Identification of a Nonelectrophilic and Selective TRPA1 Agonist for Alleviation of Inflammatory Pain through Channel Desensitization [0.03%]
一种非亲电子的、选择性的TRPA1激动剂通过通道脱敏作用来缓解炎症性疼痛的鉴定
Chaoyue Sun,Nan Yang,Ting Xin et al.
Chaoyue Sun et al.
Transient receptor potential ankyrin 1 (TRPA1) agonists exert long-lasting analgesic effects by inducing neuronal desensitization, a similar strategy has been confirmed in the approval of capsaicin, a transient receptor potential vanilloid ...
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson's Disease Protein Alpha-Synuclein [0.03%]
SARS-CoV-2刺突蛋白的一个淀粉样片段可刺激帕金森病蛋白α-突触核蛋白的聚集和毒性
João Flavio Gemignani,Paulo Augusto Netz,Daniel Izecksohn et al.
João Flavio Gemignani et al.
Emerging evidence suggests that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have long-term deleterious effects on the central nervous system and even contribute to post-COVID neurological syndromes. Intere...
Correction to "Crafting Precision: Design and Fabrication of Xurography-Driven Microfluidic Platform for Exploring Neuron Culture and Targeted Drug Screening" [0.03%]
关于“精密制作：设计和制造用于探索神经细胞培养和靶向药物筛选的Xurography驱动微流控平台”的勘误通知书
Subhadra Nandi,Arijit Bera,Satyajit Ghosh et al.
Subhadra Nandi et al.
Published Erratum
ACS chemical neuroscience. 2025 Aug 21. DOI:10.1021/acschemneuro.5c00630 2025
Detection of Neuronal Glutamate in Brain Extracellular Space In Vivo Using Microdialysis and Metabolic Labeling with Glutamine [0.03%]
采用微透析和谷氨酰胺代谢标记法检测脑内体液中的神经元谷氨酸
Neil D Hershey,Pavlo Popov,Nick Oliver et al.
Neil D Hershey et al.
Extracellular glutamate (Glu) concentration measured in the brain using microdialysis sampling is regulated differently from that expected for classical neurotransmitters; e.g., the basal Glu concentration is not affected by blocking action...
Hydrogen Sulfide-Releasing Insulin Polypeptide Mitigates Hyperglycemia-Induced Neurotoxicity and Cognitive Deficits In Vivo [0.03%]
体内氢 sulfide-释放型胰岛素多肽可减轻高血糖引起的神经毒性及认知缺陷
Rafat Ali,Shantanu Sen,Rohil Hameed et al.
Rafat Ali et al.
Hyperglycemia, a characteristic of diabetes, is increasingly associated with an elevated risk of neurodegenerative disorders, such as Parkinson's disease. Hyperglycemia serves as a comorbidity and hastens neurodegenerative processes in Park...
Evaluation of [18F]F-CNBI and [18F]F-CNPI PET Probes in GSK-3β Transgenic Mice [0.03%]
评估GSK-3β转基因小鼠中[18F]F-CNBI和[18F]F-CNPI PET探针的效果
Manasa Kethamreddy,Surendra Reddy Gundam,Andy Gonzalez Rivera et al.
Manasa Kethamreddy et al.
The present study explores the noninvasive positron emission tomography (PET) imaging for the detection of GSK-3β overexpression using [18F]F-CNPI and [18F]F-CNBI in a GSK-3β overexpressing transgenic mouse model. Herein, we validated GSK...
Novel Copper Chelators Enhance Spatial Memory and Biochemical Outcomes in Alzheimer's Disease Model [0.03%]
新的铜螯合剂可改善阿尔茨海默病模型小鼠空间记忆及生化指标
Mariana L M Camargo,Augusto B Farias,Giovana B Bertazzo et al.
Mariana L M Camargo et al.
This study explores the potential of novel molecules that can act as copper chelators to treat Alzheimer's disease. Eight imines L03-10 and one quinoline-based compound L11 were synthesized, characterized, and evaluated as compounds that ca...
Pharmacological Evaluation of Tropane Analogues at the Serotonin Transporter [0.03%]
用于五羟色胺再摄取蛋白的托烷类似物药理学研究
Arabo A Avanes,Hunter T Warren,Abinaya Senthil et al.
Arabo A Avanes et al.
Tropane alkaloids and their derivatives represent a diverse class of small molecules with a broad range of therapeutic applications. Many tropanes regulate synaptic levels of neuromodulators by interacting with monoamine transporters such a...
Fiber Photometry Analysis of Spontaneous Dopamine Signals: The Z-Scored Data Are Not the Data [0.03%]
光纤光度计分析自发性多巴胺信号：Z分数数据并非原始数据
Conner W Wallace,Emily K DiMarco,Clare Y Slinkard et al.
Conner W Wallace et al.
Fluorescent sensors have revolutionized the measurement of molecules in the brain, and the dLight dopamine sensor has been used extensively to examine reward- and cue-evoked dopamine release, but only recently has the field turned its atten...
Uncovering a Mutation-Independent Therapeutic Strategy against Inherited Retinal Diseases: Development of Class I HDAC/LSD1 Hybrid Inhibitors [0.03%]
揭示针对遗传性视网膜疾病的非突变依赖型治疗策略：I类HDAC/LSD1杂合抑制剂的开发
Gabriele Carullo,Ilaria Piano,Giulia Salamone et al.
Gabriele Carullo et al.
Among genetic retinal disorders, retinitis pigmentosa (RP) is characterized by degeneration of rod photoreceptors caused by a large number of diverse mutations, most of which act through different pathways to which epigenetic targets also c...