Role of Bmal1 and Gut Microbiota in Alzheimer's Disease and Parkinson's Disease Pathophysiology: The Probable Effect of Melatonin on Their Association [0.03%]
BMAL1和肠道微生物群在阿尔茨海默病和帕金森病病理生理中的作用：褪黑素对其关联的可能影响
Mohammad Rafi Khezri,Ayda Esmaeili,Morteza Ghasemnejad-Berenji
Mohammad Rafi Khezri
In recent years, the role of new factors in the pathophysiology of neurodegenerative diseases has been investigated. Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases worldwide. Although pa...
Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation [0.03%]
评估N和O连接的吲哚三嗪对α-突触核蛋白和tau聚集的双重作用
Eduardo Ramirez,Susantha K Ganegamage,Sehong Min et al.
Eduardo Ramirez et al.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder underlying dementia in the geriatric population. AD manifests by two pathological hallmarks: extracellular amyloid-β (Aβ) peptide-containing senile plaques and intr...
Thymoquinone Alleviates Paclitaxel-Induced Peripheral Neuropathy through Regulation of the TLR4-MyD88 Inflammatory Pathway [0.03%]
通过调节TLR4-MyD88炎症途径硫磺酮缓解紫杉醇诱导的外周神经病变
Haizhu Xing,Shubo Zhang,Min You et al.
Haizhu Xing et al.
Paclitaxel-induced peripheral neuropathy (PIPN) is one of the common adverse effects during the paclitaxel (PTX) treatment of cancer. In this study, we investigated the neuroprotective effects and mechanisms of thymoquinone (TQ) in the PIPN...
Brain Virome in Neurodegenerative Disorders: Insights from Transcriptomic Data Analysis [0.03%]
transcriptomic数据研究神经系统退行性疾病中的脑病毒景观
Brinda Balakrishnan,Siva Santhiya Arul,Aarti Ravindran et al.
Brinda Balakrishnan et al.
Neurodegenerative disorders (NDs) are chronic ailments of the central nervous system that gradually deteriorate the structures and functions of neurons. The etiologies of NDs include genetic factors, aging, infections, starvation, brain tra...
Interplay of Cholesterol and Actin in Neurotransmitter GPCR Signaling: Insights from Chronic Cholesterol Depletion Using Statin [0.03%]
胆固醇和肌动蛋白在神经递质G蛋白偶联受体信号转导中的相互作用：源自他汀类药物慢性脱胆固醇研究的见解
Parijat Sarkar,Amitabha Chattopadhyay
Parijat Sarkar
Serotonin1A receptors are important neurotransmitter receptors in the G protein-coupled receptor (GPCR) family and modulate a variety of neurological, behavioral, and cognitive functions. We recently showed that chronic cholesterol depletio...
Potential of ADAM 17 Signal Peptide To Form Amyloid Aggregates in Vitro [0.03%]
ADAM 17信号肽的体外淀粉样蛋白聚集潜力
Taniya Bhardwaj,Rajanish Giri
Taniya Bhardwaj
ADAM 17, a disintegrin and metalloproteinase 17 belonging to the adamalysin protein family, is a Zn2+-dependent type-I transmembrane α-secretase protein. As a major sheddase, ADAM 17 acts as an indispensable regulator of chief cellular eve...
Intermediate Antiparallel β Structure in Amyloid β Plaques Revealed by Infrared Spectroscopic Imaging [0.03%]
红外光谱成像揭示淀粉样蛋白斑块中的中间态反平行β结构
Brooke Holcombe,Abigail Foes,Siddhartha Banerjee et al.
Brooke Holcombe et al.
Aggregation of amyloid β (Aβ) peptides into extracellular plaques is a hallmark of the molecular pathology of Alzheimer's disease (AD). Amyloid aggregates have been extensively studied in vitro, and it is well-known that mature amyloid fi...
Quantitative and Qualitative Analysis of Neurotransmitter and Neurosteroid Production in Cerebral Organoids during Differentiation [0.03%]
大脑类器官在分化过程中神经递质和神经甾体产生的定性和定量分析
Sung Bum Park,Byumseok Koh,Hyun Soo Kwon et al.
Sung Bum Park et al.
In the human brain, neurophysiological activity is modulated by the movement of neurotransmitters and neurosteroids. To date, the similarity between cerebral organoids and actual human brains has been evaluated using comprehensive multiomic...
Bridging the Binding Sites 2.0: Photoswitchable Dualsteric Ligands for the Cannabinoid 2 Receptor [0.03%]
桥联的结合位点2.0版：大麻素受体II型受体光控双结构配体
Sophie A M Steinmüller,Anna Tutov,James N Hislop et al.
Sophie A M Steinmüller et al.
The cannabinoid receptor 2 (CB2R) has high, unexploited therapeutic potential in several central nervous system disorders due to its involvement in neuroinflammatory processes and pathologies like neurodegeneration. Dualsteric/bitopic ligan...
Evaluation of [18F]RoSMA-18-d6 as a CB2 PET Radioligand in Nonhuman Primates [0.03%]
评估[18F]RoSMA-18-d6作为CB2 PET放射配体在非人灵长类动物中的应用
Ahmed Haider,Lu Wang,Luca Gobbi et al.
Ahmed Haider et al.
The cannabinoid type 2 receptor (CB2) has been implicated in a variety of central and peripheral inflammatory diseases, prompting significant interest in the development of CB2-targeted diagnostic and therapeutic agents. A validated positro...