Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures [0.03%]
新型激动剂CMC23刺激形式肽受体-2保护内毒素诱导的神经炎症反应：器官型海马培养模型研究
Kinga Tylek,Ewa Trojan,Monika Leśkiewicz et al.
Kinga Tylek et al.
A substantial body of evidence demonstrates an association between a malfunction in the resolution of acute inflammation and the development of chronic inflammation. Recently, in this context, the importance of formyl peptide receptor 2 (FP...
Increased Gal-3 Mediates Microglia Activation and Neuroinflammation via the TREM2 Signaling Pathway in Prion Infection [0.03%]
Gal-3通过TREM2信号通路介导小胶质细胞激活和神经炎症以应对朊病毒感染
Qin Fan,Yue-Zhang Wu,Xiao-Xi Jia et al.
Qin Fan et al.
Galectin 3 (Gal-3) is one of the major elements for activating microglia and mediating neuroinflammation in some types of neurodegenerative diseases. However, its role in the pathogenesis of prion disease is seldom addressed. In this study,...
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke [0.03%]
FDCA减轻脑缺血后的神经炎症和脑损伤
Xin Guan,Dasha Wei,Zhuangzhuang Liang et al.
Xin Guan et al.
Ischemic stroke is a deleterious cerebrovascular disease with few therapeutic options, and its functional recovery is highly associated with the integrity of the blood-brain barrier and neuroinflammation. The Rho-associated coiled-coil cont...
Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [18F]FE-PE2I-OH for Translational Dopamine Transporter Imaging [0.03%]
一种用于制备正电子发射断层扫描放射配体代谢物[18F]FE-PE2I-OH的体外代谢法：用于翻译型多巴胺转运体成像的一种便捷方法
Magnus Schou,Nahid Amini,Akihiro Takano et al.
Magnus Schou et al.
Undesired radiometabolites can be detrimental to the development of positron emission tomography (PET) radioligands. Methods for quantifying radioligand metabolites in brain tissue include ex vivo studies in small animals or labeling and im...
James W Checco
James W Checco
Endogenous peptides, such as neuropeptides and peptide hormones, play important roles in intercellular communication, can provide information on physiology, and are potential sources of biomarkers. Mass spectrometry-based peptidomics method...
Concise and Scalable Radiosynthesis of (+)-[18F]MDL100907 as a Serotonin 5-HT2A Receptor Antagonist for PET [0.03%]
简洁可放大的合成方法制备5-羟色胺5-HT2A受体放射配基正电子发射断层扫描(PET)显影剂[18F]MDL100907游离碱
Lahu N Chavan,Ronald Voll,Mar M Sanchez et al.
Lahu N Chavan et al.
5-Hydroxytryptamine (5-HT2A) receptors play an important role in several psychiatric disorders. In order to investigate the serotonin (5-HT) receptor in vivo, reliable syntheses are required for positron emission tomography (PET) 5-HT radio...
Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes [0.03%]
σ1受体敲除小鼠对疼痛相关抑郁的抵抗与疼痛引起的与情绪相关的基因改变逆转有关
Beatriz de la Puente,Daniel Zamanillo,Luz Romero et al.
Beatriz de la Puente et al.
Mice lacking the σ1 receptor chaperone (σ1R-/-) are resilient to depressive-like behaviors secondary to neuropathic pain. Examining the resilience's brain mechanisms could help develop conceptually novel therapeutic strategies. We explore...
Computational Modeling as a Tool to Drive the Development of a Novel, Chemical Device for Monitoring the Injured Brain and Body [0.03%]
计算模型在开发监测受损脑和体的新型化学设备中的应用
De-Shaine Murray,Laure Stickel,Martyn Boutelle
De-Shaine Murray
Real-time measurement of dynamic changes, occurring in the brain and other parts of the body, is useful for the detection and tracked progression of disease and injury. Chemical monitoring of such phenomena exists but is not commonplace, du...
Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model [0.03%]
基于虚拟筛选的磷二酯酶9抑制剂发现及其体外研究神经保护作用
Elisa Landucci,Giovanni Ribaudo,Margrate Anyanwu et al.
Elisa Landucci et al.
In the central nervous system, some specific phosphodiesterase (PDE) isoforms modulate pathways involved in neuronal plasticity. Accumulating evidence suggests that PDE9 may be a promising therapeutic target for neurodegenerative diseases. ...
Preliminary PET Imaging of Microtubule-Based PET Radioligand [11C]MPC-6827 in a Nonhuman Primate Model of Alzheimer's Disease [0.03%]
正电子发射断层扫描示踪剂[11C]MPC-6827在非人灵长类阿尔茨海默病模型中的初步成像研究
Bhuvanachandra Bhoopal,Krishna Kumar Gollapelli,Naresh Damuka et al.
Bhuvanachandra Bhoopal et al.
The microtubule (MT) instability observed in Alzheimer's disease (AD) is commonly attributed to hyperphosphorylation of the MT-associated protein, tau. In vivo PET imaging offers an opportunity to gain critical information about MT changes ...