Yamogenin Exhibits Antidepressant-like Effects via Inhibition of ER Stress and Microglial Activation in LPS-Induced Mice [0.03%]
甜高梁苷通过抑制内质网应激和微胶质活化发挥抗抑郁样作用：脂多糖诱导小鼠模型中的研究
Pei-Lu Chen,Guang-Hui Xu,Ming Li et al.
Pei-Lu Chen et al.
Depression is a multifaceted psychiatric disorder that affects a significant number of individuals worldwide, and its pathophysiology encompasses a variety of mechanisms, including the induction of endoplasmic reticulum (ER) stress, which h...
Ferroptosis-Regulated Cell Death as a Therapeutic Strategy for Neurodegenerative Diseases: Current Status and Future Prospects [0.03%]
铁沉积调节的细胞死亡在神经退行性疾病治疗中的研究现状与未来前景
Jia-Bao Zhang,Xiuqin Jia,Qi Cao et al.
Jia-Bao Zhang et al.
Ferroptosis is increasingly being recognized as a key element in the pathogenesis of diverse diseases. Recent studies have highlighted the intricate links between iron metabolism and neurodegenerative disorders. Emerging evidence suggests t...
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts [0.03%]
在生理pH条件下含有钠盐的α-突触核蛋白静息态自发聚集以二级过程为主导
Robert I Horne,Michael A Metrick nd,Wing Man et al.
Robert I Horne et al.
The accurate recapitulation in an in vitro assay of the aggregation process of α-synuclein in Parkinson's disease has been a significant challenge. As α-synuclein does not aggregate spontaneously in most currently used in vitro assays, pr...
Recent Advances in the Development of Near-Infrared Fluorescent Probes for the in Vivo Brain Imaging of Amyloid-β Species in Alzheimer's Disease [0.03%]
阿尔茨海默病近红外荧光探针检测活体脑内淀粉样蛋白的研究进展
Nilesh Gajanan Bajad,Ashok Kumar,Sushil Kumar Singh
Nilesh Gajanan Bajad
The deposition of β-amyloid (Aβ) plaques in the parenchymal and cortical regions of the brain of Alzheimer's disease (AD) patients is considered the foremost pathological hallmark of the disease. The early diagnosis of AD is paramount in ...
Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor [0.03%]
开发一种二氢喹啉-吡唑啉格鲁尼克C/2D选择性阴离子变构调节剂N-甲基天门冬氨酸受体的发展
Michael P D&#x;Erasmo,Nicholas S Akins,Peipei Ma et al.
Michael P D&#x;Erasmo et al.
Subunit-selective inhibition of N-methyl-d-aspartate receptors (NMDARs) is a promising therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer's and Parkinson's disease, depression, and acute brain injury. We ...
Implications of In Vitro Multi-Serine Phosphorylation of Alpha-Synuclein in Aggregation and Cytotoxicity [0.03%]
体外多丝氨酸磷酸化对α-突触核蛋白聚集和细胞毒性的潜在影响
Minal Chaturvedi,Ritu Raj,Sanjeev Kumar Yadav et al.
Minal Chaturvedi et al.
Post-translational modifications guide the functional diversity and identity of proteins. Phosphorylation is one such post-translational modification that has been reported in pathological proteins related to various neurodegenerative disor...
Neuroprotective Effect of Thiazolidine-2,4-dione Derivatives on Memory Deficits and Neuropathological Symptoms of Dementia on a Scopolamine-Induced Alzheimer's Model in Adult Male Wistar Rats [0.03%]
关于氯化斯克平致阿尔茨海默病模型大鼠记忆障碍及神经病理症状的硫唑烷二酮衍生物保护作用的研究
Maryam Taheri,Hossein Ghafoori,Hamid Sepehri et al.
Maryam Taheri et al.
Alzheimer's disease (AD) is a neurodegenerative disorder associated with a decline in memory deficits and neuropathological diagnosis with loss of cholinergic neurons in the brains of older adults. Based on these facts and an increasing num...
Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease [0.03%]
用于阿尔茨海默病治疗的乙酰胆碱酯酶(BChE)和组蛋白去乙酰化酶6(HDAC6)平衡双靶向抑制剂的设计、合成及概念验证研究
Lei Wang,Tianyu Sun,Zhenqi Wang et al.
Lei Wang et al.
Concomitant inhibition of butyrylcholinesterase (BChE) and histone deacetylase 6 (HDAC6) is supposed to be effective in the treatment of Alzheimer's disease (AD). Inspired by our previous efforts in designing BChE inhibitors, herein, select...
Oxidative Stress Occurs Prior to Amyloid Aβ Plaque Formation and Tau Phosphorylation in Alzheimer's Disease: Role of Glutathione and Metal Ions [0.03%]
氧化应激早于阿尔茨海默病淀粉样蛋白Aβ沉积和Tau蛋白磷酸化：谷胱甘肽及金属离子的作用
Rimil Guha Roy,Pravat K Mandal,Joseph C Maroon
Rimil Guha Roy
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that affects millions of people worldwide. Although the pathogenesis remains obscure, there are two dominant causal hypotheses. Since last three decades, am...
Telaprevir Improves Memory and Cognition in Mice Suffering Ischemic Stroke via Targeting MALT1-Mediated Calcium Overload and Necroptosis [0.03%]
泰拉普雷韦通过靶向MALT1介导的钙超载和坏死性凋亡改善缺血性卒中小鼠的记忆力和认知能力
Yi-Yue Zhang,Jing-Jie Peng,Di Chen et al.
Yi-Yue Zhang et al.
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) has been confirmed to contribute to brain injury in ischemic stroke via promoting excitotoxicity and necroptosis. Telaprevir, a hepatitis C virus protease inhibitor,...