Novel Probucol Analogue, 4,4'-Diselanediylbis (2,6-Di- tert-Butylphenol), Prevents Oxidative Glutamate Neurotoxicity In Vitro and Confers Neuroprotection in a Rodent Model of Ischemic Stroke [0.03%]
一种新型 Probucol 类似物 4,4'-Diselanediylbis(2,6-二-特丁基苯酚)通过防止氧化性谷氨酸神经毒性抑制体外并能够为动物缺血性脑卒中模型提供神经保护作用
Mauricio Tavares Jacques,Viviane de Souza,Flávio Augusto Rocha Barbosa et al.
Mauricio Tavares Jacques et al.
Oxidative glutamate toxicity is regarded as one of the injurious mechanisms associated with ischemic stroke, which represents a major health problem and requires improved pharmacological treatments. We designed and synthesized two new probu...
Synthesis and Preclinical Evaluation of Fluorinated 5-Azaindoles as CB2 PET Radioligands [0.03%]
氟化5-氨基吲哚类大麻素CB2受体放射配体的合成与药效学评估研究
Annukka Kallinen,Karine Mardon,Samuel Lane et al.
Annukka Kallinen et al.
Several classes of cannabinoid receptor type 2 radioligands have been evaluated for imaging of neuroinflammation, with successful clinical translation yet to take place. Here we describe the synthesis of fluorinated 5-azaindoles and pharmac...
Merc M Kemeh,Noel D Lazo
Merc M Kemeh
The insulin-degrading enzyme (IDE) is an evolutionarily conserved protease implicated in the degradation of insulin and amyloidogenic peptides. Most of the biochemical and biophysical characterization of IDE's catalytic activity has been co...
Characterization of Uranyl (UO22+) Ion Binding to Amyloid Beta (Aβ) Peptides: Effects on Aβ Structure and Aggregation [0.03%]
铀酰离子（UO_2^{2+}）与淀粉样蛋白前体蛋白（Aβ）肽结合的特征研究：对Aβ结构和聚集的影响
Elina Berntsson,Faraz Vosough,Andra Noormägi et al.
Elina Berntsson et al.
Uranium (U) is naturally present in ambient air, water, and soil, and depleted uranium (DU) is released into the environment via industrial and military activities. While the radiological damage from U is rather well understood, less is kno...
Aquaporin-4 Mediated Aggregation of Alzheimer's Amyloid β-Peptide [0.03%]
水通道蛋白-4介导的阿尔茨海默病淀粉样蛋白β肽聚集作用
Nikhil Maroli
Nikhil Maroli
Clearance of Alzheimer's amyloid oligomers from the brain is crucial for preventing cell toxicity. Dementia complications arise as a result of apoptosis, which is caused by peptide plaques on the lipid surface of cells. Here, we employed al...
The Double-Layered Structure of Amyloid-β Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization [0.03%]
双层结构的淀粉样蛋白-β在含有GM1的膜上催化原纤维化形成
Maho Yagi-Utsumi,Satoru G Itoh,Hisashi Okumura et al.
Maho Yagi-Utsumi et al.
Alzheimer's disease (AD) is associated with progressive accumulation of amyloid-β (Aβ) cross-β fibrils in the brain. Aβ species tightly associated with GM1 ganglioside, a glycosphingolipid abundant in neuronal membranes, promote amyloid...
New Benzodihydrofuran Derivatives Alter the Amyloid β Peptide Aggregation: Strategies To Develop New Anti-Alzheimer Drugs [0.03%]
新的苯并二氢呋喃衍生物可改变β淀粉样肽的聚集行为：开发新型抗阿尔茨海默药物的新策略
Yaíma Sánchez,Carolina Castillo,Jorge Fuentealba et al.
Yaíma Sánchez et al.
Alzheimer's disease is a neurodegenerative disorder that is the leading cause of dementia in elderly patients. Amyloid-β peptide (1-42 oligomers) has been identified as a neurotoxic factor, triggering many neuropathologic events. In this s...
Altered Secretion, Constitution, and Functional Properties of the Gastrointestinal Mucus in a Rat Model of Sporadic Alzheimer's Disease [0.03%]
阿尔茨海默病小鼠模型肠道黏液分泌、组成及其功能属性的改变
Jan Homolak,Joke De Busscher,Miguel Zambrano-Lucio et al.
Jan Homolak et al.
The gastrointestinal (GI) system is affected in Alzheimer's disease (AD); however, it is currently unknown whether GI alterations arise as a consequence of central nervous system (CNS) pathology or play a causal role in the pathogenesis. GI...
Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists [0.03%]
一组苯基烷胺5-HT2A受体激动剂的结构活性评估及偏向激动作用的深度分析
Eline Pottie,Christian B M Poulie,Icaro A Simon et al.
Eline Pottie et al.
Serotonergic psychedelics are described to have activation of the serotonin 2A receptor (5-HT2A) as their main pharmacological action. Despite their relevance, the molecular mechanisms underlying the psychedelic effects induced by certain 5...
Neuroprotective Effects of Activin A against Cerebral Ischemia/Reperfusion Injury in Mice by Enhancing Nrf2 Expression to Attenuate Neuronal Ferroptosis [0.03%]
活化素A通过增强Nrf2表达来减轻神经元铁死亡从而对小鼠脑缺血再灌注损伤产生保护作用
Fengzhi Wang,Ming Ma,Jiahui Yang et al.
Fengzhi Wang et al.
Activin A (Act A) is a member of the transforming growth factor-β (TGF-β) superfamily and can protect against ischemic cerebral injury. Ferroptosis, a newly discovered type of programmed cell death, contributes to the pathogenesis of cere...