The Partial M1 Muscarinic Cholinergic Receptor Agonist, CDD-0102A, Differentially Modulates Glutamate Efflux in Striatal Subregions during Stereotyped Motor Behavior in the BTBR Mouse Model of Autism [0.03%]
部分M1胆碱能受体激动剂CDD-0102A在BTBR自闭症小鼠模型刻板运动行为过程中不同调节纹状体内谷氨酸释放
Pamela Teneqexhi,Alina Khalid,Khalin E Nisbett et al.
Pamela Teneqexhi et al.
The BTBR T+ Itpr3tf/J (BTBR) mouse displays elevated repetitive motor behaviors. Treatment with the partial M1 muscarinic receptor agonist, CDD-0102A, attenuates stereotyped motor behaviors in BTBR mice. The present experiment investigated ...
Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer's Disease [0.03%]
源于胡椒碱的多靶点导向配体作为帽状组分用于阿尔茨海默病管理的研究发现
Kancharla Bhanukiran,Sushil Kumar Singh,Ravi Singh et al.
Kancharla Bhanukiran et al.
The naturally inspired multitarget-directed ligands (PC01-PC10 and PD01-PD26) were synthesized from piperine for the management of Alzheimer's disease (AD). The compound PD07 showed significant inhibitory activity on ChEs, BACE1, and Aβ1-4...
ALS Variants of Annexin A11's Proline-Rich Domain Impair Its S100A6-Mediated Fibril Dissolution [0.03%]
视黄醇附睾分泌蛋白A11的多聚脯氨酸变异通过干扰其与S100A6的相互作用促进其纤维聚集
Aman Shihora,Ruben D Elias,John A Hammond et al.
Aman Shihora et al.
Mutations in the proline-rich domain (PRD) of annexin A11 are linked to amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, and generate abundant neuronal A11 inclusions by an unknown mechanism. Here, we demonstrate that...
Correction to "Design, Synthesis, and Biological Evaluation of Novel Multifunctional Rolipram-Tranilast Hybrids As Potential Treatment for Traumatic Brain Injury" [0.03%]
有关罗利普拉姆-曲尼司特杂环化合物新型多功能设计、合成及生物评价以用于创伤性脑损伤的潜在治疗的更正通知书
Junfeng Lu,Chen Chen,Xiaobing Deng et al.
Junfeng Lu et al.
Published Erratum
ACS chemical neuroscience. 2023 Jul 19;14(14):2582. DOI:10.1021/acschemneuro.3c00441 2023
Structure-Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP) [0.03%]
有关最近受控的合成卡西酮多巴胺转运体再摄取抑制剂α-派洛羟基苯丙酮（α-PHP）结构活性关系的研究
Rachel A Davies,Vy T Nguyen,Jose M Eltit et al.
Rachel A Davies et al.
α-Pyrrolidinohexiophenone (α-PHP) is the one-carbon unit α-extended homolog of the better-known and widely abused synthetic cathinone central stimulant α-PVP ("flakka"); both are now U.S. Schedule I controlled substances. Structurally, ...
Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal [0.03%]
肽组学分析揭示了冬眠哺乳动物下丘脑和垂体中神经肽及肽激素的季节性变化
Somayeh Mousavi,Haowen Qiu,Matthew T Andrews et al.
Somayeh Mousavi et al.
During the winter, hibernating mammals undergo extreme changes in physiology, which allow them to survive several months without access to food. These animals enter a state of torpor, which is characterized by decreased metabolism, near-fre...
DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5- b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms [0.03%]
DM506（3-甲基-1，2，3，4，5，6-六氢化氮杂庚因富马酸盐），一种从阿博加mine衍生物抑制α7和α9α10烟碱乙酰胆碱受体的新物质，通过不同的变构机制起作用
Han-Shen Tae,Marcelo O Ortells,Bassel J Tekarli et al.
Han-Shen Tae et al.
The main objective of this study was to determine the pharmacological activity and molecular mechanism of action of DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a novel ibogamine derivative, at different nicotinic ac...
Discrimination between Alpha-Synuclein Protein Variants with a Single Nanometer-Scale Pore [0.03%]
利用纳米级孔径区分α-突触核蛋白变异体
Mazdak Afshar Bakshloo,Safia Yahiaoui,Matthieu Bourderioux et al.
Mazdak Afshar Bakshloo et al.
Alpha-synuclein is one of several key factors in the regulation of nerve activity. It is striking that single- or multiple-point mutations in the 140-amino-acid-long protein can change its structure, which leads to the protein's aggregation...
Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors [0.03%]
共价片段通过GTP交换因子抑制RhoA活化
Muhammad S Hussain,Degang Liu,Warren J Alilain et al.
Muhammad S Hussain et al.
Ras homolog gene family member (RhoA) is a GTPase and a member of the RAS superfamily of GTPases. RhoA is a master regulator of the actin cytoskeleton. It inhibits axon growth preventing repair and recovery following spinal cord and traumat...
Modulation of Acid-Sensing Ion Channels by Tannic Acid and Green Tea via a Membrane-Mediated Mechanism [0.03%]
单宁酸和绿茶通过膜介导机制调节酸感应离子通道
Ammar Hawashin,Ilka C Brakmann,Yuemin Tian et al.
Ammar Hawashin et al.
Acid-sensing ion channels (ASICs) are proton-gated ion channels that contribute to pain perception and neurotransmission. Being involved in sensing inflammation and ischemia, ASIC1a and ASIC3 are promising drug targets. Polyphenol tannic ac...