Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies [0.03%]
通过计算模拟确定人和大鼠磷酸化BACE1在配体识别中的结构变化及其通过体外研究在Thr252处的GSK3β磷酸化
Jazziel Velazquez Toledano,Martiniano Bello,José Correa Basurto et al.
Jazziel Velazquez Toledano et al.
Alzheimer's disease (AD) is a neurodegenerative disease affecting older adults. AD pathogenesis involves the production of the highly neurotoxic amyloid-β peptide 1-42 (Aβ1-42) from β-site amyloid precursor protein cleaving enzyme 1 (BAC...
Antidepressant-like Effect of the Eburnamine-Type Molecule Vindeburnol in Rat and Mouse Models of Ultrasound-Induced Depression [0.03%]
伊贝卡品类化合物Vindeburnol对超声诱导抑郁大鼠和小鼠模型的抗抑郁样作用
Eugene Zubkov,Olga Riabova,Yana Zorkina et al.
Eugene Zubkov et al.
Vindeburnol (VIND, RU24722, BC19), a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological effects, but its antidepressant-like effects are poorly understood and have only been describe...
Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise [0.03%]
抗衰老策略与疗法：研究进展与前景概览
Rumiana Tenchov,Janet M Sasso,Xinmei Wang et al.
Rumiana Tenchov et al.
Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with ...
Pedro A M Mediano,Fernando E Rosas,Christopher Timmermann et al.
Pedro A M Mediano et al.
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes, such as personality changes. Thes...
Unraveling the Interplay of Dopamine, Carbon Monoxide, and Heme Oxygenase in Neuromodulation and Cognition [0.03%]
多巴胺、一氧化碳和血红素氧合酶在神经调节和认知中的相互作用解析
Nicola Bauer,Dongning Liu,TanPhat Nguyen et al.
Nicola Bauer et al.
The dopaminergic system plays important roles in neuromodulation, including prominent roles in complex neurological functions such as cognition, reward, motivation, and memory. Understandably, the highly complex nature of such physiological...
Borneol-Modified Schisandrin B Micelles Cross the Blood-Brain Barrier To Treat Alzheimer's Disease in Aged Mice [0.03%]
治疗老年小鼠阿尔茨海默病的穿山甲改性Schisandrin B胶束穿越血脑屏障
Feng-Rui Li,Yang Yu,Yu-Meng Du et al.
Feng-Rui Li et al.
Objective: Schisandrin B (Sch B) is a bioactive dibenzocyclooctadiene derizative that is prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated that Sch B has a neuroprotective action by reducing oxidative stress...
A Near-infrared Fluorescence and Positron Emission Tomography Bimodal Probe for In Vivo Imaging of Amyloid-β Species [0.03%]
用于活体成像淀粉样-β物质的近红外荧光和正电子发射断层扫描双模式探测器
Daqing Fang,Donghui Pan,Xidan Wen et al.
Daqing Fang et al.
Noninvasive imaging of amyloid-β (Aβ) species in vivo is important for the early diagnosis of Alzheimer's disease (AD). In this paper, we report a near-infrared (NIR) fluorescence (FL) and positron emission tomography (PET) bimodal probe ...
Amyloid Modifier SERF1a Accelerates Alzheimer's Amyloid-β Fibrillization and Exacerbates the Cytotoxicity [0.03%]
SERF1a通过加速阿尔兹海默症淀粉样蛋白纤维化而加重细胞毒性
Tien-Ying Tsai,Wei-Ting Jhang,Hung-Kai Hsu et al.
Tien-Ying Tsai et al.
Alzheimer's disease (AD) is a devastating, progressive neurodegenerative disease affecting the elderly in the world. The pathological hallmark senile plaques are mainly composed of amyloid-β (Aβ), in which the main isoforms are Aβ40 and ...
Chemoenzymatic Synthesis of GAA-7 Glycan Analogues and Evaluation of Their Neuritogenic Activities [0.03%]
GAA-7糖基类似物的酶化学合成及其神经突生长活性评估
Hsin-Kai Tseng,Yung-Yu Su,Po-Jen Lai et al.
Hsin-Kai Tseng et al.
Ganglioside GAA-7 exhibits higher neurite outgrowth than ganglioside GM1a and most echinodermatous gangliosides (EGs) when tested on neuron-like rat adrenal pheochromocytoma (PC12) cells in the presence of nerve growth factor (NGF). The uni...
Patients with Neurodegenerative Proteinopathies Exhibit Altered Tryptophan Metabolism in the Serum and Cerebrospinal Fluid [0.03%]
神经变性蛋白病患者的血清和脑脊液中色氨酸代谢改变
Michal Kaleta,Eva Hényková,Kateřina Menšíková et al.
Michal Kaleta et al.
Some pathological conditions affecting the human body can also disrupt metabolic pathways and thus alter the overall metabolic profile. Knowledge of metabolic disturbances in specific diseases could thus enable the differential diagnosis of...