Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress [0.03%]
孕期接触氟西汀影响青春期大鼠急性应激诱导的前额叶皮层糖皮质激素受体介导的活动
Maria Teresa Gallo,Beatrice Dolci,Fabio Fumagalli et al.
Maria Teresa Gallo et al.
Any deviation from the programmed processes of brain development may modify its formation and functions, thereby precipitating pathological conditions, which often become manifest in adulthood. Exposure to a challenge during crucial periods...
Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain [0.03%]
新型氯胺酮代谢产物的鉴定及其在哺乳动物脑内的分布规律
Theodosia Vallianatou,Carina de Souza Anselmo,Ioanna Tsiara et al.
Theodosia Vallianatou et al.
Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine'...
Rapid FRET Assay for the Early Detection of Alpha-Synuclein Aggregation in Parkinson's Disease [0.03%]
帕金森病中快速FRET测定法早期检测α-突触核蛋白聚集
Hang Yu,Rui Feng,Fenglin Chen et al.
Hang Yu et al.
Alpha-synuclein (α-Syn) is a key protein of Parkinson's disease (PD). Oligomers formed by misfolding and aggregation of α-Syn can cause many pathological phenomena and aggravate the development of PD. Therefore, sensitive and accurate det...
Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation [0.03%]
天然渗透溶质对可塑性tau单体的影响：寡聚化和聚集的倾向性研究
Sharif Arar,Md Anzarul Haque,Nemil Bhatt et al.
Sharif Arar et al.
The pathological misfolding and aggregation of the microtubule associated protein tau (MAPT), a full length Tau2N4R with 441aa, is considered the principal disease relevant constituent in tauopathies including Alzheimer's disease (AD) with ...
Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues [0.03%]
无标签直接分析阿尔茨海默病大脑组织切片中淀粉样蛋白斑块的化学成分
James Everett,Jake Brooks,Vindy Tjendana Tjhin et al.
James Everett et al.
The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer's disease. Altered metabolism of essential biometals is another feature of Alzheimer's, with amyloid plaques representing sit...
Histone Lysine Demethylase KDM5 Inhibitor CPI-455 Induces Astrocytogenesis in Neural Stem Cells [0.03%]
组蛋白赖氨酸去甲基化酶KDM5抑制剂CPI-455诱导神经干细胞分化为星形胶质细胞
Thin Thin San,Junhyung Kim,Hyun-Jung Kim
Thin Thin San
Lysine-specific histone demethylase 5A (KDM5A) is known to facilitate proliferation in cancer cells and maintain stemness to repress the astrocytic differentiation of neural stem cells (NSCs). In the study presented here, we investigated th...
The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder [0.03%]
强迫症患者静息态脑电动力学和唾液微量元素的相关性研究
Galina Portnova,Guzal M Khayrullina,Ivan V Mikheev et al.
Galina Portnova et al.
The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. ...
Liubov S Kalinichenko,Johannes Kornhuber,Steffen Sinning et al.
Liubov S Kalinichenko et al.
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the ...
Investigating a Novel Neurodegenerative Disease Toxic Mechanism Involving Lipid Binding Specificity of Amyloid Oligomers [0.03%]
探究一种新的神经退行性疾病毒性机制，涉及淀粉样寡聚物的脂质结合特异性
Sarah S Hirschbeck,Edward T Lindberg,Joshua H Jang et al.
Sarah S Hirschbeck et al.
Exploring the mechanisms underlying the toxicity of amyloid oligomers (AOs) presents a significant opportunity for discovering cures and developing treatments for neurodegenerative diseases. Recently, using a combination of ion mobility spe...
Research Report: A Link between Sertraline Treatment and Susceptibility to (Mis)information [0.03%]
研究报告：左洛复治疗与易受（错误）信息影响之间的关联
Michal Piksa,Karolina Noworyta,Jan Piasecki et al.
Michal Piksa et al.
Recent research revealed that several psycho-cognitive processes, such as insensitivity to positive and negative feedback, cognitive rigidity, pessimistic judgment bias, and anxiety, are involved in susceptibility to fake news. All of these...