Benzo[ d]imidazole-pyrrolo[1,2- a]pyrazine Hybrids Ameliorate Amyloid Aggregates in the Brain of Alzheimer Transgenic Mice [0.03%]
苯并二氮杂色满-吡咯并嘌呤衍生物可改善阿尔茨海默病小鼠脑内淀粉样斑块聚集现象
Minhae Cha,Anuradha Dagar,Sunhee Lee et al.
Minhae Cha et al.
Abnormal assembly of amyloid β (Aβ) in the brain is implicated in Alzheimer's disease (AD) and is associated with cognitive impairments. Since Aβ accumulation occurs in advance of the onset of clinical symptoms, identifying preventable d...
Okko Alitalo,Gemma González-Hernández,Marko Rosenholm et al.
Okko Alitalo et al.
Many mechanisms have been proposed to explain acute antidepressant drug-induced activation of TrkB neurotrophin receptors, but several questions remain. In a series of pharmacological experiments, we observed that TrkB activation induced by...
Roadmap for Postnatal Brain Maturation: Changes in Gray and White Matter Composition during Development Measured by Fourier Transformed Infrared Microspectroscopy [0.03%]
产后脑发育的路线图：傅立叶变换红外显微光谱法测量灰质和白质组成的变化
Marta Peris,Núria Benseny-Cases,Gemma Manich et al.
Marta Peris et al.
Key events in postnatal brain development, such as neuronal migration, synaptogenesis, and myelination, shape the adult brain. These events are reflected in changes in gray and white matter (GM and WM) occurring during this period. Therefor...
The Role of Protein- L-isoaspartyl Methyltransferase (PIMT) in the Suppression of Toxicity of the Oligomeric Form of Aβ42, in Addition to the Inhibition of Its Fibrillization [0.03%]
蛋白-L-异瓜尔甲基转移酶(PIMT)通过抑制寡聚体Aβ42毒性及促纤维化作用发挥神经保护效应的作用研究
Tanaya Chatterjee,Gaurav Das,Barun K Chatterjee et al.
Tanaya Chatterjee et al.
The oligomeric form of amyloid-β peptide (Aβ42) plays a crucial role in the pathogenesis of Alzheimer's disease (AD) and is responsible for cognitive deficits. The soluble oligomers are believed to be more toxic compared to the fibril for...
Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator [0.03%]
侧链修饰使α7烟碱型乙酰胆碱受体激动剂转变为I类变构调节剂
Franco Viscarra,Juan Facundo Chrestia,Yaima Sanchez et al.
Franco Viscarra et al.
The quinuclidine scaffold has been extensively used for the development of nicotinic acetylcholine receptor (nAChR) agonists, with hydrophobic substituents at position 3 of the quinuclidine framework providing selectivity for α7 nAChRs. In...
Combating Dopaminergic Neurodegeneration in Parkinson's Disease through Nanovesicle Technology [0.03%]
通过纳米囊泡技术对抗帕金森病中的多巴胺能神经退行性病变
Rubina Roy,Rajib Paul,Pallab Bhattacharya et al.
Rubina Roy et al.
Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration, resulting in dopamine depletion and motor behavior deficits. Since the discovery of L-DOPA, it has been the most prescribed drug for symptomatic relief in PD, whos...
An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression [0.03%]
一种针对氟芬太尼通用特异性的工程化人源抗体片段，可逆转卡芬太尼所致的呼吸抑制作用
Lisa M Eubanks,Tossapol Pholcharee,David Oyen et al.
Lisa M Eubanks et al.
The opioid overdose crisis primarily driven by potent synthetic opioids resulted in more than 500,000 deaths in the US over the last 20 years. Though naloxone, a short-acting medication, remains the primary treatment option for temporarily ...
Neuroprotective Effect of NO-Delivery Dinitrosyl Iron Complexes (DNICs) on Amyloid Pathology in the Alzheimer's Disease Cell Model [0.03%]
一氧化氮供体二硝基铁复合物(DNICs)对阿尔茨海默病细胞模型中淀粉样病理的神经保护作用
Wen-Han Chuang,Yu-Ting Chou,Yi-Hong Chen et al.
Wen-Han Chuang et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment, memory loss, and behavioral deficits. β-amyloid1-42 (Aβ1-42) aggregation is a significant cause of the pathogenesis in AD. Despite the numerou...
James D Greenwood,Wyatt C Powell,Maciej A Walczak
James D Greenwood
Recent studies involving four research teams have revealed that amyloid fibrils in FTLD-TDP patients and cognitively healthy individuals primarily consist of TMEM106B, a protein previously identified as a risk factor for FTLD-TDP. Through c...
HSPB8-Mediated Actin Filament Reorganization by Promoting Autophagic Flux Confers Resilience to Blood-Brain Barrier (BBB) Injury in an In Vitro Model of Ischemic Stroke [0.03%]
HSPB8通过促进自噬流介导肌动蛋白丝重组以增强血脑屏障损伤的抵抗性：一种缺血性中风体外模型研究
Fangfang Zhou,Fei Li,Ying Hou et al.
Fangfang Zhou et al.
Recently, uncontrolled actin polymerization has been recognized as an initiator of early-onset blood-brain barrier (BBB) rupture. Here, using in vitro models, we found that after oxygen-glucose deprivation/reperfusion (OGD/R), endothelial o...