Cell-Free and In Vivo Characterization of the Inhibitory Activity of Lavado Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3 [0.03%]
来自无细胞体系和在体体系的实验对Lavado可可黄烷醇抑制Ataxin-3蛋白聚集活性的研究：为脊髓小脑性共济失调3型提出新疗法
Barbara Sciandrone,Alessandro Palmioli,Carlotta Ciaramelli et al.
Barbara Sciandrone et al.
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by ataxia and other neurological manifestations, with a poor prognosis and a lack of effective therapies. The amyloid aggregation of the ataxin-3 protein is ...
A Microfluidic High-Capacity Screening Platform for Neurological Disorders [0.03%]
用于神经障碍疾病的高容量筛选微流控平台
Lydia Moll,Johan Pihl,Mattias Karlsson et al.
Lydia Moll et al.
Compartmentalized cell cultures (CCCs) provide the possibility to study mechanisms of neurodegenerative diseases, such as spreading of misfolded proteins in Alzheimer's or Parkinson's disease or functional changes in, e.g., chronic pain, in...
Development of 2-Aminotetralin-Type Serotonin 5-HT1 Agonists: Molecular Determinants for Selective Binding and Signaling at 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1F Receptors [0.03%]
2-氨基四氢萘啉类血清素5-HT1受体激动剂的开发：分子决定因素对5-HT1A，5-HT1B，5-HT1D和5-HT1F受体的选择性结合及信号转导的作用
Ryan P McGlynn,Meng Cui,Brittany Brems et al.
Ryan P McGlynn et al.
The serotonin (5-hydroxytryptamine, 5-HT) 5-HT1 G-protein coupled receptor subtypes (5-HT1A/1B/1D/1E/1F) share a high sequence homology, confounding development of subtype-specific ligands. This study used a 5-HT1 structure-based ligand des...
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy [0.03%]
喹啉酮杂环化合物作为乙酰胆碱酯酶和淀粉样蛋白Aβ聚集的双重抑制剂在阿尔茨海默病治疗中的发现
Shoaib Manzoor,Moustafa T Gabr,Mohamed S Nafie et al.
Shoaib Manzoor et al.
The development of multitargeted therapeutics has evolved as a promising strategy to identify efficient therapeutics for neurological disorders. We report herein new quinolinone hybrids as dual inhibitors of acetylcholinesterase (AChE) and ...
Isolation and Identification of the High-Affinity DNA Aptamer Target to the Brain-Derived Neurotrophic Factor (BDNF) [0.03%]
针对脑源性神经营养因子(BDNF)靶标的高亲和力DNA适体的分离及鉴定
Md Anisuzzaman Chowdhury,Jessica M Collins,David A Gell et al.
Md Anisuzzaman Chowdhury et al.
Aptamers are functional oligonucleotide ligands used for the molecular recognition of various targets. The natural characteristics of aptamers make them an excellent alternative to antibodies in diagnostics, therapeutics, and biosensing. DN...
A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma [0.03%]
由LINC00265调控的转录因子ZNF384通过激活IFI30的表达来刺激胶质瘤恶性进展
Jian Yang,Shenghe Yang,Jinlian Cai et al.
Jian Yang et al.
Glioma remains one of the most challenging primary brain malignancies to treat. Long noncoding RNAs (lncRNAs) and mRNAs (mRNAs) are implicated in regulating the malignant phenotypes of cancers including glioma. This study aimed to elucidate...
Structural Dynamics Role of AGG Interruptions in Inhibition CGG Repeat Expansion Associated with Fragile X Syndrome [0.03%]
与脆性X综合征相关的CGG重复扩展抑制中的AGG中断的结构动态作用
Yang-I Shen,Kai-Chun Cheng,Yu-Jie Wei et al.
Yang-I Shen et al.
Abnormal expansion of trinucleotide CGG repeats is responsible for Fragile X syndrome. AGG interruptions in CGG repeat tracts were found in most healthy individuals, suggesting a crucial role in preventing disease-prone repeat expansion. Pr...
Multitracer Approach to Understanding the Complexity of Reactive Astrogliosis in Alzheimer's Brains [0.03%]
多示踪剂技术在阿尔茨海默大脑中对反应性星形胶质细胞增生复杂性的理解探索
Igor C Fontana,Amit Kumar,Nobuyuki Okamura et al.
Igor C Fontana et al.
A monoamine oxidase B (MAO-B) selective positron emission tomography (PET) tracer [11C]-deuterium-l-deprenyl holds promise for imaging reactive astrogliosis in neurodegenerative diseases, such as Alzheimer's disease (AD). Two novel PET trac...
Roles of Apigenin and Nepetin in the Assembly Behavior and Cytotoxicity of Prion Neuropeptide PrP106-126 [0.03%]
Apigenin和Nepetin在朊病毒神经肽PrP106-126组装行为及细胞毒性中的作用
Yan Huo,Cong Zhao,Yanan Wang et al.
Yan Huo et al.
Development of potential inhibitors to prevent prion protein (PrP) fibrillation is a therapeutic strategy for prion diseases. The prion neuropeptide PrP106-126, a research model of abnormal PrP (PrPSc), presents similar physicochemical and ...
SARS-CoV-2-Mimicking Pseudoviral Particles Accelerate α-Synuclein Aggregation In Vitro [0.03%]
模拟SARS-CoV-2的假病毒颗粒可加速α突触核蛋白的聚集反应
Gianluca Zilio,Anna Masato,Michele Sandre et al.
Gianluca Zilio et al.
Since the SARS-CoV-2 virus started spreading worldwide, evidence pointed toward an impact of the infection on the nervous system. COVID-19 patients present neurological manifestations and have an increased risk of developing brain-related s...