Multi-Photon-Sensitive Chromophore for the Photorelease of Biologically Active Phenols [0.03%]
用于生物活性酚类物质光控释放的多光子敏化发色团
Naeem Asad,Davide Deodato,Nadeem Asad et al.
Naeem Asad et al.
Phenols confer bioactivity to a plethora of organic compounds. Protecting the phenolic functionality with photoremovable protecting groups (PPGs) sensitive to two-photon excitation (2PE) can block the bioactivity and provide controlled rele...
Effect of Terahertz Waves on the Structure of the Aβ42 Monomer, Dimer, and Protofibril: Insights from Molecular Dynamics Simulations [0.03%]
太赫兹波对Aβ42单体、二聚体和原纤维结构的影响：从分子动力学模拟中得到的见解
Chen Chen,Zeng-Shuai Yan,Yu-Qiang Ma et al.
Chen Chen et al.
Amyloid-β (Aβ) and its assemblies play important roles in the pathogenesis of Alzheimer's disease (AD). Recent studies conducted by experimental and computational researchers have extensively explored the structure, assembly, and influenc...
Natural Terpenes Inhibit the Cytopathogenicity of Naegleria fowleri Causing Primary Amoebic Meningoencephalitis in the Human Cell Line Model [0.03%]
天然倍半萜烯抑制原发性阿米巴脑膜脑炎病原Naegleria fowleri的细胞病变作用：人类细胞系模型研究
Kavitha Rajendran,Usman Ahmed,Alexia Chloe Meunier et al.
Kavitha Rajendran et al.
Naegleria fowleri is one of the free-living amoebae and is a causative agent of a lethal and rare central nervous system infection called primary amoebic meningoencephalitis. Despite the advancement in antimicrobial chemotherapy, the fatali...
Melatonin Relieves Paclitaxel-Induced Neuropathic Pain by Regulating pNEK2-Dependent Epigenetic Pathways in DRG Neurons [0.03%]
褪黑素通过调节DRG神经元中pNEK2依赖的表观遗传途径缓解紫杉醇诱导的神经病理性疼痛
Ming-Chun Hsieh,Cheng-Yuan Lai,Li-Ting Lin et al.
Ming-Chun Hsieh et al.
The neurohormone melatonin (MLT) demonstrates promising potential in ameliorating neuropathic pain induced by paclitaxel (PTX) chemotherapy. However, little is known about its protective effect on dorsal root ganglion (DRG) neurons in neuro...
Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[ b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity [0.03%]
小分子N-苯基苯并呋喃-2-甲酰胺和N-苯基苯并噻吩-2-甲酰胺促进β淀粉样蛋白(Aβ42)聚集及降低神经毒性
Yusheng Zhao,Praveen P N Rao
Yusheng Zhao
This study reports the unusual ability of small molecules N-phenylbenzofuran-2-carboxamide (7a) and N-phenylbenzo[b]thiophene-2-carboxamide (7b) to promote and accelerate Aβ42 aggregation. In the in vitro aggregation kinetic assays, 7a was...
Cyclization of Peptides Enhances the Inhibitory Activity against Ganglioside-Induced Aβ Fibril Formation [0.03%]
肽环化增强对神经节苷脂诱导的Aβ纤维形成的抑制作用
Erika Miyamoto,Toshinori Sato,Teruhiko Matsubara
Erika Miyamoto
Alzheimer's disease is a progressive neurodegenerative disease and is the most common cause of dementia. It has been reported that the assembly of amyloid β-protein (Aβ) on the cell membrane is induced by the interaction of the Aβ monome...
Expectancy Effects Cannot Be Neglected in MDMA-Assisted Therapy Research [0.03%]
马卡贝助疗研究中期待效应的影响不容忽视
L Jacob Flameling,Jacob S Aday,Michiel van Elk
L Jacob Flameling
Fingerprint of Circulating Immunocytes as Biomarkers for the Prognosis of Brain Inflammation and Neuronal Injury after Cardiac Arrest [0.03%]
心肺复苏后脑炎和神经元损伤的循环免疫细胞指纹生物标志物研究
Huanyu Dou,Nicole R Brandon,Kerryann E Koper et al.
Huanyu Dou et al.
Cardiac arrest is one of the most dangerous health problems in the world. Outcome prognosis is largely based on cerebral performance categories determined by neurological evaluations. Few systemic tests are currently available to predict su...
Classics in Chemical Neuroscience: Selegiline, Isocarboxazid, Phenelzine, and Tranylcypromine [0.03%]
化学神经科学经典系列——选择性单胺氧化酶抑制剂药物研究
Gavin R Hoffman,Madeline G Olson,Allen M Schoffstall et al.
Gavin R Hoffman et al.
The discovery of monoamine oxidase inhibitors (MAOIs) in the 1950s marked a significant breakthrough in medicine, creating a powerful new category of drug: the antidepressant. In the years and decades that followed, MAOIs have been used in ...
Wiring and Volume Transmission: An Overview of the Dual Modality for Serotonin Neurotransmission [0.03%]
serotonina神经传递的双通路模式：结构与功能概述
Giulia Gianni,Massimo Pasqualetti
Giulia Gianni
Serotonin is a neurotransmitter involved in the modulation of a multitude of physiological and behavioral processes. In spite of the relatively reduced number of serotonin-producing neurons present in the mammalian CNS, a complex long-range...