Synaptotagmin III Plays a Protective Role in Neonatal Multiple Sevoflurane Exposure-Induced Cognitive Deficits in Mice [0.03%]
Synaptotagmin III在保护小鼠多次异氟醚暴露引起的认知缺陷中的作用
Yutong Gao,Ting Wu,Xiangdi Yu
Yutong Gao
General anesthesia in infants and young children raises concerns about potential neurodevelopmental effects, as anesthetics such as sevoflurane may impair cognitive function and increase neuroinflammation. Synaptotagmin 3 (Syt3), a protein ...
Neuroprotective Effects of a 3-Amino Quinazoline Derivative via Keap1-Nrf2 Pathway Activation in an ICV-STZ-Induced Rat Model of Sporadic Alzheimer's Disease [0.03%]
激活Keap1-Nrf2信号通路的3-氨基喹唑啉衍生物通过ICV-STZ诱导大鼠模型对散发性阿尔茨海默病发挥神经保护作用
Pranav Maheta,Chirag Patel,Dharmishtha Parmar et al.
Pranav Maheta et al.
The Keap1-Nrf2 pathway has emerged as a promising target for Alzheimer's disease (AD). This study employed in silico modeling to identify Nrf2 activators through Keap1 inhibition. The most promising quinazoline derivative, LMDP10, was then ...
Developing Intravenous Delivery of Water-Soluble Prodrugs of Idebenone for the Treatment of Acute Ischemic Stroke [0.03%]
用于急性缺血性卒中治疗的辅酶Q1乙酯水溶前药的静脉给药研发
Jian Jia,Huihao Wang,Weiwei Wang et al.
Jian Jia et al.
Ischemic stroke (IS) represents a substantial global health threat, but only a few effective medicines exist to treat IS, with a huge unmet clinical need. Idebenone (IDB), a coenzyme Q10 analogue, has multitarget effects, including enhancin...
Donepezil and Memantine Derivatives for Dual-Function and Prodrug Applications in Alzheimer's Disease [0.03%]
用于阿尔茨海默病的双功能和前药应用的多奈哌齐和美金刚衍生物
Karna Terpstra,Citlali Gutiérrez,Kai Gui et al.
Karna Terpstra et al.
The treatment of Alzheimer's disease by acetylcholinesterase (AChE) and N-methyl-d-aspartate receptor (NMDAR) inhibitors is limited by the narrow therapeutic window and adverse side effects of the drugs. This study aims to increase the effi...
Modulation of Amyloid-β Aggregation by Surface Proteins from Pathogens Associated with Alzheimer's Disease [0.03%]
病原菌表面蛋白调节与阿尔茨海默症相关的淀粉样蛋白聚集性
Antonin Kunka,Hana Hribkova,Tereza Vanova et al.
Antonin Kunka et al.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder. Despite substantial research efforts, our understanding of its pathogenesis remains incomplete, limiting the development of effective treatments and preventive strategies. ...
Cracking Amyloid Toxicity: Naringin Rescues Neuronal Cells in a Minimal Alzheimer's Model [0.03%]
淀粉样蛋白毒性的破解：在最小的阿尔茨海默病模型中柚皮素可拯救神经元细胞
Emre Korkmaz,Jülide Secerli,Hakan Erdoğan et al.
Emre Korkmaz et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, extracellular amyloid plaque accumulation, and neuronal dysfunction. The diphenylalanine (Phe-Phe) dipeptide, a core self-assembling mo...
7T GluCEST in Discriminating Gliomas with Diverse Invasiveness Degrees and Its Association with Invasion Indices [0.03%]
7T葡萄糖CEST在区分不同侵袭性的胶质瘤及其与浸润指数关联度中的应用
Shuyi Sun,Lingfeng Lai,Mingmin Wu et al.
Shuyi Sun et al.
This study aimed to evaluate and compare the effectiveness of glutamate chemical exchange saturation transfer (GluCEST) with that of proton MR spectroscopy (1H-MRS) and other conventional magnetic resonance imaging in distinguishing gliomas...
Progress toward Multianalyte Neurochemical Detection: Techniques and Applications [0.03%]
多分析物神经化学检测技术及应用研究进展
Kalynn M Turner,Jenna M Berger,Leslie A Sombers
Kalynn M Turner
Brain function is shaped by the coordinated activity of billions of neurons. The neurotransmitters and neuromodulators released from these neurons work together to modulate circuit function and, ultimately, behavior. Electroanalytical techn...
Neha Nanajkar,Abhilash Sahoo,Shelli L Frey et al.
Neha Nanajkar et al.
Nt17, the N-terminal domain of the huntingtin protein (htt), has garnered significant attention for its role in htt's membrane binding and aggregation processes. Previous studies have identified a nuclear export sequence within the Nt17 dom...
Design, Synthesis, and Biological Evaluation of Novel Heteroaryl, Squaramide, and Indolcarboxamide Derivatives as Formyl Peptide Receptor 2 Agonists to Target Neuroinflammation [0.03%]
新型杂芳基、squaramide和吲哚甲酰胺衍生物作为表皮生长因子受体2激动剂的设计、合成及生物学评价以靶向神经炎症
Fabio Francavilla,Daniele Vitone,Igor A Schepetkin et al.
Fabio Francavilla et al.
Recent research reveals Formyl Peptide Receptor 2 (FPR2) as a relevant G Protein-Coupled Receptor involved in the resolution phase of inflammation. Therefore, FPR2 agonists are promising agents to tackle neuroinflammatory-based diseases, su...