Coronal ApoE Protein Combines with LRP1 to Inactivate GSK3β That Mitigates Silica Nanoparticle-Induced Brain Lesion [0.03%]
冠状ApoE蛋白与LRP1结合灭活GSK3β以减轻纳米硅诱导的脑损伤
Wei Wei,Hang Sun,Bingwei Yang et al.
Wei Wei et al.
Silica nanoparticles (SiO2 NPs) are widely used engineered materials that warrant their obvious environmental exposure risk. Our previous study has shown that different routes of SiO2 NP exposure on the glycogen synthase kinase 3 beta (GSK3...
Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models [0.03%]
解开细胞外结构域构象变化与甲状旁腺激素受体1激活之间的相互作用在B1类G蛋白偶联受体中：结合增强采样分子动力学模拟和马尔可夫状态模型
Mengrong Li,Xiaoxiao Zhang,Shu Li et al.
Mengrong Li et al.
Parathyroid hormone (PTH) type 1 receptor (PTH1R), as a typical class B1 G protein-coupled receptor (GPCR), is responsible for regulating bone turnover and maintaining calcium homeostasis, and its dysregulation has been implicated in the de...
Maria do Socorro do Nascimento Amorim,Álefe Roger Silva França,Ralph Santos-Oliveira et al.
Maria do Socorro do Nascimento Amorim et al.
Atomic force microscopy (AFM) is a scanning probe microscopy technique which has a physical principle, the measurement of interatomic forces between a very thin tip and the surface of a sample, allowing the obtaining of quantitative data at...
Caged Zn2+ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake [0.03%]
斑马鱼全脑中笼状Zn2+光解揭示多巴胺摄取的亚秒级调制
Piyanka Hettiarachchi,Sayuri Niyangoda,Austin Shigemoto et al.
Piyanka Hettiarachchi et al.
Free, ionic zinc (Zn2+) modulates neurotransmitter dynamics in the brain. However, the sub-s effects of transient concentration changes of Zn2+ on neurotransmitter release and uptake are not well understood. To address this lack of knowledg...
Spatial Neurolipidomics at the Single Amyloid-β Plaque Level in Postmortem Human Alzheimer's Disease Brain [0.03%]
单个淀粉样-β斑块水平上的空间神经类脂组学在阿尔茨海默病大脑中的应用
Wojciech Michno,Andrew Bowman,Durga Jha et al.
Wojciech Michno et al.
Lipid dysregulations have been critically implicated in Alzheimer's disease (AD) pathology. Chemical analysis of amyloid-β (Aβ) plaque pathology in transgenic AD mouse models has demonstrated alterations in the microenvironment in the dir...
Paeonol Derivative, 6'-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer's Disease Mice Model [0.03%]
山奈素衍生物6'-甲基山奈酚减轻阿尔茨海默病小鼠模型中皮质神经元内Aβ诱导的病理生理变化
Pin-Jung Chen,Chien-An Yao,Po-Chung Chien et al.
Pin-Jung Chen et al.
Herbs themselves and various herbal medicines are great resources for discovering therapeutic drugs for various diseases, including Alzheimer's disease (AD), one of the common neurodegenerative diseases. Utilizing mouse primary cortical neu...
Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling [0.03%]
含GluN2D的NMDA受体的抑制通过激活ERK/NRF2/HO-1信号通路保护多巴胺能神经元免受6-OHDA诱导的神经毒性
Jin-Bao Zhang,Fen Wang,Yu-Ting Tang et al.
Jin-Bao Zhang et al.
Abnormal glutamate signaling is implicated in the heightened vulnerability of dopaminergic neurons in Parkinson's disease (PD). NMDA receptors are ion-gated glutamate receptors with high calcium permeability, and their GluN2D subunits are p...
Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity [0.03%]
伊曲茶碱光敏感性对腺苷A2A受体的光学控制
Anaëlle Dumazer,Xavier Gómez-Santacana,Fanny Malhaire et al.
Anaëlle Dumazer et al.
In recent years, there has been growing interest in the potential therapeutic use of inhibitors of adenosine A2A receptors (A2AR) for the treatment of neurodegenerative diseases and cancer. Nevertheless, the widespread expression of A2AR th...
Inhibition of Seizure-Like Paroxysms and Toxicity Effects of Securidaca longepedunculata Extracts and Constituents in Zebrafish Danio rerio [0.03%]
Securidaca longepedunculata提取物及其成分对斑马鱼Danio rerio类似癫痫阵发和毒性效应的抑制作用
Nastaran Moussavi,Wietske van der Ent,Drissa Diallo et al.
Nastaran Moussavi et al.
Plants used in traditional medicine in the management of epilepsy could potentially yield novel drug compounds with antiepileptic properties. The medicinal plant Securidaca longepedunculata is widely used in traditional medicine in the Afri...
Characterization of Hair Metabolome in 5xFAD Mice and Patients with Alzheimer's Disease Using Mass Spectrometry-Based Metabolomics [0.03%]
基于质谱代谢组学对5xFAD小鼠和阿尔茨海默病患者毛发代谢组特征的分析
Chih-Wei Chang,Jen-Yi Hsu,Yu-Tai Lo et al.
Chih-Wei Chang et al.
Hair emerged as a biospecimen for long-term investigation of endogenous metabolic perturbations, reflecting the chemical composition circulating in the blood over the past months. Despite its potential, the use of human hair for metabolomic...