Enhanced Inhibition of Amyloid Formation by Heat Shock Protein 90 Immobilized on Nanoparticles [0.03%]
热休克蛋白90固定在纳米颗粒上增强抑制淀粉样蛋白形成的作用
Ana Rodríguez-Ramos,Jesús A González,Mónica L Fanarraga
Ana Rodríguez-Ramos
As the population ages, an epidemic of neurodegenerative diseases with devastating social consequences is looming. To address the pathologies leading to amyloid-related dementia, novel therapeutic strategies must be developed for the treatm...
Does Ketogenic Diet Used in Pregnancy Affect the Nervous System Development in Offspring?─FTIR Microspectroscopy Study [0.03%]
生酮饮食对胎鼠大脑脂质代谢影响的实验研究──FTIR微光谱分析法
Marzena Rugiel,Zuzanna Setkowicz-Janeczko,Wojciech Kosiek et al.
Marzena Rugiel et al.
Anti-seizure medications used during pregnancy may have transient or long-lasting impact on the nervous system of the offspring. Therefore, there is a great need to search for alternative therapies for pregnant women suffering from seizures...
Quantitative Assays for Catalytic Photo-Oxygenation of Alzheimer Disease-Related Tau Proteins [0.03%]
Tau蛋白阿尔茨海默病相关催化光氧定量分析法
Hiroki Umeda,Taka Sawazaki,Masahiro Furuta et al.
Hiroki Umeda et al.
Catalytic photo-oxygenation of tau amyloid is a potential therapeutic approach to tauopathies, including Alzheimer disease (AD). However, tau is a complex target containing great molecular size and heterogeneous isoforms/proteoforms. Althou...
Cdk5-Mediated Brain Unfolded Protein Response Upregulation Associated with Cognitive Impairments in Type 2 Diabetes and Ameliorative Action of NAC [0.03%]
N-乙酰半胱氨酸通过调节2型糖尿病大鼠脑内未折叠蛋白反应发挥改善认知功能的作用
Debarpita Saha,Sangita Paul,Utkarsh Gaharwar et al.
Debarpita Saha et al.
The role of cyclin-dependent kinase 5 (Cdk5) in the normal functioning of the central nervous system and synaptic plasticity is well established. However, dysregulated kinase activity can have a significant impact on neurodegeneration and c...
An FSCV Study on the Effects of Targeted Typical and Atypical DAT Inhibition on Dopamine Dynamics in the Nucleus Accumbens Shell of Male and Female Mice [0.03%]
靶向多巴胺转运体抑制对雄性和雌性小鼠伏隔核壳区多巴胺动力学影响的FSCV研究
Melinda Hersey,Andy Y Chen,Mattingly K Bartole et al.
Melinda Hersey et al.
Understanding the neurochemistry underlying sex differences in psychostimulant use disorders (PSUD) is essential for developing related therapeutics. Many psychostimulants, like cocaine, inhibit the dopamine transporter (DAT), which is larg...
Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2 [0.03%]
新型苯基乙烯脂质可作为甘氨酸受体的新型变构激动剂和甘氨酸转运蛋白2抑制剂
Casey I Gallagher,Zachary J Frangos,Diba Sheipouri et al.
Casey I Gallagher et al.
Chronic pain is a complex condition that remains resistant to current therapeutics. We previously synthesized a series of N-acyl amino acids (NAAAs) that inhibit the glycine transporter, GlyT2, some of which are also positive allosteric mod...
Designer Drug, 25D-NBOMe, Has Reinforcing and Rewarding Effects through Change of a Dopaminergic Neurochemical System [0.03%]
新型致幻剂25D-NBOMe通过多巴胺神经化学系统的变化产生觅药和奖赏效应
Jae-Gyeong Lee,Kwang-Hyun Hur,Su-Bin Hwang et al.
Jae-Gyeong Lee et al.
2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)_ethanamine (25D-NBOMe), an analogue of the 2C family, is a newly synthesized psychoactive substance. It acts as an agonist at the 5-HT2A receptor and has a similar mechanism to that of NB...
De Novo Design of a β-Helix Tau Protein Scaffold: An Oligomer-Selective Vaccine Immunogen Candidate for Alzheimer's Disease [0.03%]
从头设计tau蛋白的β-螺旋结构作为针对阿尔茨海默病的选择性寡聚免疫原候选疫苗
Adekunle Aina,Shawn C C Hsueh,Ebrima Gibbs et al.
Adekunle Aina et al.
Tau pathology is associated with many neurodegenerative disorders, including Alzheimer's disease (AD), where the spatio-temporal pattern of tau neurofibrillary tangles strongly correlates with disease progression, which motivates therapeuti...
Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease [0.03%]
计算设计的小分子可分解阿尔茨海默病致病元蛋白寡聚体和原纤维素
Yingying Jin,Matthew A Downey,Ambuj Singh et al.
Yingying Jin et al.
Alzheimer's disease (AD) is one of the world's most pressing health crises. AD is an incurable disease affecting more than 6.5 million Americans, predominantly the elderly, and in its later stages, leads to memory loss, dementia, and death....
Fluorescent Turn-On Anthracene-Based Aluminum(III) Sensor for a Therapeutic Study in Alzheimer's Disease Model of Drosophila [0.03%]
一种用于阿尔茨海默病果蝇模型治疗研究的荧光开启型蒽基铝(iii)传感器
Gautam Kumar,Ananya Srivastava,Prabhat Kumar et al.
Gautam Kumar et al.
A new anthracene-based probe (E)-N'-(1-(anthracen-9-yl)ethylidene)-2-hydroxybenzohydrazide (AHB) has been efficiently synthesized and characterized by various spectroscopic methods. It exhibits extremely selective and sensitive fluorometric...