Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids [0.03%]
多生物样本中可能的多发性硬化症代谢标志物
Fatema Bhinderwala,Heidi E Roth,Mary Filipi et al.
Fatema Bhinderwala et al.
Multiple sclerosis (MS) is a chronic and progressive neurological disorder without a cure, but early intervention can slow disease progression and improve the quality of life for MS patients. Obtaining an accurate diagnosis for MS is an ard...
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions [0.03%]
不同金属离子稳定的不同结构Aβ寡聚体的神经毒性效应的关系研究
Sean Chia,Rodrigo Lessa Cataldi,Francesco Simone Ruggeri et al.
Sean Chia et al.
Oligomeric assemblies of the amyloid β peptide (Aβ) have been investigated for over two decades as possible neurotoxic agents in Alzheimer's disease. However, due to their heterogeneous and transient nature, it is not yet fully establishe...
Reduction of Amyloid-β Production without Inhibiting Secretase Activity by MS-275 [0.03%]
通过MS-275降低Amyloid-β的生成而不抑制secretase活性
Yachiyo Mitsuishi,Masaki Nakano,Hirotatsu Kojima et al.
Yachiyo Mitsuishi et al.
Brain amyloid-β (Aβ) governs the pathogenic process of Alzheimer's disease. Clinical trials to assess the disease-modifying effects of inhibitors or modulators of β- and γ-secretases have not shown clinical benefit and can cause serious...
Extracellular Vesicles Slow Down Aβ(1-42) Aggregation by Interfering with the Amyloid Fibril Elongation Step [0.03%]
胞外囊泡通过干扰淀粉样纤维生长而延缓Aβ(1-42)聚集过程
Vesa Halipi,Nima Sasanian,Julia Feng et al.
Vesa Halipi et al.
Formation of amyloid-β (Aβ) fibrils is a central pathogenic feature of Alzheimer's disease. Cell-secreted extracellular vesicles (EVs) have been suggested as disease modulators, although their exact roles and relations to Aβ pathology re...
New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System [0.03%]
新的多靶点分子作为胆碱能系统的增效剂来源自咖啡因
Juan Pablo Munafó,Brunella Biscussi,Diego Obiol et al.
Juan Pablo Munafó et al.
Cholinergic deficit is a characteristic factor of several pathologies, such as myasthenia gravis, some types of congenital myasthenic syndromes, and Alzheimer's Disease. Two molecular targets for its treatment are acetylcholinesterase (AChE...
Beyond CSF and Neuroimaging Assessment: Evaluating Plasma miR-145-5p as a Potential Biomarker for Mild Cognitive Impairment and Alzheimer's Disease [0.03%]
超越脑脊液和神经影像评估：评价血浆miR-145-5p作为轻度认知障碍和阿尔茨海默病的潜在生物标志物的可能性
Qingfeng Wen,Mandy Melissa Jane Wittens,Sebastiaan Engelborghs et al.
Qingfeng Wen et al.
Alzheimer's disease (AD) is the most common cause of dementia. New strategies for the early detection of MCI and sporadic AD are crucial for developing effective treatment options. Current techniques used for diagnosis of AD are invasive an...
Anastasiia A Stepanchuk,Peter K Stys
Anastasiia A Stepanchuk
Protein misfolding has been extensively studied in the context of neurodegenerative disorders and systemic amyloidoses. Due to misfolding and aggregation of proteins being highly heterogeneous and generating a variety of structures, a growi...
Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R [0.03%]
靶向5-HT7R的G蛋白和β-arrestin信号通路的拮抗剂的鉴定
Jeong Hyun Jeong,Haeun Lee,Doyoung Kim et al.
Jeong Hyun Jeong et al.
In consideration of the limited number of FDA-approved drugs for autism spectrum disorder (ASD), significant efforts have been devoted to identifying novel drug candidates. Among these, 5-HT7R modulators have garnered considerable attention...
Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay [0.03%]
在斑马鱼幼虫试验中比较GABAergic低效能和高效能神经活性类固醇的行为影响
Allison L Germann,Yuanjian Xu,Douglas F Covey et al.
Allison L Germann et al.
Activation of the GABAA receptor is associated with numerous behavioral end points ranging from anxiolysis to deep anesthesia. The specific behavioral effect of a GABAergic compound is considered to correlate with the degree of its function...
SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats [0.03%]
SCFAs补充剂可挽救由难治性抑郁症大鼠粪便移植产生的类焦虑和抑郁表型
Mani Surya Kumar Palepu,Siva Nageswara Rao Gajula,Malleshwari K et al.
Mani Surya Kumar Palepu et al.
Alteration of gut microbiota and microbial metabolites such as short-chain fatty acids (SCFAs) coexisted with stress-generated brain disorders, including depression. Herein, we investigated the effect of SCFAs in a treatment-resistant depre...