Long-Chain Polyunsaturated Fatty Acids Accelerate the Rate of Insulin Aggregation and Enhance Toxicity of Insulin Aggregates [0.03%]
长链多不饱和脂肪酸加速胰岛素聚合的速率并增强胰岛素聚集体的毒性
Zachary Hoover,Michael Lynn,Kiryl Zhaliazka et al.
Zachary Hoover et al.
Long-chain polyunsaturated fatty acids (LCPUFAs) are essential components of a human diet. These molecules are critically important for cognitive attention and memory, mood states, coronary circulation, and cirrhosis. However, recently repo...
Role of NLRP3 Inflammasome in Stroke Pathobiology: Current Therapeutic Avenues and Future Perspective [0.03%]
NLRP3炎症小体在脑卒中病理生理中的作用：当前的治疗途径和未来展望
Kartik Panbhare,Rukmani Pandey,Chandan Chauhan et al.
Kartik Panbhare et al.
Neuroinflammation is a key pathophysiological feature of stroke-associated brain injury. A local innate immune response triggers neuroinflammation following a stroke via activating inflammasomes. The nucleotide-binding oligomerization domai...
Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro [0.03%]
重组全长TDP-43寡聚体保留其结合RNA的能力，无细胞毒性且不能使TDP-43聚集在体外种子生长
Lixin Yang,Yllza Jasiqi,Hilal Lashuel
Lixin Yang
TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberran...
TAT-Modified Martentoxin Displays Intravenous Antiseizure Activities [0.03%]
N-乙酰天冬氨酸修饰的石松毒碱具有静脉给药抗惊厥作用
Huan Liu,Dongxiao Qu,Yunzhu Cao et al.
Huan Liu et al.
Epilepsy is a chronic disease of brain dysfunction, which arises from imbalance between excitatory and inhibitory activities in neural circuits. Previously, we reported that peptide Martentoxin (MarTX), from scorpion Buthus martensii Karsch...
FTY720 Nanoformulation Induces O-GlcNacylation of Synuclein to Alleviate Synucleinopathy [0.03%]
纳米化FTY720通过O-GlcNAc修饰诱导突变型α-突触核蛋白聚集以缓解帕金森病模型小鼠的路易小体形成及神经炎症反应
Mohammed Nadim Sardoiwala,Mrunalini Boddu,Liku Biswal et al.
Mohammed Nadim Sardoiwala et al.
The post-translational modification and aggregation of alpha-synuclein are one of the major causes of Parkinson's disease (PD) regulation. In that, the phosphorylation and nitration of synuclein elevate the aggregation, while O-GlcNacylatio...
EPR Studies of Aβ42 Oligomers Indicate a Parallel In-Register β-Sheet Structure [0.03%]
EPR研究显示Aβ42寡聚体呈平行的/registerβ折叠结构
Chelsea Jang,Diana Portugal Barron,Lan Duo et al.
Chelsea Jang et al.
Aβ aggregation leads to the formation of both insoluble amyloid fibrils and soluble oligomers. Understanding the structures of Aβ oligomers is important for delineating the mechanism of Aβ aggregation and developing effective therapeutic...
Aggregation Dynamics Characteristics of Seven Different Aβ Oligomeric Isoforms-Dependence on the Interfacial Interaction [0.03%]
七种不同Aβ寡聚体异构体的聚集动力学特征及其界面相互作用依赖性
Yvning Guan,Ye Li,Wenqi Gao et al.
Yvning Guan et al.
The aggregation of β-amyloid (Aβ) peptides has been confirmed to be associated with the onset of Alzheimer's disease (AD). Among the three phases of Aβ aggregation, the lag phase has been considered to be the best time for early Aβ path...
On-Tissue Spatial Proteomics Integrating MALDI-MS Imaging with Shotgun Proteomics Reveals Soy Consumption-Induced Protein Changes in a Fragile X Syndrome Mouse Model [0.03%]
整合基质辅助激光解析电离质谱成像与宽覆盖定量蛋白质组学技术揭示人类脆弱性X综合症小鼠模型中大豆摄入引起的蛋白变化分布图
Min Ma,Qinying Yu,Daniel G Delafield et al.
Min Ma et al.
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability and autism, is caused by the transcriptional silencing of the FMR1 gene, which encodes the fragile X messenger ribonucleoprotein (FMRP). FMRP interacts with nu...
Role of NLRP3 Inflammasome in Post-Spinal-Cord-Injury Anxiety and Depression: Molecular Mechanisms and Therapeutic Implications [0.03%]
NLRP3炎症小体在脊髓损伤后焦虑和抑郁中的作用：分子机制及治疗意义
Tahmineh Mokhtari,Kadir Uludag
Tahmineh Mokhtari
The majority of research on the long-term effects of spinal cord injury (SCI) has primarily focused on neuropathic pain (NP), psychological issues, and sensorimotor impairments. Among SCI patients, mood disorders, such as anxiety and depres...
Sensitized Emission Imaging Allows Nanoscale Surface Polarity Mapping of α-Synuclein Amyloid Fibrils [0.03%]
敏化发射成像允许α-突触核蛋白淀粉样纤维纳米级表面极性映射
Jaladhar Mahato,Rajat Mukherjee,Abhik Bose et al.
Jaladhar Mahato et al.
When misfolded, α-Synuclein (α-Syn), a natively disordered protein, aggregates to form amyloid fibrils responsible for the neurodegeneration observed in Parkinson's disease. Structural studies revealed distinct molecular packing of α-Syn...