last common ancestors of peptide families of eumetazoans and play various physiological roles. In this study, we sought to characterize the ancient Wamide peptides signaling ...
Dopamine Release Impairments Accompany Movement Vigor Deficiency in an Exercise-Induced Fatigue Mouse Model [0.03%]
运动无力伴随多巴胺释放障碍小鼠模型中的运动活力缺陷
Xin Yang,Yifei Xue,Ran Liu et al.
Xin Yang et al.
Fatigue is a common symptom in neurological diseases with a complex cause, involving the influence of events occurring in both the central and peripheral nervous systems. When people suffer from fatigue, a general decline in their movement ...
Myricetin: A Potent Anti-Amyloidogenic Polyphenol against Superoxide Dismutase 1 Aggregation [0.03%]
茋类化合物檞皮素是一种有效的SOD1聚集抑制剂
Shilpa Sharma,Vijay Raj Tomar,Shashank Deep
Shilpa Sharma
Amyotrophic lateral sclerosis (ALS) is believed to be caused by the aggregation of misfolded or mutated superoxide dismutase 1 (SOD1). As there is currently no treatment, research into aggregation inhibitors continues. Based on docking, mol...
Clinical Radiosynthesis and Translation of [18F]OP-801: A Novel Radiotracer for Imaging Reactive Microglia and Macrophages [0.03%]
新型放射示踪剂[18F]OP-801的临床合成及其用于活体成像小胶质细胞和巨噬细胞活化的转化研究
Isaac M Jackson,Mackenzie L Carlson,Corinne Beinat et al.
Isaac M Jackson et al.
Positron emission tomography (PET) is a powerful tool for studying neuroinflammatory diseases; however, current PET biomarkers of neuroinflammation possess significant limitations. We recently reported a promising dendrimer PET tracer ([18F...
Cai Wang,Jingyi Sun,Qian Chen et al.
Cai Wang et al.
Stroke is a disease with high disability and high mortality in the world. Due to the existence of the blood-brain barrier (BBB), complex brain structure, and numerous neural signal pathways, the treatment methods are limited, so new drugs a...
Antidepressant-like Effect of 1-(2-(4-(4-Ethylphenyl)-1 H-1,2,3-triazol-1-yl)phenyl)ethan-1-one in Mice: Evidence of the Contribution of the Serotonergic System [0.03%]
一种新的苯乙酮类化合物的抗抑郁作用：五羟色胺能系统的贡献证据
Marcelo Heinemann Presa,Marcia Juciele da Rocha,Camila Simões Pires et al.
Marcelo Heinemann Presa et al.
Major depressive disorder (MDD) is a psychiatric disorder that affects a large portion of the population, with dysregulation of the serotonergic system, which is deeply involved in both the pathophysiology of MDD and mechanism of action of ...