New KV7.2/3 Channel Activators Exhibit Superior Toxicity and Metabolic Profiles to Flupirtine and Demonstrate Promising In Vivo Analgesic Effects [0.03%]
新型KV7通道激活剂的体内镇痛作用及优于氟吡汀的毒理学和代谢特征
Frieda-Marie Bartz,Kinga Sałat,Katarzyna Urbańska et al.
Frieda-Marie Bartz et al.
The first-in-class KV7.2/3 channel activator flupirtine, was considered a potent analgesic in various pain conditions. However, it was withdrawn from the market in 2018 due to severe hepatotoxicity associated with forming reactive metabolit...
Alzheimer's Disease: A Review of Molecular Mechanisms and Therapeutic Implications by Targeting Sirtuins, Caspases, and GSK-3 [0.03%]
阿尔茨海默病：通过靶向Sirtuins、半胱天冬酶和GSK-3作用分子机制及治疗意义的综述
Kalpana Pandya,Krishnashish Roul,Avanish Tripathi et al.
Kalpana Pandya et al.
Alzheimer's disease (AD) is a neurodegenerative disease with a significant impact on global public health. The primary hallmarks of the disease included amyloid-beta peptide (Aβ) deposition, neurofibrillary tangles (NFT), and synaptic loss...
An Integrative Analysis of Metagenomic and Metabolomic Profiling Reveals Gut Microbiome Dysbiosis and Metabolic Alterations in ALS: Potential Biomarkers and Therapeutic Insights [0.03%]
整合代谢组学和宏基因组分析发现ALS患者的肠道菌群失调及代谢改变：潜在生物标志物与治疗启示
Priyanka Gautam,Rahul Yadav,Ranjeet Kumar Vishwakarma et al.
Priyanka Gautam et al.
ALS is a severe neurodegenerative disorder characterized by motor neuron degeneration, gut dysbiosis, immune dysregulation, and metabolic disturbances. In this study, shotgun metagenomics and 1H nuclear magnetic resonance (NMR)-based metabo...
Electric Patch-Clamp Probing and Computational Studies of Lipid Bilayer Structural Fluctuations Induced by Methylamphetamine on a Neuronal Cell Membrane [0.03%]
甲基苯丙胺诱发神经元细胞膜双层结构波动的电patch clamp检测及计算研究
Hashini R Eheliyagoda,H Peter Lu
Hashini R Eheliyagoda
Investigating how the central nervous system stimulant methylamphetamine (METH) disrupts neuronal cell membranes is crucial, as lack of knowledge of the molecular-level disruptions-such as complex solvation dynamics and alterations in the l...
Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties [0.03%]
靶向与精神分裂症相关的GABA能低功能：α1β2γ2GABA-A受体配体的鉴定，该配体具有神经保护和抗精神病作用
Barbara Mordyl,Katarzyna Szafrańska,Joanna Sniecikowska et al.
Barbara Mordyl et al.
Clinical evidence has demonstrated significant hypofunction of GABAergic neurotransmission in patients with schizophrenia, likely contributing to the onset of psychotic symptoms. These symptoms can be alleviated by α1β2γ2GABA-A receptor ...
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives [0.03%]
经典致幻剂在镇痛调节中的作用：机制、临床证据和未来展望
Anna Czopek,Jakub Jończyk,Monika Fryc et al.
Anna Czopek et al.
Millions worldwide suffer from chronic pain, a complex condition often accompanied by depression and anxiety, highlighting the urgent need for innovative treatments. Classic psychedelics, including psilocybin, lysergic acid diethylamide (LS...
Tyrosine: A Key Neurotransmitter in Selective Serotonin Reuptake Inhibitor Treatment for Chronic Restraint Stress-Induced Reduction of Intestinal Innate Lymphoid Cell Type 3 Cells [0.03%]
酪氨酸：在选择性5-羟色胺再摄取抑制剂治疗慢性束缚应激诱导的肠固有类3淋巴样细胞减少中的关键神经递质作用
Yilin Wu,Chujun Duan,Niqi Shan et al.
Yilin Wu et al.
Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants. Given the prevalence of depression and its associated immune dysregulation, understanding the role of SSRIs in these processes is crucial. This study aims to e...
Myelin Sheaths as "Accessories in Clothing" for Individualizing Every Neuron [0.03%]
髓鞘作为为每个神经元“量身定制”的“配饰”
Alexander Shimkevich
Alexander Shimkevich
Here, the model of dissipative waveguide presents an axon where oscillations of ions generate electromagnetic waves that extend at the speed of light in a given medium. A transmission of spikes (wave packets) along axons is perfectly descri...
Correction to "Differential Effects of Aβ Peptides on the Plasmin-Dependent Degradation of ApoE3 and ApoE4" [0.03%]
关于"Aβ肽对ApoE3和ApoE4的 plamin依赖性降解的不同影响"一文的更正通知
Merc M Kemeh,Anthony J Furnelli,Noel D Lazo
Merc M Kemeh
Published Erratum
ACS chemical neuroscience. 2025 Jun 2. DOI:10.1021/acschemneuro.5c00324 2025
Cerdulatinib Improves Sensorimotor Function and Memory Ability in Mice Suffering from Ischemic Stroke through Targeting Caspase-3-Dependent Apoptosis [0.03%]
塞来妥利尼通过靶向半胱天冬酶-3依赖性凋亡改善缺血性卒鼠的躯体感觉和运动功能以及记忆力下降现象
Yi-Yue Zhang,Rui-Feng Li,Jing Tian et al.
Yi-Yue Zhang et al.
Caspase-3-dependent apoptosis is believed to contribute to the brain injury of ischemic stroke, and a caspase-3 inhibitor has been repeatedly reported to reduce the brain injury of ischemic stroke. However, currently recognized caspase-3 in...