Influence of Cigarette Aerosol in Alpha-Synuclein Oligomerization and Cell Viability in SH-SY5Y: Implications for Parkinson's Disease [0.03%]
香烟气溶胶对SH-SY5Y细胞中Alpha-突触核蛋白寡聚化和细胞活力的影响：对帕金森病的启示
Yu-Xin Shen,Pe-Shuen Lee,Ming-Chu Teng et al.
Yu-Xin Shen et al.
Although cigarette aerosol exposure is associated with various adverse health issues, its impact on Parkinson's disease (PD) remains elusive. Here, we investigated the effect of cigarette aerosol extract (CAE) on SH-SY5Y cells for the first...
Structures and Dynamics of β-Rich Oligomers of ATTR (105-115) Assembly [0.03%]
ATTR (105-115)寡聚体的β丰富结构及动态组装过程
Liqun Liang,Yuqi Zhang,Yanyan Zhu et al.
Liqun Liang et al.
Transthyretin (TTR) is a tetrameric homologous protein that can dissociate into monomers. Misfolding and aggregation of TTR can lead to amyloid transthyretin amyloidosis (ATTR), which can cause many diseases (e.g., senile systemic amyloidos...
Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays [0.03%]
仍在寻找EAAT激动剂：GT949不会在阻抗和放射配体摄取测定中激活EAAT2或EAAT3
Lieve van Veggel,Tamara A M Mocking,Hubert J Sijben et al.
Lieve van Veggel et al.
Excitatory amino acid transporters (EAATs) are important regulators of amino acid transport and in particular glutamate. Recently, more interest has arisen in these transporters in the context of neurodegenerative diseases. This calls for w...
Patient-Derived Blood-Brain Barrier Model for Screening Copper Bis(thiosemicarbazone) Complexes as Potential Therapeutics in Alzheimer's Disease [0.03%]
用于筛选铜双(硫代半乳糖胺)复合物作为治疗阿尔茨海默病潜在药物的患者来源的血脑屏障模型
Joanna M Wasielewska,Kathryn Szostak,Lachlan E McInnes et al.
Joanna M Wasielewska et al.
Alzheimer's disease (AD) is the most prevalent cause of dementia characterized by a progressive cognitive decline. Addressing neuroinflammation represents a promising therapeutic avenue to treat AD; however, the development of effective ant...
Alleviating Severe Cytoskeletal Destruction of Spinal Motor Neurons: Another Effect of Docosahexaenoic Acid in Spinal Cord Injury [0.03%]
二十二碳六烯酸对脊髓损伤的功能作用机制研究进展——减轻脊髓运动神经元严重的细胞骨架破坏
Qinqin Pei,Qiurong Zhao,Chunhui Lang et al.
Qinqin Pei et al.
Spinal cord injury (SCI) treatment remains a major challenge. Spinal motor neurons (MNs) are seriously injured in the early stage after SCI, but this has not received sufficient attention. Oxidative stress is known to play a crucial role in...
Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders [0.03%]
理性设计TDP-43衍生的α-螺旋肽抑制剂：一种预防神经退行性疾病中TDP-43聚集的计算机模拟策略
Muthu Raj Salaikumaran,Pallavi P Gopal
Muthu Raj Salaikumaran
TDP-43, an essential RNA/DNA-binding protein, is central to the pathology of neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia. Pathological mislocalization and aggregation of TDP-43 disrupt RNA s...
Kynurenines Dynamics in the Periphery and Central Nervous System Steers Behavioral Deficits in Rats under Hypobaric Hypoxia [0.03%]
低压缺氧大鼠外周和中枢神经系统中犬尿氨酸的动态变化导致行为缺陷
Kalyani Verma,Amitabh,Dipti N Prasad et al.
Kalyani Verma et al.
People travel to high-altitude regions as tourists, workers, and military personnel on duty. Despite the consistent 21% oxygen content in the atmosphere, ascending to higher altitudes results in a decrease in the partial pressure of oxygen,...
18F-Labeled PET Tracers Specific for Adenosine A2A Receptor: Design, Synthesis, and Biological Evaluation [0.03%]
特异性腺苷A2A受体的18F-标记PET示踪剂：设计，合成和生物活性评价
Tingyu Yang,Wei Zheng,Xuebo Cheng et al.
Tingyu Yang et al.
By modifying the structures of targeted A2AR antagonists and tracers, novel compounds 3, 7a, 9, 12c, and BIBD-399 were designed and synthesized. In vitro inhibition experiments demonstrated that 3, 12c, and BIBD-399 have high affinity for A...
Aryl Hydrocarbon Receptor Involvement in the Sodium-Dependent Glutamate/Aspartate Transporter Regulation in Cerebellar Bergmann Glia Cells [0.03%]
芳烃受体在小脑伯尔曼胶质细胞中对钠依赖性谷氨酸/天冬氨酸转运载体的调节中的作用
Janisse Silva-Parra,Leticia Ramírez-Martínez,Cecilia Palafox-Gómez et al.
Janisse Silva-Parra et al.
Glutamate, the major excitatory neurotransmitter in the vertebrate brain, exerts its functions through the activation of specific plasma membrane receptors and transporters. Overstimulation of glutamate receptors results in neuronal cell de...
Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease [0.03%]
m-磺酰基苯甲脒衍生物作为选择性丁酸胆碱酯酶抑制剂用于治疗阿尔茨海默病的发现、结构优化以及体内外活性和分子对接研究
Xin Lu,Yueqing Li,Qianwen Guan et al.
Xin Lu et al.
For the potential therapy of Alzheimer's disease (AD), butyrylcholinesterase (BChE) has gradually gained worldwide interest in the progression of AD. This study used a pharmacophore-based virtual screening (VS) approach to identify Z3243994...