Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer's in Rats: Insights into the Underlying Mechanisms [0.03%]
萨罗格列扎塔尔对山梗菜碱诱导的阿尔兹海默症大鼠的神经保护作用及潜在机制研究
Grandhi Sandeep Ganesh,Prasad Konduri,Aravinda Sai Kolusu et al.
Grandhi Sandeep Ganesh et al.
Alzheimer's disease (AD) is one of the most prevalent and progressive neurodegenerative disorders, hallmarked by increased amyloid-β deposition and enhanced oxidative load in the brain, ensuing cognitive decline. The present study is aimed...
Protein Drug Delivery Using a Novel Maxillofacial Technique Targeting the Visual Pathway in the Brain, the Optic Nerve, and the Retina [0.03%]
一种新颖的颌面技术用于蛋白质药物输送以靶向脑部视觉通路、视神经和视网膜
Rahini Rajendran,Jayamuruga Pandian Arunachalam,Subbulakshmi Chidambaram et al.
Rahini Rajendran et al.
Protein drugs are used for treating many diseases of the eye and the brain. The formidable blood neural barriers prevent the delivery of these drugs into the eye and the brain. Hence, there is a need for a protein drug delivery system to de...
Proteolytically Stable ααγ-Hybrid Peptides Inhibit the Aggregation and Cytotoxicity of Aβ42 [0.03%]
蛋白酶稳定型ααγ-嵌合肽抑制Aβ42聚集及其细胞毒性作用
DRGKoppalu R Puneeth Kumar,Sachin A Nalawade,Saikat Pahan et al.
DRGKoppalu R Puneeth Kumar et al.
The recent approval of antibody-based therapy for targeting the clearance of amyloid plaques fuels the research in designing small molecules and peptide inhibitors to target the aggregation of Aβ-peptides. Here, we report that the 15-resid...
DPP-4 Inhibitors Suppress Tau Phosphorylation and Promote Neuron Autophagy through the AMPK/mTOR Pathway to Ameliorate Cognitive Dysfunction in Diabetic Mellitus [0.03%]
DPP-4抑制剂通过AMPK/mTOR途径抑制tau蛋白磷酸化并促进神经元自噬从而改善糖尿病的认知功能障碍
Ying Hu,Jixiong Xu,Jiancheng Wang et al.
Ying Hu et al.
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been considered as incretin-based agents that signal through GLP-1R. Our high-throughput RNA sequencing (RNA-seq) and bioinformatics methods indicated that GLP-1R, downregulated in diabetes mel...
κ-Carrageenan Oligosaccharides Protect Nerves by Regulating Microglial Autophagy in Alzheimer's Disease [0.03%]
κ-卡拉胶寡糖通过调节小胶质细胞自噬保护阿尔茨海默病神经元
Haojian Sun,Ling Xu,Kangkang Wang et al.
Haojian Sun et al.
κ-Carrageenan is a linear sulfated polysaccharide extracted from the cell wall of marine red algae, and its enzymatically digested oligosaccharides (KOS) can inhibit microglial hyperactivation. Alzheimer's disease (AD) is a common chronic ...
Unveiling the Selectivity Mechanism of Type-I LRRK2 Inhibitors by Computational Methods: Insights from Binding Thermodynamics and Kinetics Simulation [0.03%]
基于计算方法揭示I型LRRK2抑制剂选择性作用机制：从结合热力学和动态模拟中获得的启示
Shuoyan Tan,Jun Wang,Peng Gao et al.
Shuoyan Tan et al.
Understanding the selectivity mechanisms of inhibitors toward highly similar proteins is very important in new drug discovery. Developing highly selective targeting of leucine-rich repeat kinase 2 (LRRK2) kinases for the treatment of Parkin...
Retinal Neurotransmitter Alteration in Response to Dopamine D2 Receptor Antagonist from Myopic Guinea Pigs [0.03%]
由近视豚鼠多巴胺D2受体拮抗剂诱导的视网膜神经递质变化
Pinghui Wei,Guoge Han,Meiqin He et al.
Pinghui Wei et al.
This study aimed to investigate the changes in retinal neurotransmitters and the role of the dopamine D2 receptor (D2R) pathway in regulating the myopic refractive state. Tricolor guinea pigs were randomly divided into two groups: the norma...
Apamin, an SK2 Inhibitor, Attenuated Neonatal Sevoflurane Exposures Caused Cognitive Deficits in Mice through the Regulation of Hippocampal Neuroinflammation [0.03%]
阿帕米因通过调节海马神经炎症而削弱了异氟醚暴露导致的认知缺陷
Heying Zhong,Xiaojuan Ran,Bin Chen et al.
Heying Zhong et al.
Cognitive dysfunction induced by anesthesia in the infant is a crucial clinical issue that is still being debated and the focus of concern for the parents. However, the mechanism of cognitive decline caused by anesthesia and the correspondi...
3D Printed Customizable Microsampling Devices for Neuroscience Applications [0.03%]
用于神经科学研究的可自定义微取样设备的3D打印技术
Patrick M Pysz,Julia K Hoskins,Min Zou et al.
Patrick M Pysz et al.
Multifunctional devices that incorporate chemical or physical measurements combined with ways to manipulate brain tissue via drug delivery, electrical stimulation, or light for optogenetics are desired by neuroscientists. The next generatio...
Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram [0.03%]
棕榈酰化调节五羟色胺转运蛋白活性、转录和表达并受艾斯西酞普兰调控
Christopher R Brown,James D Foster
Christopher R Brown
In the central nervous system, serotonergic signaling modulates sleep, mood, and cognitive control. During serotonergic transmission, the synaptic concentration of serotonin is tightly controlled in a spatial and temporal manner by the sero...