Repurposing Antimicrobial Protegrin-1 as a Dual-Function Amyloid Inhibitor via Cross-seeding [0.03%]
通过交叉播种将抗菌肽蛋白酶格雷林-1重新定位为双功能淀粉样抑制剂
Yijing Tang,Dong Zhang,Jie Zheng
Yijing Tang
Amyloids and antimicrobial peptides have traditionally been recognized as distinct families with separate biological functions and targets. However, certain amyloids and antimicrobial peptides share structural and functional characteristics...
PET Evaluation of the Novel F-18 Labeled Reversible Radioligand [18F]GEH200449 for Detection of Monoamine Oxidase-B in the Non-Human Primate Brain [0.03%]
新型单胺氧化酶B检测剂[18F]GEH200449的非人灵长类脑PET成像研究
Katarina Varnäs,Sangram Nag,Christer Halldin et al.
Katarina Varnäs et al.
Positron emission tomography (PET) using radioligands for the enzyme monoamine oxidase B (MAO-B) is increasingly applied as a marker for astrogliosis in neurodegenerative disorders. In the present study, a novel reversible fluorine-18 label...
Deciphering the Inhibitory Mechanism of Naphthoquinone-Dopamine on the Aggregation of Tau Core Fragments PHF6* and PHF6 [0.03%]
萘醌衍生物NQ-DA抑制Tau核心片段PHF6和PHF6*聚集的分子机制解析
Yu Zou,Bote Qi,Jingwang Tan et al.
Yu Zou et al.
The formation of neurofibrillary tangles by abnormal aggregation of tau protein is considered to be an important pathological characteristic of tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. Two hexapeptide...
Modulating miR-146a Expression by Hydrogen Sulfide Ameliorates Motor Dysfunction and Axonal Demyelination in Cuprizone-Induced Multiple Sclerosis [0.03%]
通过调节miR-146a的表达改善氢硫化物引起的多发性硬化杯rizone诱导的运动功能障碍和轴突脱髓鞘
Heba R Ghaiad,Mai A Abd-Elmawla,Enas S Gad et al.
Heba R Ghaiad et al.
Multiple sclerosis (MS) is a progressive neuro-inflammatory and neuro-autoimmune disease. Although hydrogen sulfide has recently shown potential therapeutic impacts in different neurological diseases, its effects on MS are still obscure. Mi...
Corticosteroids as Selective and Effective Modulators of Glycine Receptors [0.03%]
皮质类固醇是甘氨酸受体的选择性有效调节剂
Elena I Solntseva,Julia V Bukanova,Rodion Kondratenko et al.
Elena I Solntseva et al.
The mechanism of the negative impact of corticosteroids on the induction and progress of mental illness remains unclear. In this work, we studied the effects of corticosteroids on the activity of neuronal glycine receptors (GlyR) and GABA-A...
Zein-Based Nanoparticles Improve the Therapeutic Efficacy of a TrkB Agonist toward Alzheimer's Disease [0.03%]
基于zeit的纳米粒子可改善trkb激动剂治疗阿尔茨海默病的效果研究
Guangxing Wang,Jianxin Han,Xin Meng et al.
Guangxing Wang et al.
The brain-derived neurotrophic factor (BDNF)/TrkB pathway plays a crucial role in neural plasticity and neuronal survival but is often deficient in neurodegenerative diseases like Alzheimer's disease (AD). CF3CN acts as a specific TrkB agon...
APPI-Derived Cyclic Peptide Enhances Aβ42 Aggregation and Reduces Aβ42-Mediated Membrane Destabilization and Cytotoxicity [0.03%]
APP衍生的环肽可增强Aβ42聚集并降低Aβ42介导的膜不稳定性及细胞毒性
Shiran Lacham-Hartman,Reut Moshe,Shani Ben-Zichri et al.
Shiran Lacham-Hartman et al.
An amyloid precursor protein inhibitor (APPI) and amyloid beta 42 (Aβ42) are both subdomains of the human transmembrane amyloid precursor protein (APP). In the brains of patients with Alzheimer's disease (AD), Aβ42 oligomerizes into aggre...
Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice [0.03%]
通过减少氧化应激和线粒体功能障碍对抗罗通宁诱导的帕金森病小鼠的人心叶藤神经保护作用
Hagera Dilnashin,Hareram Birla,Chetan Keswani et al.
Hagera Dilnashin et al.
Oxidative stress and mitochondrial dysfunction are leading mechanisms that play a crucial role in the progression of Parkinson's disease (PD). Tinospora cordifolia shows a wide range of biological activities including immunomodulatory, anti...
Yamogenin Exhibits Antidepressant-like Effects via Inhibition of ER Stress and Microglial Activation in LPS-Induced Mice [0.03%]
甜高梁苷通过抑制内质网应激和微胶质活化发挥抗抑郁样作用：脂多糖诱导小鼠模型中的研究
Pei-Lu Chen,Guang-Hui Xu,Ming Li et al.
Pei-Lu Chen et al.
Depression is a multifaceted psychiatric disorder that affects a significant number of individuals worldwide, and its pathophysiology encompasses a variety of mechanisms, including the induction of endoplasmic reticulum (ER) stress, which h...
Ferroptosis-Regulated Cell Death as a Therapeutic Strategy for Neurodegenerative Diseases: Current Status and Future Prospects [0.03%]
铁沉积调节的细胞死亡在神经退行性疾病治疗中的研究现状与未来前景
Jia-Bao Zhang,Xiuqin Jia,Qi Cao et al.
Jia-Bao Zhang et al.
Ferroptosis is increasingly being recognized as a key element in the pathogenesis of diverse diseases. Recent studies have highlighted the intricate links between iron metabolism and neurodegenerative disorders. Emerging evidence suggests t...