Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates [0.03%]
用于监测非人灵长类动物电化学神经活动的微侵入式探针
Usamma Amjad,Shreya Mahajan,Jiwon Choi et al.
Usamma Amjad et al.
We leveraged carbon fiber materials for creating sensors that provide dual neurochemical and electrical neural activity recording at microinvasive (10 μm) spatial footprints proximal to recording sites, and enabling these measurements from...
Discovery of Carbazole and Theophylline-Based Amyloid Inhibitor for the Promotion of Neuroprotection [0.03%]
carbazole和theophylline类淀粉抑制剂的发现以促进神经保护
Prabir Kumar Gharai,Juhee Khan,Rathnam Mallesh et al.
Prabir Kumar Gharai et al.
The amyloid-beta 42 (Aβ42) peptide assembles into neurotoxic soluble oligomers and extracellular fibrillary aggregates during the progression of Alzheimer's disease (AD), which ultimately leads to amyloid plaque in the brain, causing major...
Prediction of Specificity of α-Conotoxins to Subtypes of Human Nicotinic Acetylcholine Receptors with Semi-supervised Machine Learning [0.03%]
半监督机器学习预测α-康拓辛特异性作用于人源烟碱型乙酰胆碱受体亚型
Hung Nguyen Do,Jessica Z Kubicek-Sutherland,Sandrasegaram Gnanakaran
Hung Nguyen Do
Conotoxins are a family of highly toxic neurotoxins composed of cysteine-rich peptides produced by marine cone snails. The most lethal cone snail species to humans is Conus geographus, with fatality rates of up to ∼65% from a single sting,...
Dl-3- n-Butylphthalide Alleviates Cognitive Impairment in Chronic Cerebral Hypoperfusion: Associations with Mitochondrial Permeability Transition Pore Closure and Suppression of Excessive Mitophagy [0.03%]
DL-3-正丁基苯酞通过调节线粒体动态平衡改善慢性脑低灌注大鼠认知障碍的作用及机制研究
Yaqiong Li,Junkui Shang,Huiwen Zhang et al.
Yaqiong Li et al.
Chronic cerebral hypoperfusion (CCH) results in cognitive impairment, with mitochondrial dysfunction identified as a key contributor. The opening of the mitochondrial permeability transition pore (mPTP) is closely associated with mitochondr...
Mechanisms of Alpha-Synuclein-Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging [0.03%]
荧光寿命成像揭示了α-突触核蛋白原纤维诱导的神经元内蛋白质聚集机制
Paula-Marie E Ivey,Magaly Guzman Sosa,Abdelrahman Salem et al.
Paula-Marie E Ivey et al.
The brains of Parkinson's disease (PD) patients are characterized by the presence of Lewy body inclusions enriched with fibrillar forms of the presynaptic protein alpha-synuclein (aSyn). Despite related evidence that Lewy pathology spreads ...
TRPA1 siRNA-Loaded Nanoformulation Ameliorates Chemotherapy-Induced Peripheral Neuropathy [0.03%]
负载TRPA1 siRNA的纳米制剂可改善化疗诱导的外周神经病变
Akhilesh,Anurag Kumar Singh,Vinod Tiwari
Akhilesh
Small interfering RNA (siRNA) has emerged as a cutting-edge therapeutic strategy, with significant promise for addressing peripheral neuropathies. Despite its immense revolutionary therapeutic potential, the application and sustained releas...
Reactive Astrocytes with Reduced Function of Glutamate Transporters in the AppNL-G-F Knock-in Mice [0.03%]
谷氨酸转运蛋白功能下降的反应性星形胶质细胞在AppNL-G-F敲入小鼠中的作用
Ipsit Srivastava,Julen Goikolea,Tamer Ayberk Kaya et al.
Ipsit Srivastava et al.
Alzheimer's disease (AD) is associated with synaptic and memory dysfunction. One of the hallmarks of AD is reactive astrogliosis, with reactive astrocytes surrounding amyloid plaques in the brain. Astrocytes have also been shown to be activ...
Molecular Insight into Amyloid Fibril-Templated Aggregation of Biomarkers [0.03%]
分子层面解析生物标志物的淀粉样纤维模板聚集效应
Rongfeng Zou,Hans Ågren
Rongfeng Zou
The aggregation of misfolded proteins into β-sheet-rich fibrils constitutes a characteristic feature of neurodegenerative disorders and represents a therapeutic target. While cryo-electron microscopy has elucidated ordered binding patterns...
Discovery of Pre-Clinical Candidate VU6008055/ AF98943: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy [0.03%]
VU6008055/AF98943的发现：一种具有高选择性、可口服给药且结构独特的三环M4胆碱能受体激动剂，具有强大的体内活性
Julie L Engers,Sean R Bollinger,Alison R Gregro et al.
Julie L Engers et al.
Herein, we report the structure-activity relationship to develop novel tricyclic M4 positive allosteric modulator scaffolds with improved pharmacological properties. This endeavor involved modifying a 5-amino-3,4-dimethylthieno[2,3-c]pyrida...
Neurotransmitter-Loaded DNA Nanocages as Potential Therapeutics for α-Synuclein-Based Neuropathies in Cells and In Vivo [0.03%]
负载神经递质的DNA纳米笼可作为细胞和活体中基于α-突触核蛋白神经退行性疾病的潜在治疗策略
Payal Vaswani,Sanjay Kosra,Krupa Kansara et al.
Payal Vaswani et al.
Parkinson's disease is one of the neuropathies characterized by accumulation of the α-synuclein protein, leading to motor dysfunction. Levodopa is the gold standard treatment; however, in long-term usage, it leads to levodopa-induced dyski...