Jinming Wu,Xue Wang,Asvin Lakkaraju et al.
Jinming Wu et al.
Prion diseases are fatal neurodegenerative disorders characterized by the conversion of the cellular prion protein (PrPC) into a misfolded prion form, which is believed to disrupt the cellular membranes. However, the exact mechanisms underl...
Probing Chemical Complexity of Amyloid Plaques in Alzheimer's Disease Mice using Hyperspectral Raman Imaging [0.03%]
利用超光谱拉曼成像技术研究阿尔茨海默病小鼠淀粉样斑块的化学复杂性
Dušan Mrđenović,Benjamin F Combes,Ruiqing Ni et al.
Dušan Mrđenović et al.
One of the distinctive pathological features of Alzheimer's disease (AD) is the deposition of amyloid plaques within the brain of affected individuals. These plaques have traditionally been investigated using labeling techniques such as imm...
Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo [0.03%]
N端标记方法的应用为活体内普里昂蛋白内肽酶提供新的见解
Erik Gomez-Cardona,Ghazaleh Eskandari-Sedighi,Richard Fahlman et al.
Erik Gomez-Cardona et al.
Alternative α- and β-cleavage events in the cellular prion protein (PrPC) central region generate fragments with distinct biochemical features that affect prion disease pathogenesis, but the assignment of precise cleavage positions has pr...
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement [0.03%]
衰老标志及其与年龄相关疾病进展的关系：对研究进展的概览性分析
Rumiana Tenchov,Janet M Sasso,Xinmei Wang et al.
Rumiana Tenchov et al.
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susce...
Design, Synthesis, and Structure-Activity Relationship Studies of Novel GPR88 Agonists (4-Substituted-phenyl)acetamides Based on the Reversed Amide Scaffold [0.03%]
基于反式酰胺支架的新型GPR88激动剂(4-取代苯基)乙酰胺的设计、合成及构效关系研究
Md Toufiqur Rahman,Dongliang Guan,Hetti Handi Chaminda Lakmal et al.
Md Toufiqur Rahman et al.
The development of synthetic agonists for the orphan receptor GPR88 has recently attracted significant interest, given the promise of GPR88 as a novel drug target for psychiatric and neurodegenerative disorders. Examination of structure-act...
Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons [0.03%]
一种小分子自噬溶酶体途径调节剂的发现：该调节剂以核纤层A/C和灯丝蛋白1为靶点，可诱导自噬流并影响神经元中的溶酶体定位
Ryan S Hippman,Amanda M Snead,Zoe A Petros et al.
Ryan S Hippman et al.
Autophagy is a major catabolic degradation and recycling process that maintains homeostasis in cells and is especially important in postmitotic neurons. We implemented a high-content phenotypic assay to discover small molecules that promote...
Repurposing of the PET Probe Prototype PiB for Label and Radiation-Free CEST MRI Molecular Imaging of Amyloid [0.03%]
一种用于无放射性标记和辐射的CEST磁共振分子成像的示踪剂PiB探针的新用途原型研究
Caiyu Zhuang,Beibei Chen,Shuohua Wu et al.
Caiyu Zhuang et al.
Positron emission tomography (PET) probes are specific and sensitive while suffering from radiation risk. It is worthwhile to explore the chemical emission saturation transfer (CEST) effects of the probe prototypes and repurpose them for CE...
Characterization of (R)- and (S)-[18F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing N-Methyl-d-Aspartate Receptors [0.03%]
(R)-和(S)-[18F]OF-NB1在啮齿动物中作为正电子发射断层成像探针用于GluN2B亚基含N-甲基-D-天冬氨酸受体的影像学表征
Hazem Ahmed,Rahel Wallimann,Livio Gisler et al.
Hazem Ahmed et al.
The N-methyl-d-aspartate receptor (NMDAR) subtype 2B (GluN1/2B) is implicated in various neuropathologies. Given the lack of a validated radiofluorinated positron emission tomography (PET) probe for the imaging of GluN1/2B receptors, we com...
Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation [0.03%]
与Tau蛋白疾病相关的突变编码聚合体结构构象的变化
Kerry T Sun,Tark Patel,Sang-Gyun Kang et al.
Kerry T Sun et al.
The accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. Cryo-EM studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, suc...
Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism [0.03%]
α-Connoratoxine LvIA 的第 11 位碱基氨基酸通过静电机制影响 α3β2 和 α3β4 烟碱型受体的亚型选择性
Yves Haufe,Veeresh Kuruva,Ziyana Samanani et al.
Yves Haufe et al.
Understanding the determinants of α-conotoxin (α-CTX) selectivity for different nicotinic acetylcholine receptor (nAChR) subtypes is a prerequisite for the design of tool compounds to study nAChRs. However, selectivity optimization of the...