Neuroprotection Role of Vitamin C by Upregulating Glutamate Transporter-1 in Auditory Cortex of Noise-Induced Tinnitus Animal Model [0.03%]
维生素C通过上调听皮层谷氨酸转运蛋白-1发挥神经保护作用于噪声诱导的耳鸣动物模型中
Wanxin Cao,Shan Xiong,Wenliang Ji et al.
Wanxin Cao et al.
Vitamin C (Vc) plays a pivotal role in a series of pathological processes, such as tumors, immune diseases, and neurological disorders. However, its therapeutic potential for tinnitus management remains unclear. In this study, we find that ...
Nav1.7 Modulator Bearing a 3-Hydroxyindole Backbone Holds the Potential to Reverse Neuropathic Pain [0.03%]
具有3-羟吲哚骨架的Nav1.7调节剂有逆转神经性疼痛的能力
Yuwei Wang,Jirong Shu,Haoyi Yang et al.
Yuwei Wang et al.
Chronic pain is a growing global health problem affecting at least 10% of the world's population. However, current chronic pain treatments are inadequate. Voltage-gated sodium channels (Navs) play a pivotal role in regulating neuronal excit...
EB1 Increases the Dynamics of Tau Droplets and Inhibits Tau Aggregation: Implications in Tauopathies [0.03%]
EB1增加Tau液滴的动态并抑制Tau聚集：在tau病理学中的意义
Anuradha Venkatramani,Anvesh Ashtam,Dulal Panda
Anuradha Venkatramani
EB1, a microtubule plus end-tracking protein (+TIP), regulates microtubule dynamics. Recent evidence indicates cross-talk between EB proteins and tau, a microtubule-associated neuronal protein that is important for the growth and stability ...
Phytic Acid Maintains Peripheral Neuron Integrity and Enhances Survivability against Platinum-Induced Degeneration via Reducing Reactive Oxygen Species and Enhancing Mitochondrial Membrane Potential [0.03%]
植酸通过降低 reactive oxygen species 和增强线粒体膜电位来维持外周神经的完整性并提高抵抗铂诱导变性的存活能力
Arjun Prasad Tiwari,Bayne Albin,Khayzaran Qubbaj et al.
Arjun Prasad Tiwari et al.
Phytic acid (PA) has been reported to possess anti-inflammatory and antioxidant properties that are critical for neuroprotection in neuronal disorders. This raises the question of whether PA can effectively protect sensory neurons against c...
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases [0.03%]
组胺H3受体和胆碱酯酶的多重靶向配体：4-氧代哌啶醚
Beata Michalska,Marek Dzięgielewski,Justyna Godyń et al.
Beata Michalska et al.
This study examines the properties of a novel series of 4-oxypiperidines designed and synthesized as histamine H3R antagonists/inverse agonists based on the structural modification of two lead compounds, viz., ADS003 and ADS009. The product...
Deciphering the Association of Epstein-Barr Virus and Its Glycoprotein M Peptide with Neuropathologies in Mice [0.03%]
Epstein-Barr病毒及其糖蛋白M肽与小鼠神经病理改变的相关性解析
Annu Rani,Priyanka Patra,Tarun Prakash Verma et al.
Annu Rani et al.
The reactivation of ubiquitously present Epstein-Barr virus (EBV) is known to be involved with numerous diseases, including neurological ailments. A recent in vitro study from our group unveiled the association of EBV and its 12-amino acid ...
Reversible Morphological Remodeling of Prefrontal and Hippocampal Serotonergic Fibers by Fluoxetine [0.03%]
氟西汀对前额皮质和海马5-羟色胺能纤维的可逆性形态重塑
Serena Nazzi,Marta Picchi,Sara Migliarini et al.
Serena Nazzi et al.
Serotonin-releasing fibers depart from the raphe nuclei to profusely innervate the entire central nervous system, displaying in some brain regions high structural plasticity in response to genetically induced abrogation of serotonin synthes...
Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics [0.03%]
盐诱导的动态对Tau纤维形成的初级和次级过程的调节作用
Arshad Abdul Vahid,Muhammed Shafeek Oliyantakath Hassan,Allwin Ebenezer Sahayaraj et al.
Arshad Abdul Vahid et al.
The initial stages of amyloid fibrilization begin with the monomers populating aggregation-prone conformers. Characterization of such aggregation-prone conformers is crucial in the study of neurodegenerative diseases. The current study char...
A Toxicogenic Interaction between Intracellular Amyloid-β and Apolipoprotein-E [0.03%]
细胞内淀粉样蛋白-β与载脂蛋白E之间的毒性相互作用
Arpan Dey,Aditi Verma,Uchit Bhaskar et al.
Arpan Dey et al.
Alzheimer's disease (AD) is associated with the aggregation of amyloid β (Aβ) and tau proteins. Why ApoE variants are significant genetic risk factors remains a major unsolved puzzle in understanding AD, although intracellular interaction...
Sex-Specific Transcriptomic Changes in the Villous Tissue of Placentas of Pregnant Women Using a Selective Serotonin Reuptake Inhibitor [0.03%]
使用选择性五羟色胺再摄取抑制剂的孕妇胎盘绒毛组织的性别特异性转录组变化
Laura Staal,Torsten Plösch,Theodora Kunovac Kallak et al.
Laura Staal et al.
About 5% of pregnant women are treated with selective serotonin reuptake inhibitor (SSRI) antidepressants to treat their depression. SSRIs influence serotonin levels, a key factor in neural embryonic development, and their use during pregna...