Neuralized1-Mediated CPEB3 Ubiquitination in the Spinal Dorsal Horn Contributes to the Pathogenesis of Neuropathic Pain in Rats [0.03%]
神经病理性疼痛模型大鼠脊髓背角CPEB3泛素化降解的机制研究
Jian Zhang,Xuan Zhang,Yan Gao et al.
Jian Zhang et al.
Compelling evidence has shown that Neuralized1 (Neurl1) facilitates hippocampal-dependent memory storage by modulating cytoplasmic polyadenylation element-binding protein 3 (CPEB3)-dependent protein synthesis. In the current study, we inves...
Insight into the Binding of First- and Second-Generation PET Tracers to 4R and 3R/4R Tau Protofibrils [0.03%]
第一代和第二代PET示踪剂与4R及3R/4RTau原纤维结合的机理研究
Junhao Li,Amit Kumar,Bengt Långström et al.
Junhao Li et al.
Primary supranuclear palsy (PSP) is a rare neurodegenerative disease that perturbs body movement, eye movement, and walking balance. Similar to Alzheimer's disease (AD), the abnormal aggregation of tau fibrils in the central neuronal and gl...
Synergistic Screening of Peptide-Based Biotechnological Drug Candidates for Neurodegenerative Diseases Using Yeast Display and Phage Display [0.03%]
利用酵母展示和噬菌体展示协同筛选神经退行性疾病肽类药物候选物
Cemile Elif Özçelik,Özge Beğli,Ahmet Hınçer et al.
Cemile Elif Özçelik et al.
Peptide therapeutics are robust and promising molecules for treating diverse disease conditions. These molecules can be developed from naturally occurring or mimicking native peptides, through rational design and peptide libraries. We devel...
Clinical Theragnostic Signature of Extracellular Vesicles in Traumatic Brain Injury (TBI) [0.03%]
创伤性脑损伤(TBI)的临床诊断标志物外泌体签名
Anuvab Dey,Subhrojyoti Ghosh,Tiyasa Bhuniya et al.
Anuvab Dey et al.
Traumatic brain injury (TBI) is a common cause of disability and fatality worldwide. Depending on the clinical presentation, it is a type of acquired brain damage that can be mild, moderate, or severe. The degree of patient's discomfort, pr...
Lei Ortigosa-Pascual,Thom Leiding,Sara Linse et al.
Lei Ortigosa-Pascual et al.
Photo-induced cross-linking of unmodified proteins (PICUP) has been used in the past to study size distributions of protein assemblies. PICUP may, for example, overcome the significant experimental challenges related to the transient nature...
Interplay of Metallome and Metabolome in Amyotrophic Lateral Sclerosis: A Study on Cerebrospinal Fluid of Patients Carrying Disease-Related Gene Mutations [0.03%]
遗传性肌萎缩侧索硬化症患者的脑脊液中金属元素与代谢物的互作研究
Nikolay Solovyev,Marianna Lucio,Jessica Mandrioli et al.
Nikolay Solovyev et al.
Amyotrophic lateral sclerosis (ALS) is a lethal progressive neurodegenerative disease, characterized by a loss of function of upper and lower motor neurons. This study aimed to explore probable pathological alterations occurring in individu...
The Amphiphilic Property and Structure of β-Amyloid Peptide Contribute to Its Impacts on the Activities of Horseradish Peroxidase and Alkaline Phosphatase [0.03%]
β-淀粉样蛋白的两亲性及构象变化对其影响辣根过氧化物酶和碱性磷酸酶活性的作用
Ling Mo,Jiang Chen,Chuanbin Cai et al.
Ling Mo et al.
Recent studies have found that β-amyloid (Aβ) oligomers may play much more important roles than amyloid plaques in the pathogenesis of Alzheimer's disease (AD). However, due to the complexity of Aβ, studying the structural basis of Aβ o...
Elucidation of Secondary Structure and Toxicity of α-Synuclein Oligomers and Fibrils Grown in the Presence of Phosphatidylcholine and Phosphatidylserine [0.03%]
磷脂酰胆碱和磷脂酰丝氨酸存在下α-突触核蛋白寡聚体和原纤维的二级结构及毒性研究
Tianyi Dou,Mikhail Matveyenka,Dmitry Kurouski
Tianyi Dou
Abrupt aggregation of α-synuclein (α-Syn) in the midbrain hypothalamus and thalamus is a hallmark of Parkinson's disease (PD), the fastest growing neurodegenerative pathology, projected to strike 12 million people by 2040 worldwide. In th...
Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke [0.03%]
DNP极化剂对生化过程的影响：一过性缺血性卒中中的TEMPOL效应
Thanh Phong Lê,Lara Buscemi,Mario Lepore et al.
Thanh Phong Lê et al.
Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously...
Epigallocatechin Gallate: A Multifaceted Molecule for Neurological Disorders and Neurotropic Viral Infections [0.03%]
EGCG：一种用于神经性疾病和嗜神经病毒感染的多功能分子
Annu Rani,Vaishali Saini,Priyanka Patra et al.
Annu Rani et al.
Epigallocatechin-3-gallate (EGCG), a polyphenolic moiety found in green tea extracts, exhibits pleiotropic bioactivities to combat many diseases including neurological ailments. These neurological diseases include Alzheimer's disease, multi...