Adinazolam, a Benzodiazepine-Type New Psychoactive Substance, Has Abuse Potential and Induces Withdrawal Symptoms in Rodents [0.03%]
新型精神活性物质阿扎多泮具有滥用潜力并可诱导啮齿动物产生戒断症状
Su-Bin Hwang,Jae-Gyeong Lee,Youyoung Lee et al.
Su-Bin Hwang et al.
Adinazolam (ADZ) is a benzodiazepine-type new psychoactive substance (NPS) with anxiolytic, anticonvulsant, and antidepressant effects. High ADZ doses have been reported to impair psychomotor performance and memory; however, the abuse poten...
Elemental Mapping in a Preclinical Animal Model Reveals White Matter Copper Elevation in the Acute Phase of Central Nervous System Trauma [0.03%]
在中枢神经系统创伤急性期的前期动物模型中进行元素图谱绘制发现白质铜升高现象
Cameron W Evans,Abigail Egid,Somayra S A Mamsa et al.
Cameron W Evans et al.
Understanding the chemical events following trauma to the central nervous system could assist in identifying causative mechanisms and potential interventions to protect neural tissue. Here, we apply a partial optic nerve transection model o...
Transcription Factor GLI1 Induces IL-6-Mediated Inflammatory Response and Facilitates the Progression of Adamantinomatous Craniopharyngioma [0.03%]
转录因子GLI1通过诱导IL-6介导的炎症反应促进 adamantinomatous 型颅咽管瘤进展
Jingyi Zhao,Yongqiang Yang,Yuanyuan Pan et al.
Jingyi Zhao et al.
Adamantinomatous craniopharyngioma (ACP) is a neuroendocrine tumor whose pathogenesis remains unclear. This study investigated the role of glioma-associated oncogene family zinc finger 1 (GLI1), a transcription factor in the sonic hedgehog ...
Pathogenesis of Alzheimer's Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential [0.03%]
阿尔茨海默病的发病机制及1,2,3-三氮唑支架在药物研发中的多样性：设计策略、结构见解和治疗潜力
Atamjit Singh,Karanvir Singh,Jashandeep Kaur et al.
Atamjit Singh et al.
Alzheimer's disease is a most prevalent form of dementia all around the globe and currently poses a significant challenge to the healthcare system. Currently available drugs only slow the progression of this disease rather than provide prop...
Elucidation of the Role of Lipids in Late Endosomes on the Aggregation of Insulin [0.03%]
脂质在晚期内体中在胰岛素聚集中的作用的阐明
Ritu Joshi,Kiryl Zhaliazka,Aidan P Holman et al.
Ritu Joshi et al.
Abrupt aggregation of misfolded proteins is the underlying molecular cause of numerous pathologies including diabetes type 2 and injection amyloidosis. Although the exact cause of this process is unclear, a growing body of evidence suggests...
Ex Vivo Electrochemical Monitoring of Cholinergic Signaling in the Mouse Colon Using an Enzyme-Based Biosensor [0.03%]
基于酶的生物传感器在小鼠结肠中体外电化学监测胆碱能信号
Skye Henderson,Madison Strait,Roxanne Fernandes et al.
Skye Henderson et al.
Cholinergic signaling, i.e., neurotransmission mediated by acetylcholine, is involved in a host of physiological processes, including learning and memory. Cholinergic dysfunction is commonly associated with neurodegenerative diseases, inclu...
Mass Spectrometric Analysis of Urinary N-Glycosylation Changes in Patients with Parkinson's Disease [0.03%]
帕金森病患者尿液N-糖基化变化的质谱分析研究
Mingming Xu,Hong Jin,Wei Ge et al.
Mingming Xu et al.
Urine is thought to provide earlier and more sensitive molecular changes for biomarker discovery than blood. Numerous glycoproteins, peptides, and free glycans are present in urine through glomerular filtration of plasma, cell shedding, apo...
Rachel Wallace,David E Olson,Jacob M Hooker
Rachel Wallace
Neuroplasticity is a term that is increasingly permeating mainstream discourse and being used by the popular press to simplify descriptions of how the brain changes in response to stimuli such as exercise, sleep, food, drugs of abuse, and m...
Role of Saturation and Length of Fatty Acids of Phosphatidylserine in the Aggregation of Transthyretin [0.03%]
磷脂酰丝氨酸脂肪酸的饱和度及长度对甲状腺转运蛋白聚集的影响作用研究
Abid Ali,Kiryl Zhaliazka,Tianyi Dou et al.
Abid Ali et al.
The progressive accumulation of transthyretin (TTR), a small protein that transports thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a severe pathology that affects the central, peripheral, and autonomic...
Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target [0.03%]
孤儿G蛋白偶联受体GPR37成为治疗靶点的潜力
Andrew A Bolinger,Andrew Frazier,Jun-Ho La et al.
Andrew A Bolinger et al.
G protein-coupled receptors (GPCRs) are successful druggable targets, making up around 35% of all FDA-approved medications. However, a large number of receptors remain orphaned, with no known endogenous ligand, representing a challenging bu...