Exploration of Resveratrol as a Potent Modulator of α-Synuclein Fibril Formation [0.03%]
白藜芦醇作为α-突触核蛋白纤维形成的潜在调节因子的探索研究
Eva Illes-Toth,Don L Rempel,Michael L Gross
Eva Illes-Toth
The molecular determinants of amyloid protein misfolding and aggregation are key for the development of therapeutic interventions in neurodegenerative disease. Although small synthetic molecules, bifunctional molecules, and natural products...
Alexander M Sherwood,Elise K Burkhartzmeyer,Samuel E Williamson et al.
Alexander M Sherwood et al.
Primary metabolites of mushroom tryptamines, psilocybin and baeocystin (i.e., psilocin and norpsilocin), exhibit potent agonist activity at the serotonin 2A receptor (5-HT2A) in vitro but differ in their 5-HT2A-mediated effects in vivo. In ...
JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways [0.03%]
JE-133通过调节JAK / STAT和Nrf2信号通路抑制LPS诱导的神经炎症
Lingxue Tao,Weichen Yu,Ziyi Liu et al.
Lingxue Tao et al.
Neuroinflammation plays an important role in the pathogenesis of neurodegenerative diseases, and interrupting the microglial-mediated neuroinflammation has been suggested as a promising strategy to delay or prevent the progression of neurod...
Comparing Brain and Blood Lipidome Changes following Single and Repetitive Mild Traumatic Brain Injury in Rats [0.03%]
单次和重复性轻型脑外伤后大鼠脑部和血液脂质组变化的比较研究
Alexis N Pulliam,Eric C Gier,David A Gaul et al.
Alexis N Pulliam et al.
Traumatic brain injury (TBI) is a major health concern in the United States and globally, contributing to disability and long-term neurological problems. Lipid dysregulation after TBI is underexplored, and a better understanding of lipid tu...
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H-benzo[ f]imidazo[1,5- a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy [0.03%]
新的imidazodiazepine类似物，5-（8-溴-6-（吡啶-2-基）-4H-苯并[f]咪唑[1,5-a][1,4]二氮杂卓-3-基）恶唑，提供简化的合成方案，高口服血浆和脑部暴露，并在小鼠中产生抗癫痫功效，在来自伴有内侧颞叶癫痫患者的脑切片中的神经网络中具有抗癫痫发生活性。
Dishary Sharmin,Branka Divović,Xingjie Ping et al.
Dishary Sharmin et al.
KRM-II-81 (1) is an imidazodiazepine GABAA receptor (GABAAR) potentiator with broad antiseizure efficacy and a low sedative burden. A brominated analogue, DS-II-73 (5), was synthesized and pharmacologically characterized as a potential back...
Amyloid Targeting Red Emitting AIE Dots for Diagnostic and Therapeutic Application against Alzheimer's Disease [0.03%]
用于诊断和治疗阿尔茨海默病的淀粉样靶向红色发射AIE点
Priyam Ghosh,Kamal Shokeen,Subrata Mondal et al.
Priyam Ghosh et al.
The emergence of neurodegenerative diseases is connected to several pathogenic factors, including metal ions, amyloidogenic proteins, and reactive oxygen species. Recent studies suggest that cytotoxicity is caused by the small, dynamic, and...
Unlocking the Molecular Variations of a Micron-Scale Amyloid Plaque in an Early Stage Alzheimer's Disease by a Cellular-Resolution Mass Spectrometry Imaging Platform [0.03%]
细胞水平分辨率的质量 spectrometry 成像平台解析早期阿尔茨海默病中微米级淀粉样斑块的分子变化
Yueguang Lv,Shuxiong Yan,Ka Deng et al.
Yueguang Lv et al.
Uncovering the molecular changes at the site where Aβ is deposited plays a critical role in advancing the diagnosis and treatment of Alzheimer's disease. However, there is currently a lack of a suitable label-free imaging method with a hig...
Phospholipids and Cholesterol Determine Molecular Mechanisms of Cytotoxicity of α-Synuclein Oligomers and Fibrils [0.03%]
α-突触核蛋白寡聚物和纤维的细胞毒性的分子机制由磷脂和胆固醇决定
Kiryl Zhaliazka,Abid Ali,Dmitry Kurouski
Kiryl Zhaliazka
Progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta, hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked to the abrupt aggregation of α-synuclein (α-Syn), a small membr...
Ratiometric Fluorescent Probe Promotes Trans-differentiation of Human Mesenchymal Stem Cells to Neurons [0.03%]
比率荧光探针促进人类间充质干细胞向神经元转分化
Varsha Gupta,Prabir Kumar Gharai,Chirantan Kar et al.
Varsha Gupta et al.
Development of multifunctional theranostics is challenging and crucial for deciphering complex biological phenomena and subsequently treating critical disease. In particular, development of theranostics for traumatic brain injury (TBI) and ...
Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations [0.03%]
分子动力学模拟在Mfsd2a与NEDD4-2结合相互作用研究中的应用
Wen Yuan,Zhong-Ming Qiu,Hongwei Li et al.
Wen Yuan et al.
Major facilitator superfamily domain-containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine cotransporter that plays an important role in maintaining the integrity of the blood-brain barrier and neurological function. Abnormal...