Tracking ClO- Dynamics during the Progression of Parkinson's Disease in MPTP Mouse Model Using In Vivo Brain Microdialysis [0.03%]
利用脑微透析技术追踪MPTP小鼠模型帕金森病发展过程中ClO-的动态变化规律
Yuqi Cheng,Cuicui Jiang,Zhenhui Zhang et al.
Yuqi Cheng et al.
Oxidative stress induced by hypochlorite (ClO-) is significant in Parkinson's disease (PD) pathogenesis, yet the dynamic variation in the brain's ClO- level during PD progression remains unclear. Herein, we developed a new reliable method c...
Stimulus-Driven Remodeling of Microglial Endocannabinoid Metabolism Illuminates ABHD12 Function in Immunity [0.03%]
刺激驱动的微胶质细胞内源大麻素代谢重塑揭示ABHD12在免疫中的功能
Noëlle van Egmond,Elisabeth A Jalink,Daan van der Vliet et al.
Noëlle van Egmond et al.
Microglia, the brain's macrophages, dynamically reprogram their metabolism to acquire appropriate and unique states to coordinate neuroinflammatory responses. Lipid metabolism, such as endocannabinoid signaling, is increasingly acknowledged...
In Vivo Time-Lapse Imaging Reveals Differential Activity-Induced Regulation of Proteasome Activity in Subcellular Regions of the Optic Tectum in Xenopus laevis Tadpoles [0.03%]
活体时间推移成像揭示斑皮蛙蝌蚪视顶盖亚细胞区室中的蛋白酶体活性的调节机制
Jessica M Lin,Benjamin Baah Konadu,Darci J Trader et al.
Jessica M Lin et al.
The proteasome is a major organelle responsible for protein degradation in neurons and has been implicated in the regulation of signal transduction and activity-dependent plasticity mechanisms that are essential for normal neuronal function...
Rational Design and Evaluation of Rivastigmine-Based Pleiotropic Prodrugs for the Treatment of Alzheimer's Disease [0.03%]
雷凡斯蒂吉明茋醇prodrug的设计与评估以治疗阿尔茨海默病
Valentin Travers-Lesage,Marc Since,Alice Wang et al.
Valentin Travers-Lesage et al.
The multifactorial origin of Alzheimer's disease (AD) is currently being addressed with the development of combination therapy or multitarget directed ligands. If the conventional approach of targeting acetylcholinesterase (AChE) for AD tre...
Clemizole Mitigates Traumatic Brain Injury by Inhibiting Oxidative Stress, Neuroinflammation, and Apoptosis [0.03%]
克利米唑通过抑制氧化应激、神经炎症和细胞凋亡来缓解创伤性脑损伤
Chandan Chauhan,Paarth Kumar,Harapriya Baral et al.
Chandan Chauhan et al.
Traumatic brain injury (TBI) triggers complex secondary pathological mechanisms, including neuroinflammation, oxidative stress, and apoptosis, contributing to long-term cognitive and motor deficits. This study investigates the neuroprotecti...
The N-Acylpolyamine Structure Assigned as Parawixin10 Does Not Display Positive Allosteric Modulatory Activity in EAAT1-3 Radioligand Uptake Assays, nor Does It Enhance Neuronal Survival in Mice in a Dose-Dependent and Statistically Significant Way [0.03%]
命名为Parawixin10的N-酰基多胺类化合物不具备EAAT1-3放射配体摄取试验中的正向变构调节活性，且不会以剂量依赖性和统计学显著性的方式增强小鼠神经元存活率
Yasaman Doroudian,Melissa Schepers,Tim Vanmierlo et al.
Yasaman Doroudian et al.
Enhancing glutamate (Glu) uptake by positive allosteric modulation of excitatory amino acid transporter subtype 2 (EAAT2) is an attractive strategy to enable neuroprotection. However, while the EAAT field is rich in reports on inhibitors, e...
Cannabidiol and pBDNF Cotreatment Attenuates Pathological Symptoms and Improves Cognition in 3 month-Old 5XFAD Mice [0.03%]
大麻二酚和pBDNF联合治疗可减轻5个月龄5XFAD小鼠的病理症状并改善其认知能力
Bivek Chaulagain,Avinash Gothwal,Arun Kumar Mahanta et al.
Bivek Chaulagain et al.
The marginal efficiency observed with the existing therapies in Alzheimer's Disease (AD) can be attributed to the timing of the treatment. The beneficiaries of symptomatic or disease-modifying therapy for AD are mild-cognitive-impairment (M...
Propionate Aggravates Anxiety and Cognitive Dysfunction in High-Fat Diet Mice by Activating Hippocampal Microglia-Mediated Neuroinflammation [0.03%]
丙酸通过激活海马小胶质细胞介导的神经炎症加重高脂饮食小鼠的焦虑和认知障碍
Xiang Zuo,Huijuan Bai,Qili Zhao et al.
Xiang Zuo et al.
Insulin resistance constitutes a major global public health burden, and obesity─a critical precursor of insulin resistance─is closely associated with comorbid anxiety, depressive disorders, and cognitive impairments. Propionate, a short-c...
Longitudinal PET Imaging of the Effects of a D2 Dopamine Receptor Antisense Oligonucleotide [0.03%]
D2多巴胺受体反义寡核苷酸的纵向PET imaging研究
Fatima Cheataini,Caroline Bouillot,Marco Valdebenito et al.
Fatima Cheataini et al.
While antisense oligonucleotide (ASOs) therapies have emerged as promising tools to modulate gene expression in neurological diseases, these new agents face challenges in the context of the central nervous system, particularly regarding dis...
Lei Ortigosa-Pascual,Noemi Ferrante Carrante,Katja Bernfur et al.
Lei Ortigosa-Pascual et al.
α-Synuclein (αSyn) is a neuronal protein predominantly found at the synapse, involved in vesicle trafficking. αSyn aggregates are also the main component of Lewy bodies, the hallmarks of Parkinson's disease. Interactions between the N- a...