Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System [0.03%]
定量分析多发性硬化症中枢神经系统中S1PR1的表达
Hao Jiang,Charles Zhou,Lin Qiu et al.
Hao Jiang et al.
Multiple sclerosis (MS) is an immune-mediated disease that is characterized by demyelination and inflammation in the central nervous system (CNS). Previous studies demonstrated that sphingosine-1-phosphate receptor (S1PR) modulators effecti...
Effects of Anesthetic Administration on Rat Hypothalamus and Cerebral Cortex Peptidome [0.03%]
麻醉药对大鼠下丘脑和大脑皮层肽组的影响
Somayeh Mousavi,Haowen Qiu,Frazer I Heinis et al.
Somayeh Mousavi et al.
Prohormone-derived neuropeptides act as cell-cell signaling molecules to mediate a wide variety of biological processes in the animal brain. Mass spectrometry-based peptidomic experiments are valuable approaches to gain insight into the dyn...
Pravat K Mandal,Joseph C Maroon,Arun Garg et al.
Pravat K Mandal et al.
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects millions of people worldwide. The characteristic pathological manifestation of AD includes the deposition of extracellular insoluble β amyloid plaques and in...
Exploring Multitarget Strategies for Membrane Protection in Alzheimer's Disease [0.03%]
阿尔茨海默病多靶点膜保护策略研究
Pablo Zambrano
Pablo Zambrano
The exploration of multitarget molecules presents a promising avenue in the quest for effective therapeutic strategies against Alzheimer's disease (AD), a multifactorial neurodegenerative disorder. Traditional single-target drugs have shown...
Oligomeric and Fibrillar α-Synuclein Display Persistent Dynamics and Compressibility under Controlled Confinement [0.03%]
寡聚和纤维状α-突触核蛋白在受控限制下的动力学与可压缩性研究
Katie Lynn Whitcomb,Kurt Warncke
Katie Lynn Whitcomb
The roles of α-synuclein in neurotransmitter release in brain neurons and in the Parkinson's disease condition have challenged comprehensive description. To gain insight into molecular mechanistic properties that actuate α-synuclein funct...
Leslie A Sombers
Leslie A Sombers
Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor [0.03%]
合成大麻素受体激动剂的细微结构修饰可显著增强其对CB1受体的作用效力
Hideaki Yano,Rezvan Chitsazi,Christopher Lucaj et al.
Hideaki Yano et al.
The emergence of synthetic cannabinoid receptor agonists (SCRAs) as illicit psychoactive substances has posed considerable public health risks, including fatalities. Many SCRAs exhibit much higher efficacy and potency compared with the phyt...
αS1-Casein-Loaded Proteo-liposomes as Potential Inhibitors in Amyloid Fibrillogenesis: In Vivo Effects on a C. elegans Model of Alzheimer's Disease [0.03%]
负载αS1-酪蛋白的蛋白质脂质体作为抑制淀粉样纤维形成的潜在抑制剂：阿尔茨海默病线虫模型中的体内效应
Angela Paterna,Pamela Santonicola,Giulia Di Prima et al.
Angela Paterna et al.
According to the amyloid hypothesis, in the early phases of Alzheimer's disease (AD), small soluble prefibrillar aggregates of the amyloid β-peptide (Aβ) interact with neuronal membranes, causing neural impairment. Such highly reactive an...
Identification of Aggregation Mechanism of Acetylated PHF6* and PHF6 Tau Peptides Based on Molecular Dynamics Simulations and Markov State Modeling [0.03%]
基于分子动力学模拟和马尔可夫状态模型的乙酰化PHF6*和PHF6Tau肽聚集机制识别
Syed Jawad Ali Shah,Qianqian Zhang,Jingjing Guo et al.
Syed Jawad Ali Shah et al.
The microtubule-associated protein tau (MAPT) has a critical role in the development and preservation of the nervous system. However, tau's dysfunction and accumulation in the human brain can lead to several neurodegenerative diseases, such...
Discovery of Potent and Selective CB2 Agonists Utilizing a Function-Based Computational Screening Protocol [0.03%]
基于功能的计算筛选获得 potent 和 selective 的CB2受体激动剂
Haixia Ge,Beihong Ji,Jiahui Fang et al.
Haixia Ge et al.
Nowadays, the identification of agonists and antagonists represents a great challenge in computer-aided drug design. In this work, we developed a computational protocol enabling us to design/screen novel chemicals that are likely to serve a...