Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex [0.03%]
CHD8单倍体不足损害鼠前额叶皮质突触发育的性别二态性
Robert A Ellingford,Mizuki Tojo,M Albert Basson et al.
Robert A Ellingford et al.
CHD8 is a high penetrance, high confidence risk gene for autism spectrum disorder (ASD), a neurodevelopmental disorder that is substantially more prevalent among males than among females. Recent studies have demonstrated variable sex differ...
Amylin in Alcohol Addiction: A Potential New Treatment Target or an Adjuvant to Other Treatments? [0.03%]
胰岛素样肽YY和胰高血糖素样肽1在酒精依赖治疗中的作用：潜力新靶点还是辅助疗法？
Selim Boukabara,Mehdi Farokhnia,Lorenzo Leggio
Selim Boukabara
Amylin is a neuroendocrine hormone with a potential role in addictive disorders, including alcohol use disorder (AUD). In addition to reducing appetitive behavior, amylin has been shown to affect alcohol-related behaviors in rodents. Deline...
Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of α-Synuclein Amyloid Seeds [0.03%]
表面活性剂改性超声空化技术可提高α-突触核蛋白淀粉样蛋白种子的检测灵敏度
Kichitaro Nakajima,Tomoki Ota,Hajime Toda et al.
Kichitaro Nakajima et al.
The rapid amplification and sensitive detection of α-synuclein (αSyn) seeds is an efficient approach for the early diagnosis of Parkinson's disease. Ultrasonication stands out as a promising method for the rapid amplification of αSyn see...
Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis [0.03%]
非人灵长类缺血性卒中的综合评估：影像学、行为和血清蛋白质组分析
Ge Li,Lan Lan,Tingting He et al.
Ge Li et al.
Ischemic strokes, prevalence and impactful, underscore the necessity of advanced research models closely resembling human physiology. Our study utilizes nonhuman primates (NHPs) to provide a detailed exploration of ischemic stroke, integrat...
Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model [0.03%]
利用凋亡小体抑制纳米低聚物靶向缓解神经炎症可治疗实验性自身免疫性脑脊髓炎
Sadhana Sharma,Sydney Risen,Vincenzo S Gilberto et al.
Sadhana Sharma et al.
Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages of life. This disease affects the spinal co...
Celine Moser,Nadja Guschtschin-Schmidt,Mara Silber et al.
Celine Moser et al.
Alzheimer's disease is the most common form of dementia encountered in an aging population. Characteristic amyloid deposits of Aβ peptides in the brain are generated through cleavage of amyloid precursor protein (APP) by γ-secretase, an i...
Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer's Disease [0.03%]
基于香草酸模板设计和合成新型多功能配体抑制NLRP3炎性小体治疗阿尔茨海默病的研究
Gourav Singh,Gauri Shankar,Samir Ranjan Panda et al.
Gourav Singh et al.
Alzheimer's disease (AD) is the most common cause of dementia, which arises due to low levels of acetyl and butyrylcholines, an increase in oxidative stress, inflammation, metal dyshomeostasis, Aβ and tau aggregations. The currently availa...
Thiophene-Based Ligands for Specific Assignment of Distinct Aβ Pathologies in Alzheimer's Disease [0.03%]
基于噻吩的配体用于阿尔茨海默病中不同的Aβ病理的特异性分配
Therése Klingstedt,Linda Lantz,Hamid Shirani et al.
Therése Klingstedt et al.
Aggregated species of amyloid-β (Aβ) are one of the pathological hallmarks in Alzheimer's disease (AD), and ligands that selectively target different Aβ deposits are of great interest. In this study, fluorescent thiophene-based ligands h...
Selective Potentiation of the (α4)3(β2)2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues [0.03%]
NS9283类似物对(α4)3(β2)2型乙酰胆碱受体反应的选择性增效作用
Rebecca Appiani,Franco Viscarra,Philip C Biggin et al.
Rebecca Appiani et al.
NS9283, 3-(3-pyridyl)-5-(3-cyanophenyl)-1,2,4-oxadiazole, is a selective positive allosteric modulator of (α4)3(β2)2 nicotinic acetylcholine receptors (nAChRs). It has good subtype selective therapeutic potential afforded by its specific ...
Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders [0.03%]
通过药物下调炎症通路以靶向神经炎症对蛋白质错误折叠疾病具有神经营养作用
Sydney J Risen,Sean W Boland,Sadhana Sharma et al.
Sydney J Risen et al.
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category of progressive diseases includes, but is not limited to, Alzheimer's disease, Parkinson's disease, and prion diseases...