Modulation of Prostaglandin-Endoperoxide Synthase 1 by Caulis Sinomenii: A Novel Approach to Alleviating Diabetic Peripheral Neuropathy Through Apoptosis Inhibition and Anti-inflammatory Effects [0.03%]
青藤碱通过抑制凋亡和抗炎作用调控前列腺素内过氧化物合酶1：糖尿病性外周神经病变的治疗新策略研究
Lin Zhu,Ji Chen,Yuan Liu et al.
Lin Zhu et al.
Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of diabetes, characterized by neurodegeneration and chronic pain. This study investigates the potential of Caulis Sinomenii (CS), a traditional Chinese medicine,...
Properties of Acute Activation and Inhibition of the β3 Homomeric GABAA Receptor Mediated by Protonation of Conserved Histidine Residues [0.03%]
通过质子化保守组氨酸残基介导的β3同源五聚体GABA受体急性激活和抑制的动力学特性
Spencer R Pierce,Allison L Germann,Yu Zhou et al.
Spencer R Pierce et al.
GABAA receptors are inhibitory transmitter-gated ion channels formed of various combinations of the 19 homologous subunits cloned to date. Changes in extracellular pH have been shown to directly activate the receptor or modulate its activit...
Obacunone Alleviates Thalamic Pain via Promoting LCN2-Mediated Phagocytosis of Astrocytes in Mice [0.03%]
奥巴库诺通过促进小胶质细胞LCN2介导的星形胶质细胞吞噬作用缓解小鼠丘脑痛
Yue-Rong Li,Lin-Lin Xie,Hao-Bin Cai et al.
Yue-Rong Li et al.
Thalamic pain is a common pain syndrome following thalamic stroke with limited therapeutic options. Though the pathogenesis of thalamic pain is far from clear, accumulating studies have demonstrated that the ectopic activity of thalamic gli...
Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice [0.03%]
L-茶氨酸在缓解Scopolamine致小鼠认知障碍和神经病理损害中的治疗作用研究
Eman M Elbaz,Sherehan M Ibrahim,Eman Rashad et al.
Eman M Elbaz et al.
Memory decline is a prominent hallmark of Alzheimer's disease (AD). Scopolamine-induced amnesia is a pharmacological paradigm in AD research to model these cognitive insults. AD represents the most prevalent type of dementia among the elder...
Emerging Techniques for the Identification of Traditional Chinese Medicine-Derived Molecules Targeting Parkinson's Disease [0.03%]
针对帕金森病的中药来源活性分子的识别新技术探究
Yanzhuo Jin,Yurun Yang,Yiran Sun et al.
Yanzhuo Jin et al.
Parkinson's disease is a neurodegenerative disorder marked by the aggregation of α-synuclein and substantial loss of dopaminergic neurons. While numerous neuroprotective molecules targeting Parkinson's disease have been identified, challen...
The Neuroprotective Effects of the Crinoid Natural Compound Rhodoptilometrin in Parkinson's Disease Experimental Models: Implications for ER Stress and Autophagy Modulation [0.03%]
海星天然化合物Rhodoptilometrin在帕金森病实验模型中的神经保护作用：对内质网应激和自噬调节的意义
Zhi-Hong Wen,Ya-Jen Chiu,San-Nan Yang et al.
Zhi-Hong Wen et al.
The pathogenesis of Parkinson's disease (PD) involves cellular processes such as endoplasmic reticulum (ER) stress, unfolded protein response, autophagy imbalance, and apoptosis, and identifying drugs that can regulate these molecular mecha...
Altered Composition of Ceramides and Sphingomyelin Distinctly Modulates the Organizational Landscape and Microdomain Dynamics of Neuronal Plasma Membrane: A Computational Microscopy of Alzheimer's Brain [0.03%]
鞘氨醇脂类组成的变化调节阿尔茨海默病神经元质膜的组织结构和微域动力学：一种计算显微镜方法
Sruthi Peesapati,Sandipan Chakraborty
Sruthi Peesapati
Alzheimer's disease (AD) is one of the leading causes of death in the elderly population. Currently, there is no available therapy that can stop the disease progression. Situations are much worse due to a lack of a clear understanding of di...
Yuto Kado,Kenichi Kawano,Marie Nishikawa et al.
Yuto Kado et al.
The abnormal aggregation of amyloid β-protein (Aβ) and resultant neuronal damage are central to the pathogenesis of Alzheimer's disease. Accumulating evidence suggests that neuronal cell membranes play a pivotal role in Aβ self-aggregati...
Neurochemical, Neurocircuitry, and Psychopathological Mechanisms of PTSD: Emerging Pharmacotherapies and Clinical Perspectives [0.03%]
PTSD的神经化学、神经回路和心理病理学机制：新兴的药物疗法和临床观点
Santosh Kumar Prajapati,Shreyasi Majumdar,Snehapriya Murari et al.
Santosh Kumar Prajapati et al.
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition triggered by exposure to traumatic events, with complex neurobiological anomalies that remain incompletely understood. This review aims to comprehensively explore...
Fluorescence Lifetime-Based FRET Biosensors for Monitoring N Terminal Domain-Dependent Interactions of TDP-43 in Living Cells: A Novel Approach for ALS and FTD Drug Discovery [0.03%]
用于活细胞中TDP-43N末端结构域依赖性相互作用监测的荧光寿命型FRET生物传感器：ALS和FTD药物发现的新方法
Noah Nathan Kochen,Marguerite Murray,Sophia Zafari et al.
Noah Nathan Kochen et al.
Pathological aggregates of TDP-43 are implicated in Alzheimer's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. While therapeutic efforts have traditionally focused on mitigating end-stage TDP-43 aggregation, recent evi...