Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay [0.03%]
在斑马鱼幼虫试验中比较GABAergic低效能和高效能神经活性类固醇的行为影响
Allison L Germann,Yuanjian Xu,Douglas F Covey et al.
Allison L Germann et al.
Activation of the GABAA receptor is associated with numerous behavioral end points ranging from anxiolysis to deep anesthesia. The specific behavioral effect of a GABAergic compound is considered to correlate with the degree of its function...
SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats [0.03%]
SCFAs补充剂可挽救由难治性抑郁症大鼠粪便移植产生的类焦虑和抑郁表型
Mani Surya Kumar Palepu,Siva Nageswara Rao Gajula,Malleshwari K et al.
Mani Surya Kumar Palepu et al.
Alteration of gut microbiota and microbial metabolites such as short-chain fatty acids (SCFAs) coexisted with stress-generated brain disorders, including depression. Herein, we investigated the effect of SCFAs in a treatment-resistant depre...
Uncovering Structure-Activity Relationships of Phenethylamines: Paving the Way for Innovative Mental Health Treatments [0.03%]
揭示苯乙胺的结构活性关系：为精神健康治疗创新铺平道路
Sedat Karabulut,Harpreet Kaur,James W Gauld
Sedat Karabulut
The rapidly evolving psychedelic industry has garnered considerable attention due to 3,4-methylenedioxymethamphetamine-assisted psychotherapy's ground-breaking success in treating moderate-to-severe Post-traumatic Stress Disorder in two Pha...
A Bright Future? A Perspective on Class C GPCR Based Genetically Encoded Biosensors [0.03%]
光明的未来？基于类CGPCR的遗传编码生物传感器的视角
Margulan Otanuly,Martin Kubitschke,Olivia Andrea Masseck
Margulan Otanuly
One of the major challenges in molecular neuroscience today is to accurately monitor neurotransmitters, neuromodulators, peptides, and various other biomolecules in the brain with high temporal and spatial resolution. Only a comprehensive u...
Edge Substitution Effects of Histidine Tautomerization Behaviors on the Structural Properties and Aggregation Properties of Aβ(1-42) Mature Fibril [0.03%]
组氨酸互变异构对Aβ(1-42)成熟纤维结构属性和聚集属性的边缘替代效应
Yaru Shi,Yue Sun,Changgui Li et al.
Yaru Shi et al.
Histidine behaviors play critical roles in folding and misfolding processes due to the changes in net charge and the various N/N-H orientations on imidazole rings. However, the effect of histidine tautomerization (HIE (Nε-H, ε) and HID (N...
Behavioral and Neurophysiological Implications of Pathological Human Tau Expression in Serotonin Neurons [0.03%]
人异常tau蛋白在血清素神经元中表达的行为与生理影响
Nazmus S Khan,Juan Uribe Isaza,Nahid Rouhi et al.
Nazmus S Khan et al.
Alzheimer's disease (AD) is a progressive degenerative disorder that results in a severe loss of brain cells and irreversible cognitive decline. Memory problems are the most recognized symptoms of AD. However, approximately 90% of patients ...
Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition [0.03%]
PSMA/GCPII缺乏的小鼠模型的并行代谢组学和脂质组学揭示了NAAG水平和脑脂质组成的改变
František Sedlák,Aleš Kvasnička,Barbora Marešová et al.
František Sedlák et al.
Glutamate carboxypeptidase II (GCPII, also known as PSMA or FOLH1) is responsible for the cleavage of N-acetyl-aspartyl-glutamate (NAAG) to N-acetyl-aspartate and glutamate in the central nervous system and facilitates the intestinal absorp...
Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms [0.03%]
血清素-谷氨酸共释放神经元在急性应激机制中作用的证据
L Sophie Gullino,Cara Fuller,Poppy Dunn et al.
L Sophie Gullino et al.
A major subpopulation of midbrain 5-hydroxytryptamine (5-HT) neurons expresses the vesicular glutamate transporter 3 (VGLUT3) and co-releases 5-HT and glutamate, but the function of this co-release is unclear. Given the strong links between...
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo [0.03%]
具有新型双重作用的靶向两种类型 cannabinoid 体和乙酰胆碱酯酶活力的杂合分子显示了离体神经保护作用及体内认知障碍的改善作用
Claudia Mugnaini,Antonella Brizzi,Marco Paolino et al.
Claudia Mugnaini et al.
Alzheimer's disease (AD) is a neurodegenerative form of dementia characterized by the loss of synapses and a progressive decline in cognitive abilities. Among current treatments for AD, acetylcholinesterase (AChE) inhibitors have efficacy l...
Amyloidogenic Propensity of Metabolites in the Uric Acid Pathway and Urea Cycle Critically Impacts the Etiology of Metabolic Disorders [0.03%]
与尿酸途径和尿素循环代谢物异常聚集倾向相关的代谢紊乱病因学关键问题
Monisha Patel,Ankita Jaiswal,Anam Naseer et al.
Monisha Patel et al.
Novel insights into the etiology of metabolic disorders have recently been uncovered through the study of metabolite amyloids. In particular, inborn errors of metabolism (IEMs), including gout, Lesch-Nyhan syndrome (LNS), xanthinuria, citru...