Selective Cyclooxygenase-2 Inhibitors in Preclinical Rodent Models of Depression and Post-traumatic Stress Disorder: A Systematic Review of Behavioral, Neuroinflammatory, and Molecular Mechanisms [0.03%]
选择性环氧合酶-2抑制剂在抑郁和创伤后应激障碍的临床前小鼠模型中的系统评价：行为学、神经炎症和分子机制的观点
Alexey Sarapultsev,Maria Komelkova,Irina Utepova et al.
Alexey Sarapultsev et al.
Depression and post-traumatic stress disorder (PTSD) are treatment-resistant neuropsychiatric conditions closely linked to chronic neuroinflammation. Given the limitations of current pharmacotherapies, selective cyclooxygenase-2 (COX-2) inh...
Excitatory and Inhibitory Activity Is Differentially Affected in SOD1G37R Mouse Model of ALS: A 1H-[13C]-NMR Analysis [0.03%]
SOD1G37R小鼠模型中ALS的兴奋性和抑制性活动的影响：一种1H-[13C]-核磁共振分析
Dipak Roy,Chaynita Dashora,Anant Bahadur Patel
Dipak Roy
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder marked by the selective degeneration of motor neurons in the central nervous system. In this study, neuronal and astroglial metabolic activities were evaluated in the cereb...
Divalent and Trivalent Metallic Ions Differentially Affect Alpha-Synuclein Aggregation [0.03%]
二价和三价金属离子对α-突触核蛋白聚集具有不同的影响
Noah J Graves,Ali K Jaafar,Yann Gambin et al.
Noah J Graves et al.
Alpha-synuclein (αSyn) is the constituent protein associated with neurodegenerative synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Recent studies have highlighted the potential role o...
Debabrata Sarkar,Sumangal Roychowdhury,Rajeev Jain et al.
Debabrata Sarkar et al.
Parkinson's disease (PD) is a progressive neurodegenerative condition that affects the brain's ability to control movement. The disease occurs when nerve cells of the brain become impaired. Alpha-synuclein protein (α-Syn) aggregation follo...
Design, Synthesis and Biological Evaluation of Chromeno[3,4- b]xanthones as Multifunctional Agents for Alzheimer's Disease [0.03%]
作为阿尔茨海默病多功能药物的杂色烯并香豆素的设计、合成及生物活性评估
Daniela Malafaia,Natércia F Brás,Anna Sampietro et al.
Daniela Malafaia et al.
Alzheimer's disease (AD) remains a complex and unmet medical challenge, requiring innovative approaches to address its multifaceted pathology. In this study, we explored chromeno[3,4-b]xanthones as a novel multifunctional scaffold, synthesi...
Membrane Partition and Structural Reorganization Induced by Antipsychotics with Distinct Clinical Profiles [0.03%]
具有不同临床特征的抗精神病药物诱发的膜分离和结构重组
Ana Gorse,Vesela Yordanova,Jessica Bodosa et al.
Ana Gorse et al.
Antipsychotics (APs) are used in the treatment of severe mental disorders. Their mechanism of action involves interaction with multiple brain targets, notably the dopamine D2 receptor (D2R), where they compete with dopamine. Due to their li...
Ummy Habiba Sweety,Mahesh Narayan
Ummy Habiba Sweety
Polyvinyl chloride (PVC) nanoplastics (NPs) exposure in humans is neurotoxic. To underscore the possible mechanisms by which PVC NPs provoke neurotoxic outcomes, we have explored the interfacial interactions between PVC NPs and biological a...
Exploring the Structural Order of Condensates Formed by the PRD2 Domain of Mouse CPEB3 [0.03%]
探究小鼠CPEB3蛋白PRD2结构域凝聚体的结构秩序
Faina Pinhero,Dhanya S Reselammal,Arunima Sandeep et al.
Faina Pinhero et al.
The maintenance of long-term memory requires sustainable synaptic connections mediated by the prion-like transformation of the translational regulator protein CPEB3 (cytoplasmic polyadenylation element binding protein isoform 3) in mammals....
Targeting the Dectin-1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders [0.03%]
靶向β-葡聚糖受体Dectin-1在神经炎症中的作用及对神经精神障碍的治疗意义
Edna F do Nascimento,Pauliane V C Batista,Carla S Cunha et al.
Edna F do Nascimento et al.
Exploring the role of the pattern recognition receptor Dectin-1 in neurological diseases emerges as an important target for understanding the biochemical and physiological dynamics of neuropathologies. From this perspective, Dectin-1, prote...
Multimodal Nano-DESI Mass Spectrometry Imaging Reveals Phospholipids Accumulation in and around Amyloid Plaques in Alzheimer's Disease [0.03%]
多重模式纳米解吸电喷雾离子化质谱成像揭示阿尔茨海默病淀粉样斑块内外磷脂的聚集
Manxi Yang,Xindi Tang,Mushfeqa Iqfath et al.
Manxi Yang et al.
Alzheimer's disease (AD), characterized by β-amyloid plaques, is increasingly recognized by lipid dysregulation as a key factor in its pathology. Mass spectrometry imaging (MSI), a powerful tool for mapping the spatial distribution of biom...